Novel targeted therapies for autoimmunity.

abstract：:Intimate interactions between multipotential hemopoietic stem cells and their microenvironment work towards redefining the identity and the differentiative fate of these primitive cells. Molecular cues delivered by the microenvironment frequently act in an instructive fashion by initiating intracellular signaling path...

journal_title：Current opinion in immunology

authors： Georgopoulos K

更新日期：1997-04-01 00:00:00

abstract：:The IL-17/IL-17 receptor family is the newest and least understood of the cytokine subclasses. Composed of ligands IL-17A-IL-17F and receptors IL-17RA-IL-17RE, these cytokines have many unique structural and functional features. Since the discovery of the 'Th17' subset in 2005, particular attention has been paid to IL...

journal_title：Current opinion in immunology

authors： Gaffen SL

更新日期：2011-10-01 00:00:00

abstract：:Significant insight has been gained into constraints on the sensitivity and specificity of staining with class I tetramers. The function of the populations that are defined varies with the clinical situation. Insight has also been gained into the determinants of the CD8(+) T cell response during primary and chronic HI...

journal_title：Current opinion in immunology

authors： Kelleher AD,Rowland-Jones SL

更新日期：2000-08-01 00:00:00

abstract：:Atopic dermatitis is a chronic inflammatory skin disease associated with elevated serum IgE levels and sensitization to a variety of inhalant, food and microbial allergens. Controlled challenges have provided substantial evidence that allergens can trigger acute IgE-mediated mast-cell dependent exacerbations of eczema...

journal_title：Current opinion in immunology

authors： Leung DY

更新日期：1993-12-01 00:00:00

abstract：:Herpes zoster is common in older and immune suppressed persons due to diminished VZV-specific cellular immunity. A recombinant herpes zoster vaccine (RZV) consisting of a single VZV glycoprotein and an adjuvant system stimulates robust and persistent VZV-specific antibody and CD4+ T cell responses in these high-risk p...

journal_title：Current opinion in immunology

authors： Heineman TC,Cunningham A,Levin M

更新日期：2019-08-01 00:00:00

abstract：:Zika virus (ZIKV) is the most recent mosquito-transmitted virus to cause a global health crisis following its entrance into a naïve population in the Western Hemisphere. Once the ZIKV outbreak began investigators rapidly established small and large animal models of pathogenesis, developed a number candidate vaccines u...

journal_title：Current opinion in immunology

authors： Richner JM,Diamond MS

更新日期：2018-08-01 00:00:00

abstract：:Graft versus host disease (GVHD) remains the major obstacle to the application of bone marrow transplantation across HLA barriers. Recent advances in our understanding of GVHD pathophysiology have resulted in the evaluation in animal models and in clinical trials of some novel approaches to avoiding and treating GVHD....

journal_title：Current opinion in immunology

authors： Sykes M

更新日期：1993-10-01 00:00:00

abstract：:The hallmark of the innate immune response of higher insects is the rapid and transient synthesis of a battery of broad spectrum antimicrobial peptides by the fat body. The control of the genes encoding these peptides involves cis-regulatory promoter elements homologous to sequences functional in mammalian acute-phase...

journal_title：Current opinion in immunology

authors： Hoffmann JA,Reichhart JM,Hetru C

更新日期：1996-02-01 00:00:00

abstract：:The polymerase chain reaction allows the characterization of RNA and DNA sequences in samples as small as a single cell. The recent development of amplification systems designed to isolate rearranged immunoglobulin genes from single B lineage cells has provided a powerful tool to investigate various aspects of B-cell ...

journal_title：Current opinion in immunology

authors： Ehlich A,Küppers R

更新日期：1995-04-01 00:00:00

abstract：:Follicular helper T cells provide signals that promote B cell development, proliferation, and production of affinity matured and appropriately isotype switched antibodies. In addition to their classical locations within B cell follicles and germinal centers therein, B cell helper T cells are also found in extrafollicu...

journal_title：Current opinion in immunology

authors： Seth A,Craft J

更新日期：2019-12-01 00:00:00

abstract：:T cell exhaustion represents a continuous spectrum of cellular dysfunction induced during chronic viral infection, facilitating viral persistence and associating with poor clinical outcome. Modulation of T cell exhaustion can restore function in exhausted CD8 T cells, promoting viral clearance. Exhaustion has also bee...

journal_title：Current opinion in immunology

authors： McKinney EF,Smith KG

更新日期：2016-12-01 00:00:00

abstract：:Innate immunity, our inborn immediate defence mechanism, was thought for a long time to be non-specific and, consequently, research into innate mechanisms often took second place to research into adaptive immunity. In recent decades, however, the spotlight has shone on groundbreaking advances into mechanisms of innate...

journal_title：Current opinion in immunology

authors： Coutinho A,Poltorack A

更新日期：2003-12-01 00:00:00

abstract：:Distinctions between tumor necrosis factor, TNF-alpha, and lymphotoxin, TNF-beta, have previously been based on the differences between their protein sequences, biological activity, and molecular regulation. In the past year, elucidation of the molecular nature of the two molecules and the interactions with common rec...

journal_title：Current opinion in immunology

authors： Ruddle NH

更新日期：1992-06-01 00:00:00

abstract：:The discovery of novel immune receptors has led to a recent renaissance of research into the innate immune system, following decades of intense research of the adaptive immune system. Of particular interest has been the discovery of the natural killer (NK) cell receptors which, depending on type, interact with classic...

journal_title：Current opinion in immunology

authors： Sambrook JG,Beck S

更新日期：2007-10-01 00:00:00

abstract：:Current models suggest that continuous antigenic stimulation of memory B cells is required to maintain long-term antibody production. In view of recent developments concerning plasma cell longevity, a new model is described that incorporates the important role of long-lived plasma cells in sustaining persistent antibo...

journal_title：Current opinion in immunology

authors： Slifka MK,Ahmed R

更新日期：1998-06-01 00:00:00

abstract：:Dendritic cells (DCs) with their potent antigen presenting ability are long considered as critical factor in antitumor immunity. Despite high potential in promoting antitumor responses, tumor-associated DCs are largely defective in their functional activity and can contribute to immune suppression in cancer. In recent...

journal_title：Current opinion in immunology

authors： Veglia F,Gabrilovich DI

更新日期：2017-04-01 00:00:00

abstract：:The discovery of defined tumor antigens and their application in therapeutic cancer vaccines has not yet resulted in a successful therapy for cancer patients. Recent data suggest that this might be because most current clinical immunotherapeutic strategies rely on a tolerized tumor-reactive T-cell repertoire, resultin...

journal_title：Current opinion in immunology

authors： Overwijk WW

更新日期：2005-04-01 00:00:00

abstract：:Antigen presenting cells (APCs) alert the immune system to attack by extracellular organisms; APCs achieve this via internalization, degradation, and display of antigenic fragments on the cell surface by MHC class II molecules. These class II molecules bind to an accessory protein, termed the invariant chain, that ens...

journal_title：Current opinion in immunology

authors： Hiltbold EM,Roche PA

更新日期：2002-02-01 00:00:00

abstract：:Accessory molecules are required for microbial recognition by Toll-like receptor (TLR), subsequent signaling, and regulation of ensuing immune responses. Accessory molecules regulate TLRs on the cell surface (MD-2 and RP105), or in the endoplasmic reticulum (ER) (Unc93B, PRAT4A, and gp96). Other types of accessory mol...

journal_title：Current opinion in immunology

authors： Akashi-Takamura S,Miyake K

更新日期：2008-08-01 00:00:00

abstract：:There is growing evidence that different antigen-presenting cells use specialized mechanisms for antigen uptake. Macropinocytosis and the activity of the mannose receptor have been identified as efficient mechanisms of antigen capture in dendritic cells. The mechanism of uptake determines the intracellular compartment...

journal_title：Current opinion in immunology

authors： Lanzavecchia A

更新日期：1996-06-01 00:00:00

abstract：:Immunotherapy of cancer through adoptive transfer of genetically engineered T-cells constitutes a more powerful strategy than attempts to mobilize the endogenous T-cell repertoire. Application of this technology in patients offers great opportunities towards a long-awaited breakthrough in cancer immunotherapy. However...

journal_title：Current opinion in immunology

authors： Offringa R

更新日期：2009-04-01 00:00:00

abstract：:Murine gamma-herpesvirus 68 (gammaHV68) infection is a new model for understanding how immunity and chronic gamma-herpesvirus infection inter-relate. gammaHV68 is closely related to the human Epstein-Barr virus and Kaposi's sarcoma herpesvirus and is associated with tumors, vasculitis of the great elastic arteries and...

journal_title：Current opinion in immunology

authors： Virgin HW,Speck SH

更新日期：1999-08-01 00:00:00

abstract：:T-lymphocyte activation is initiated by the interaction of the alpha beta TCR with a complex consisting of a class I or class II MHC-encoded molecule and an antigenic peptide, displayed on the surface of an antigen-presenting cell. Real-time binding measurements using surface plasmon resonance have revealed kinetic an...

journal_title：Current opinion in immunology

authors： Margulies DH,Plaksin D,Khilko SN,Jelonek MT

更新日期：1996-04-01 00:00:00

abstract：:Discovered during the past ten years, Janus kinases and signal transducers and activators of transcription have emerged as critical elements in cytokine signaling and immunoregulation. Recently, knockout mice for all the members of these families have been generated, with remarkably specific outcomes. Equally exciting...

journal_title：Current opinion in immunology

authors： Gadina M,Hilton D,Johnston JA,Morinobu A,Lighvani A,Zhou YJ,Visconti R,O'Shea JJ

更新日期：2001-06-01 00:00:00

abstract：:Animal models of inflammatory bowel disease (IBD) have been useful in the identification of those immune responses uniquely involved in IBD pathogenesis and in defining the important roles of environmental influences, such as normal luminal bacterial flora and the genetic composition of the host, in modifying IBD-asso...

journal_title：Current opinion in immunology

authors： Blumberg RS,Saubermann LJ,Strober W

更新日期：1999-12-01 00:00:00

abstract：:The basic premise of the epitope-based approach to vaccine development is that, in certain cases, the responses induced by the natural immunogen are not optimal, and can be improved upon by isolation or optimization of specific components of the response. For example, immunodominance is a key factor limiting the type ...

journal_title：Current opinion in immunology

authors： Sette A,Fikes J

更新日期：2003-08-01 00:00:00

abstract：:The usefulness of molecular diagnosis is now well established for genetically determined recurrent fevers. In familial Mediterranean fever, the severity of the disease and the risk of renal amyloidosis are correlated with mutations in MEFV, and the serum amyloid-associated protein (SAA)1 alpha/alpha allele is a modify...

journal_title：Current opinion in immunology

authors： Delpech M,Grateau G

更新日期：2001-10-01 00:00:00

abstract：:In higher vertebrates, recognition of the non-self signature of invading viruses by genome-encoded pattern recognition receptors initiates antiviral innate immunity. Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) detect viral RNA as a non-self pattern in the cytoplasm and activate downstream signaling. D...

journal_title：Current opinion in immunology

authors： Yoneyama M,Onomoto K,Jogi M,Akaboshi T,Fujita T

更新日期：2015-02-01 00:00:00

abstract：:Physiological cell death, which occurs as a continuous byproduct of cellular turnover, is non-immunogenic or even tolerogenic, thereby avoiding autoimmunity. By contrast, cancer cell death elicited by radiotherapy and some chemotherapeutic agents such as anthracyclines is immunogenic. Recent data suggest that innate a...

journal_title：Current opinion in immunology

authors： Tesniere A,Apetoh L,Ghiringhelli F,Joza N,Panaretakis T,Kepp O,Schlemmer F,Zitvogel L,Kroemer G

更新日期：2008-10-01 00:00:00

abstract：:Immunotherapy of cancer with blockade of inhibitory immune checkpoints and adoptive cell therapies have led to impressive clinical responses in several cancers. However, with increasing utilization of these therapies, immune-related adverse events have emerged as a major obstacle. Herein I discuss recent insights into...

journal_title：Current opinion in immunology

authors： Dhodapkar KM

更新日期：2019-12-01 00:00:00