Evolutionary vignettes of natural killer cell receptors.

Abstract:

:The discovery of novel immune receptors has led to a recent renaissance of research into the innate immune system, following decades of intense research of the adaptive immune system. Of particular interest has been the discovery of the natural killer (NK) cell receptors which, depending on type, interact with classical or non-classical MHC class I antigens of the adaptive immune system, thus functioning at the interface of innate and adaptive immunity. Here, we review recent progress with respect to two such families of NK receptors, the killer immunoglobulin-like receptors (KIRs) and the killer cell lectin-like receptors (KLRs), and attempt to trace their evolution across vertebrates.

journal_name

Curr Opin Immunol

authors

Sambrook JG,Beck S

doi

10.1016/j.coi.2007.08.002

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

553-60

issue

5

eissn

0952-7915

issn

1879-0372

pii

S0952-7915(07)00147-1

journal_volume

19

pub_type

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