Spatial and functional heterogeneity of follicular helper T cells in autoimmunity.

Abstract:

:Follicular helper T cells provide signals that promote B cell development, proliferation, and production of affinity matured and appropriately isotype switched antibodies. In addition to their classical locations within B cell follicles and germinal centers therein, B cell helper T cells are also found in extrafollicular spaces - either in secondary lymphoid or non-lymphoid tissues. Both follicular and extrafollicular T helper cells drive autoantibody-mediated autoimmunity. Interfering with B cell help provided by T cells can ameliorate autoimmune disease in animal models and human patients. The next frontier in Tfh cell biology will be identification of Tfh cell-specific pathogenic changes in autoimmunity and exploiting them for therapeutic purposes.

journal_name

Curr Opin Immunol

authors

Seth A,Craft J

doi

10.1016/j.coi.2019.06.005

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1-9

eissn

0952-7915

issn

1879-0372

pii

S0952-7915(19)30015-9

journal_volume

61

pub_type

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