Abstract：
:Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-kappa B (nuclear factor kappa B) activation is accomplished by recruiting the IKK (I kappa B kinase) complex, a central regulator of NF-kappa B pathways, to the surface of the transforming schizont, where it becomes permanently activated. Constitutive activation of the PI-3K-PKB [phosphoinositide 3-kinase-(Akt) protein kinase B] pathway is likely to be indirect and is essential for continuous proliferation. Theileria-transformed T cells express a range of anti-apoptotic proteins that can be expected to provide protection against apoptosis induced by death receptors, as well as cellular control mechanisms that are mobilised to eliminate cells that entered a cycle of uncontrolled proliferation.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Dobbelaere DA,Küenzi Pdoi
10.1016/j.coi.2004.05.009subject
Has Abstractpub_date
2004-08-01 00:00:00pages
524-30issue
4eissn
0952-7915issn
1879-0372pii
S0952791504000780journal_volume
16pub_type
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