Abstract:
:Three known lineages of antigen-presenting molecules restrict T-cell responses to microbial antigens: MHC class I and MHC encoded class I like molecules present peptides derived from the proteolysis of intracellular pathogens, MHC class ii molecules present peptides derived from the proteolysis of extracellular pathogens and CD1 molecules present unique microbial lipids and glycolipids. Recent studies have indicated that CD1 molecules mediate a novel system of antigen presentation and that MHC-encoded class I-like molecules can present unique subsets of intracellularly derived peptides.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Melián A,Beckman EM,Porcelli SA,Brenner MBdoi
10.1016/s0952-7915(96)80109-9subject
Has Abstractpub_date
1996-02-01 00:00:00pages
82-8issue
1eissn
0952-7915issn
1879-0372pii
S0952-7915(96)80109-9journal_volume
8pub_type
杂志文章,评审abstract::CD8 T cell differentiation is a tightly regulated process generating effector and memory T cells over the course of acute infections. In cancer and chronic infection, this differentiation program is derailed, and antigen-specific CD8 T cells differentiate to a hyporesponsive state generally referred to as T cell exhau...
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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abstract::Graft versus host disease (GVHD) remains the major obstacle to the application of bone marrow transplantation across HLA barriers. Recent advances in our understanding of GVHD pathophysiology have resulted in the evaluation in animal models and in clinical trials of some novel approaches to avoiding and treating GVHD....
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journal_title:Current opinion in immunology
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