Abstract:
:The identification and quantitation of peptides selected by class II MHC molecules during natural processing of proteins is of key importance in understanding the repertoire and distribution of T cells. The examination of peptides selected by class II MHC molecules has depended greatly on mass spectrometry, a powerful technique that identifies and sequences peptides in complex mixtures with great sensitivity and precision. Such analysis has resulted in the identification of several factors, including the repertoire of peptides selected by MHC molecules during natural processing of proteins, motifs important for selection of processed peptides, conformational isomers of peptide-MHC complexes, and post-translational changes to the peptides.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Suri A,Lovitch SB,Unanue ERdoi
10.1016/j.coi.2005.11.002subject
Has Abstractpub_date
2006-02-01 00:00:00pages
70-7issue
1eissn
0952-7915issn
1879-0372pii
S0952-7915(05)00195-0journal_volume
18pub_type
杂志文章,评审abstract::Chronic non-communicable diseases (NCDs) are increasingly recognized as the major cause of morbidity and mortality worldwide. Effective, affordable and broadly accessible medicines for their treatment are much sought after. Therapeutic B-cell vaccines aim at inducing neutralizing auto-reactive antibodies against impor...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2010.02.009
更新日期:2010-06-01 00:00:00
abstract::Recent findings have significantly advanced our understanding of the mechanism by which the potent immunosuppressive drug rapamycin inhibits cytokine-dependent lymphocyte proliferation. The protein targeted by the immunophilin-rapamycin complex is a member of a newly defined family of phosphoinositide-3-kinase-related...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(98)80172-6
更新日期:1998-06-01 00:00:00
abstract::Defensins are a component of the host response against bacterial infections. Multiple studies suggest a linked upregulation of beta-defensins and pro-inflammatory cytokines expression in various tissues, as well as the possibility of mutual induction. Recent data demonstrate the importance of nucleotide-binding oligom...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2007.06.008
更新日期:2007-08-01 00:00:00
abstract::The steep rise in the incidence and prevalence of food allergy (FA) in the last few decades have focused attention of environmental mechanisms which act to promote disease, chief among which is the microbiome. Recent studies have now established the presence of pathogenic dysbiosis in FA that could be precipitated by ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2019.06.001
更新日期:2019-10-01 00:00:00
abstract::The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first minutes or hours of exposure to an infectious challenge. The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2005.11.014
更新日期:2006-02-01 00:00:00
abstract::Innate lymphoid cells (ILCs) constitute a heterogeneous population of cytokine-secreting cells that colonize different tissues and are heavily reliant on cytokines and other secreted factors for their development, maintenance and effector functions. Most ILCs are tissue resident and differentiate in non-lymphoid perip...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2018.11.004
更新日期:2019-02-01 00:00:00
abstract::A major problem in the analysis of vaccine candidates is the lack of any agreed upon surrogates of efficacy, which means that for diseases that depend on a strong T cell response (HIV, TB especially) the only option is to perform an efficacy trial, involving thousands of subjects, enormous costs, and years before the ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2020.05.002
更新日期:2020-08-01 00:00:00
abstract::Herpes zoster is common in older and immune suppressed persons due to diminished VZV-specific cellular immunity. A recombinant herpes zoster vaccine (RZV) consisting of a single VZV glycoprotein and an adjuvant system stimulates robust and persistent VZV-specific antibody and CD4+ T cell responses in these high-risk p...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2019.02.009
更新日期:2019-08-01 00:00:00
abstract::Systems biology strives to derive accurate predictive descriptions of complex systems such as innate immunity. The innate immune system is essential for host defense, yet the resulting inflammatory response must be tightly regulated. Current understanding indicates that this system is controlled by complex regulatory ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2004.11.005
更新日期:2005-02-01 00:00:00
abstract::T cells are spared from programmed cell death in the thymus after an appropriate interaction between the T-cell receptor and a self peptide/MHC complex; this step is referred to as positive selection. Recent work has focused on precise identification of the positively selecting ligand, and the cell that presents it. F...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(94)90101-5
更新日期:1994-04-01 00:00:00
abstract::Vascular endothelial cells participate in the process of allograft rejection by promoting both the recruitment and the activation of alloreactive T cells. There have been three major recent advances in the field of interactions between T cells and endothelial cells that are of direct relevance to the process of cell-m...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(98)80218-5
更新日期:1998-10-01 00:00:00
abstract::The treatment of autoimmune diseases using conventional chemical immunosuppressants has short-term effects, imposing the need for chronic treatment with its risks of over-immunosuppression. CD3-specific monoclonal antibodies can restore self-tolerance in a durable fashion after a single short-term treatment, as demons...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2005.09.011
更新日期:2005-12-01 00:00:00
abstract::Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place sp...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2020.08.003
更新日期:2020-10-07 00:00:00
abstract::The syndrome termed 'Drug Reaction with Eosinophilia and Systemic Symptoms' (DRESS) is an unpredictable, life-threatening condition associated with adverse reactions to therapy. Although the etiology of DRESS is poorly understood, genetic susceptibility markers have been identified within the HLA complex and there are...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2012.07.010
更新日期:2012-12-01 00:00:00
abstract::Monoclonal antibodies specific for defined peptide-MHC complexes are now being used to physically detect T-cell receptor ligands. These reagents have resulted in the identification of the cells that present antigen in lymphoid and non-lymphoid tissues after various forms of antigen administration. In addition, recent ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2003.11.001
更新日期:2004-02-01 00:00:00
abstract::Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein to orchestrate the innate host response to pathogen, ultimately leading to the induction of antiviral and inflammatory responses mediated by t...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2011.08.001
更新日期:2011-10-01 00:00:00
abstract::The development of genetic epidemiology methods using recent human genetic mapping information, together with the growing availability of candidate genes, has led to major advances in the identification of host genes involved in human infectious diseases. Within the past year, highlights include the mapping of a locus...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(97)80103-3
更新日期:1997-08-01 00:00:00
abstract::A little more than a decade after the explosion of research into recombinant live-attenuated or replication-deficient viruses as vaccine platforms, many viral vector-based vaccines have been licensed for animals. Progress has been slower for humans but 2011 will see the licensure of the first viral-vectored vaccine fo...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2011.03.006
更新日期:2011-06-01 00:00:00
abstract::During the past couple of years there has been significant progress in our understanding of the development of different lineages of T cells within the thymus. Pathways, subpopulations and cellular dynamics are all becoming clearer. Signal transduction through primary and accessory receptors is also beginning to be un...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(91)90051-2
更新日期:1991-04-01 00:00:00
abstract::Recent advances in the field of cellular therapy have focused on autologous T cells engineered to express a chimeric antigen receptor (CAR) against tumor antigens. Remarkable responses have been observed in patients receiving autologous CD19-redirected T cells for the treatment of B-lymphoid malignancies. However, the...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2018.03.013
更新日期:2018-04-01 00:00:00
abstract::V(D)J recombination can be separated into two basic operations: DNA cleavage and joining of broken ends. Our understanding of both reactions has increased substantially in the past year. Major advances include the development of a cell-free system capable of cleavage and the identification of several proteins involved...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(96)80055-0
更新日期:1996-04-01 00:00:00
abstract::Tolerance to the foetal 'allograft' has been extensively studied in the past few years, providing interesting new insights. In addition to a potential role for HLA-G, which has been widely discussed, there are hypotheses suggesting roles for several other molecules or cells: leukemia inhibitory factor and its receptor...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(00)00170-9
更新日期:2000-12-01 00:00:00
abstract::The strong genetic association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spondylitis (AS), which is restricted to HLA-B27 positive cases, has profound pathogenetic implications. ERAP1 is involved in trimming peptides to optimal length for binding to HLA class 1 molecules, thereby not only affec...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2012.11.002
更新日期:2013-02-01 00:00:00
abstract::Innate immune perception is the first line of inducible defense against invading pathogens. Plants lack specialized circulating immune cells. Therefore, diverse cell types are able to recognize and respond to pathogens. Surface-localized and intracellular plant innate immune receptors are capable of recognizing divers...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2019.12.007
更新日期:2020-02-01 00:00:00
abstract::Graft versus host disease (GVHD) remains the major obstacle to the application of bone marrow transplantation across HLA barriers. Recent advances in our understanding of GVHD pathophysiology have resulted in the evaluation in animal models and in clinical trials of some novel approaches to avoiding and treating GVHD....
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(93)90136-g
更新日期:1993-10-01 00:00:00
abstract::Antigens from a wide variety of pathogens have been identified as members of conserved heat-shock protein families, sharing upwards of 50% amino acid identity with corresponding host-cell proteins. Analysis of the responses to these conserved antigens may provide insights into regulation of the immune system during in...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(06)80029-4
更新日期:1992-08-01 00:00:00
abstract::The past year has seen the publication of significant new findings on the regulation of CD23 expression, the precise interaction of CD23 with CD21 and its functional consequences. Moreover, new advances have been made in unravelling the biochemical network of events downstream from the triggering of CD23 in human B ce...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/0952-7915(95)80110-3
更新日期:1995-06-01 00:00:00
abstract::A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particu...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2011.05.008
更新日期:2011-08-01 00:00:00
abstract::Dendritic cells (DC) are heterogenous, comprising several subpopulations of migratory and lymphoid-organ-resident types. Recent studies addressing the role of each subset in antigen presentation in vivo have revealed a complex division of labor within the DC network. In addition to CD8(+) DC, migratory lung or dermal ...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.coi.2009.03.011
更新日期:2009-02-01 00:00:00
abstract::Tumors of diverse origin have recently been shown to express CD95 ligand and to induce apoptosis in CD95-expressing targets in vitro; however, in vivo, enhanced tumor growth and rejection have both been observed as a consequence of either immunosuppressive or proinflammatory functions of CD95 ligand. The final in vivo...
journal_title:Current opinion in immunology
pub_type: 杂志文章,评审
doi:10.1016/s0952-7915(98)80225-2
更新日期:1998-10-01 00:00:00