Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice.

abstract：:The polymerase chain reaction allows the characterization of RNA and DNA sequences in samples as small as a single cell. The recent development of amplification systems designed to isolate rearranged immunoglobulin genes from single B lineage cells has provided a powerful tool to investigate various aspects of B-cell ...

journal_title：Current opinion in immunology

authors： Ehlich A,Küppers R

更新日期：1995-04-01 00:00:00

abstract：:Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-kappa B (nuclear factor kappa B) activation is accomplished by recruitin...

journal_title：Current opinion in immunology

authors： Dobbelaere DA,Küenzi P

更新日期：2004-08-01 00:00:00

abstract：:Cytokines have been presumed to play an important role during T-cell development, but until recently formal proof has been missing. Most cytokine-knockout mice show apparently normal intrathymic T-cell development. The exception to this is IL-7, as both IL-7 and IL-7R alpha knockout mice show abnormally low thymic cel...

journal_title：Current opinion in immunology

authors： Zlotnik A,Moore TA

更新日期：1995-04-01 00:00:00

abstract：:Recent developments in the field of immune memory research and the accumulating literature on age-related alterations in homeostasis, primary and memory T cell responses make it pertinent to address whether and how memory responses are affected by aging with regard to their generation, maintenance, and protective func...

journal_title：Current opinion in immunology

authors： Nikolich-Zugich J,Rudd BD

更新日期：2010-08-01 00:00:00

abstract：:Zika virus (ZIKV) is the most recent mosquito-transmitted virus to cause a global health crisis following its entrance into a naïve population in the Western Hemisphere. Once the ZIKV outbreak began investigators rapidly established small and large animal models of pathogenesis, developed a number candidate vaccines u...

journal_title：Current opinion in immunology

authors： Richner JM,Diamond MS

更新日期：2018-08-01 00:00:00

abstract：:V(D)J recombination not only comprises the molecular mechanism that insures diversity of the immune system but also constitutes a critical checkpoint in the developmental program of B and T lymphocytes. The analysis of human patients with severe combined immune deficiency (SCID) has enabled (and will enable in the fut...

journal_title：Current opinion in immunology

authors： de Villartay JP,Poinsignon C,de Chasseval R,Buck D,Le Guyader G,Villey I

更新日期：2003-10-01 00:00:00

abstract：:Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein to orchestrate the innate host response to pathogen, ultimately leading to the induction of antiviral and inflammatory responses mediated by t...

journal_title：Current opinion in immunology

authors： Belgnaoui SM,Paz S,Hiscott J

更新日期：2011-10-01 00:00:00

abstract：:Intimate interactions between multipotential hemopoietic stem cells and their microenvironment work towards redefining the identity and the differentiative fate of these primitive cells. Molecular cues delivered by the microenvironment frequently act in an instructive fashion by initiating intracellular signaling path...

journal_title：Current opinion in immunology

authors： Georgopoulos K

更新日期：1997-04-01 00:00:00

abstract：:Immune system function declines with age. Here we review and compare age-associated changes in murine and human B cell pools and humoral immune responses. We summarize changes in B cell generation and homeostasis, as well as notable changes at the subcellular level; then discuss how these changes help to explain alter...

journal_title：Current opinion in immunology

authors： Scholz JL,Diaz A,Riley RL,Cancro MP,Frasca D

更新日期：2013-08-01 00:00:00

abstract：:NKT cells utilize a restricted alphabeta TCR repertoire that recognizes glycolipids in association with CD1d. The recent development of fluorescent CD1d tetramers loaded with the synthetic glycolipid alpha-galactosyl-ceramide has led to a clearer definition of NKT-cell subsets as well as important insights into their ...

journal_title：Current opinion in immunology

authors： MacDonald HR

更新日期：2002-04-01 00:00:00

abstract：:The development of genetic epidemiology methods using recent human genetic mapping information, together with the growing availability of candidate genes, has led to major advances in the identification of host genes involved in human infectious diseases. Within the past year, highlights include the mapping of a locus...

journal_title：Current opinion in immunology

authors： Abel L,Dessein AJ

更新日期：1997-08-01 00:00:00

abstract：:Over two decades of research have increased the interest in factors from the tumor necrosis factor family. The vast majority of these factors are powerful modulators of critical immune functions and participate in pathogenic mechanisms leading to autoimmune disease. This field constantly evolves with the addition of n...

journal_title：Current opinion in immunology

authors： Mackay F,Kalled SL

更新日期：2002-12-01 00:00:00

abstract：:Analysis of T-cell development in transgenic and gene-deficient mice suggests that the co-receptor function of CD8 is essential for positive selection. Recent data also demonstrate that the requirement for CD4 and CD8 in negative selection of T cells is not absolute and may be regulated by T-cell receptor affinity for...

journal_title：Current opinion in immunology

authors： Wallace VA,Penninger J,Mak TW

更新日期：1993-04-01 00:00:00

abstract：:Immunotherapy of cancer with blockade of inhibitory immune checkpoints and adoptive cell therapies have led to impressive clinical responses in several cancers. However, with increasing utilization of these therapies, immune-related adverse events have emerged as a major obstacle. Herein I discuss recent insights into...

journal_title：Current opinion in immunology

authors： Dhodapkar KM

更新日期：2019-12-01 00:00:00

abstract：:Flaviviruses are a group of important emerging and re-emerging human pathogens that cause worldwide epidemics with thousands of deaths annually. Flaviviruses are small, enveloped, positive-sense, single-stranded RNA viruses that are obligate intracellular pathogens, relying heavily on host cell machinery for productiv...

journal_title：Current opinion in immunology

authors： Li M,Ramage H,Cherry S

更新日期：2020-10-01 00:00:00

abstract：:Diseases due to defect in tolerance induction such as allergy, celiac disease, or Type 1 Diabetes develop mostly in childhood indicating the necessity of early intervention for primary prevention. Epidemiological studies report that breastfeeding could protect from these diseases. However, data are controversial and t...

journal_title：Current opinion in immunology

authors： Verhasselt V

更新日期：2010-10-01 00:00:00

abstract：:The diverse αβ T cell receptor (TCR) repertoire exhibits versatility in its ability to generate antigen (Ag) receptors capable of interacting with polymorphic Major Histocompatibility Complex (MHC) molecules and monomorphic MHC-I like molecules, including the CD1 and MR1 families. Collectively, these evolutionarily re...

journal_title：Current opinion in immunology

authors： Eckle SB,Turner SJ,Rossjohn J,McCluskey J

更新日期：2013-10-01 00:00:00

abstract：:Accessory molecules are required for microbial recognition by Toll-like receptor (TLR), subsequent signaling, and regulation of ensuing immune responses. Accessory molecules regulate TLRs on the cell surface (MD-2 and RP105), or in the endoplasmic reticulum (ER) (Unc93B, PRAT4A, and gp96). Other types of accessory mol...

journal_title：Current opinion in immunology

authors： Akashi-Takamura S,Miyake K

更新日期：2008-08-01 00:00:00

abstract：:The transplantation of organs between individuals of disparate species is being considered as a potential solution to a serious shortage of donor organs for clinical transplantation. We summarize recent papers concerning the immunologic barrier to xenotransplantation, the pathogenesis of hyperacute rejection and repor...

journal_title：Current opinion in immunology

authors： Platt JL,Bach FH

更新日期：1991-10-01 00:00:00

abstract：:Many recent studies suggest an involvement of gamma delta T cells in the immune response to infectious pathogens including viruses, bacteria and eukaryotic parasites. However, it remains unclear whether the responses of gamma delta T cells are specifically directed against antigens derived from these pathogens or agai...

journal_title：Current opinion in immunology

authors： Born WK,Harshan K,Modlin RL,O'Brien RL

更新日期：1991-08-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) persists within the host in the presence of concomitant immunity by establishing a latent infection within sensory neurons. HSV-1 latency is widely viewed as a neuron-enforced quiescent state of the virus, in which a lack of viral protein synthesis prevents recognition of the infect...

journal_title：Current opinion in immunology

authors： Khanna KM,Lepisto AJ,Decman V,Hendricks RL

更新日期：2004-08-01 00:00:00

abstract：:Mucosal vaccines may be used both to prevent mucosal infections through the activation of antimicrobial immunity and to treat systemic inflammatory diseases through the induction of antigen-specific mucosal tolerance. New, efficient mucosal adjuvants for human use have been designed based on, amongst others, bacterial...

journal_title：Current opinion in immunology

authors： Eriksson K,Holmgren J

更新日期：2002-10-01 00:00:00

abstract：:The syndrome termed 'Drug Reaction with Eosinophilia and Systemic Symptoms' (DRESS) is an unpredictable, life-threatening condition associated with adverse reactions to therapy. Although the etiology of DRESS is poorly understood, genetic susceptibility markers have been identified within the HLA complex and there are...

journal_title：Current opinion in immunology

authors： Camous X,Calbo S,Picard D,Musette P

更新日期：2012-12-01 00:00:00

abstract：:T cell exhaustion represents a continuous spectrum of cellular dysfunction induced during chronic viral infection, facilitating viral persistence and associating with poor clinical outcome. Modulation of T cell exhaustion can restore function in exhausted CD8 T cells, promoting viral clearance. Exhaustion has also bee...

journal_title：Current opinion in immunology

authors： McKinney EF,Smith KG

更新日期：2016-12-01 00:00:00

abstract：:Recent findings have significantly advanced our understanding of the mechanism by which the potent immunosuppressive drug rapamycin inhibits cytokine-dependent lymphocyte proliferation. The protein targeted by the immunophilin-rapamycin complex is a member of a newly defined family of phosphoinositide-3-kinase-related...

journal_title：Current opinion in immunology

authors： Abraham RT

更新日期：1998-06-01 00:00:00

abstract：:T cell responses are regulated by integrating positive and negative signals from costimulatory and inhibitory receptors. While the function of specific T cell costimulatory molecules during infections has been appreciated for some time, recent observations have now revealed a crucial role for inhibitory receptors in r...

journal_title：Current opinion in immunology

authors： Crawford A,Wherry EJ

更新日期：2009-04-01 00:00:00

abstract：:Until very recently, the function of CD14 was thought to be limited to innate immune responses to bacterial and other microbial structures. It is now known that macrophage CD14 serves an additional unexpected function, namely as a receptor involved in the recognition and phagocytosis of cells undergoing apoptosis. In ...

journal_title：Current opinion in immunology

authors： Gregory CD

更新日期：2000-02-01 00:00:00

abstract：:Dendritic cells (DC) are heterogenous, comprising several subpopulations of migratory and lymphoid-organ-resident types. Recent studies addressing the role of each subset in antigen presentation in vivo have revealed a complex division of labor within the DC network. In addition to CD8(+) DC, migratory lung or dermal ...

journal_title：Current opinion in immunology

authors： Segura E,Villadangos JA

更新日期：2009-02-01 00:00:00

abstract：:The recent discovery of PTPN22 as a novel susceptibility gene in human type 1 diabetes and continued progress in defining genes in animal models of the disease mark a fruitful period in the field of type 1 diabetes genetics. In addition, the similarities of the genetic and functional aspects across species have been s...

journal_title：Current opinion in immunology

authors： Maier LM,Wicker LS

更新日期：2005-12-01 00:00:00

abstract：:V(D)J recombination in B and T cells is required for the generation of receptors with a broad spectrum of specificity to foreign antigen. A total number of three immunoglobulin (Ig) and four T cell receptor (Tcr) loci can be targeted by the recombinase enzyme (RAG1/2) in a defined series of recombination events, which...

journal_title：Current opinion in immunology

authors： Chaumeil J,Skok JA

更新日期：2012-04-01 00:00:00