Abstract：
:The canonical NF-κB pathway instructs the expression of inflammatory genes by the RelA:p50 transcription factor in response to diverse cell-activating stimuli. However, this mainstay RelA:p50 transcriptional output must also be curated so as to provide for stimulus-type-specific and cell-type-specific inflammatory responses adapted to the local tissue-microenvironment. Here, we summarize the fundamental mechanisms regulating RelA:p50-mediated gene expressions and discuss how the NF-κB system imparts specificity in the inflammatory gene program. We put forward a conceptual framework where the dynamical attributes and the composition of the nuclear NF-κB complexes cumulatively instruct context-specific inflammatory gene patterns. We propose that integrating mechanistic knowledge and systems-level analyses may offer further insights on NF-κB-mediated inflammatory gene control in the future.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Chawla M,Roy P,Basak Sdoi
10.1016/j.coi.2020.08.005subject
Has Abstractpub_date
2020-09-05 00:00:00pages
21-27eissn
0952-7915issn
1879-0372pii
S0952-7915(20)30081-9journal_volume
68pub_type
杂志文章,评审abstract：:In the last year progress has been made towards elucidating the roles of the MHC gene products in autoimmunity. A major advance has been the recent determination of the crystallographic structure of the human MHC class II molecule, which will be invaluable in delineating the minimum structural requirements for peptide...
journal_title：Current opinion in immunology
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abstract：:Natural killer T (NKT) cells are a distinct lymphocyte lineage that regulates immune responses. During their development in the thymus, immature uncommitted double-positive CD4+CD8+ thymocytes that rearrange the semi-invariant T-cell receptor found on mature NKT cells are positively selected by the non-classical MHC c...
journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2018.03.013
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2013.05.012
更新日期：2013-08-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2011.03.004
更新日期：2011-06-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(97)80103-3
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2008.07.001
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2007-04-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2004-10-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(00)00239-9
更新日期：2001-08-01 00:00:00
