T cell mediated immunosuppression.

abstract：:Recent research developments support the following views regarding antigen recognition in autoimmune demyelinating disease: there may be no single autoimmune target protein; diverse peptide self-determinants from multiple myelin proteins can be recognized; target determinant epitopes may differ among individuals; and ...

journal_title：Current opinion in immunology

authors： Tuohy VK,Fritz RB,Ben-Nun A

更新日期：1994-12-01 00:00:00

abstract：:Cancer results from a tumor cell intrinsic dysregulation of oncogenes, tumor suppressor and stability genes as well as from the avoidance of immunosurveillance. A complex network of cellular interactions allows one to mount cognate anti-tumor immune responses. Recently, discoveries have been made regarding the links b...

journal_title：Current opinion in immunology

authors： Ghiringhelli F,Apetoh L,Housseau F,Kroemer G,Zitvogel L

更新日期：2007-04-01 00:00:00

abstract：:The invariant chain (Ii) has been shown to play a critical role in the assembly, intracellular transport and function of MHC class II molecules. Recent studies suggest that these distinct activities can in many cases be attributed to distinct isoforms of Ii or to specific regions within it. Thus, regulation of Ii synt...

journal_title：Current opinion in immunology

authors： Sant AJ,Miller J

更新日期：1994-02-01 00:00:00

abstract：:A diverse B cell repertoire is essential for an effective immune response. Not only to provide a variety of antibodies to recognise the multiplicity of likely pathogen challenge, but also because B cells are important regulators of the immune response. In addition to their excellent capabilities as antigen presenting ...

journal_title：Current opinion in immunology

authors： Dunn-Walters DK,Ademokun AA

更新日期：2010-08-01 00:00:00

abstract：:Monoclonal antibodies specific for defined peptide-MHC complexes are now being used to physically detect T-cell receptor ligands. These reagents have resulted in the identification of the cells that present antigen in lymphoid and non-lymphoid tissues after various forms of antigen administration. In addition, recent ...

journal_title：Current opinion in immunology

authors： Germain RN,Jenkins MK

更新日期：2004-02-01 00:00:00

abstract：:The germinal centre (GC) is a specialized cellular structure that forms in response to antigenic stimulation. It generates long-term humoral immunity through the production of memory B cells and long-lived antibody-secreting plasma cells. Conventional GCs form within secondary lymphoid organs, where networks of specia...

journal_title：Current opinion in immunology

authors： Silva-Cayetano A,Linterman MA

更新日期：2020-04-20 00:00:00

abstract：:The usefulness of molecular diagnosis is now well established for genetically determined recurrent fevers. In familial Mediterranean fever, the severity of the disease and the risk of renal amyloidosis are correlated with mutations in MEFV, and the serum amyloid-associated protein (SAA)1 alpha/alpha allele is a modify...

journal_title：Current opinion in immunology

authors： Delpech M,Grateau G

更新日期：2001-10-01 00:00:00

abstract：:T cells are spared from programmed cell death in the thymus after an appropriate interaction between the T-cell receptor and a self peptide/MHC complex; this step is referred to as positive selection. Recent work has focused on precise identification of the positively selecting ligand, and the cell that presents it. F...

journal_title：Current opinion in immunology

authors： Hogquist KA,Jameson SC,Bevan MJ

更新日期：1994-04-01 00:00:00

abstract：:Epstein-Barr virus induces a potent cytotoxic T lymphocyte response in man that is preferentially directed towards a particular subset of the virus latent cycle antigens; the immunodominance of these proteins, apparent in both primary and memory responses, may reflect some differential access to the HLA class I proces...

journal_title：Current opinion in immunology

authors： Rickinson AB,Lee SP,Steven NM

更新日期：1996-08-01 00:00:00

abstract：:Rheumatoid arthritis is often considered to be an autoimmune disease in which the abnormal immunological response is triggered by an infectious agent(s) but progress towards identifying such extrinsic factors has so far been unrevealing. In contrast, the genetic component of host susceptibility is slowly becoming clea...

journal_title：Current opinion in immunology

authors： Wordsworth P

更新日期：1992-12-01 00:00:00

abstract：:Zika virus (ZIKV) is the most recent mosquito-transmitted virus to cause a global health crisis following its entrance into a naïve population in the Western Hemisphere. Once the ZIKV outbreak began investigators rapidly established small and large animal models of pathogenesis, developed a number candidate vaccines u...

journal_title：Current opinion in immunology

authors： Richner JM,Diamond MS

更新日期：2018-08-01 00:00:00

abstract：:The adhesive phenotypes expressed by Plasmodium-falciparum-infected erythrocytes were previously thought simply to permit sequestration of parasites in the peripheral circulation. Recent work has illuminated how falciparum-infected erythrocytes may modulate the function of monocytes, macrophages and myeloid dendritic ...

journal_title：Current opinion in immunology

authors： Urban BC,Roberts DJ

更新日期：2002-08-01 00:00:00

abstract：:Recent advances in the field of cellular therapy have focused on autologous T cells engineered to express a chimeric antigen receptor (CAR) against tumor antigens. Remarkable responses have been observed in patients receiving autologous CD19-redirected T cells for the treatment of B-lymphoid malignancies. However, the...

journal_title：Current opinion in immunology

authors： Daher M,Rezvani K

更新日期：2018-04-01 00:00:00

abstract：:CD8 T cell differentiation is a tightly regulated process generating effector and memory T cells over the course of acute infections. In cancer and chronic infection, this differentiation program is derailed, and antigen-specific CD8 T cells differentiate to a hyporesponsive state generally referred to as T cell exhau...

journal_title：Current opinion in immunology

authors： Philip M,Schietinger A

更新日期：2019-06-01 00:00:00

abstract：:The ensemble of antibodies found in serum and secretions represents the key adaptive component of B-cell mediated humoral immunity. The antibody repertoire is shaped by the historical record of exposure to exogenous factors such as pathogens and vaccines, as well as by endogenous host-intrinsic factors such as genetic...

journal_title：Current opinion in immunology

authors： Wine Y,Horton AP,Ippolito GC,Georgiou G

更新日期：2015-08-01 00:00:00

abstract：:Until very recently, the function of CD14 was thought to be limited to innate immune responses to bacterial and other microbial structures. It is now known that macrophage CD14 serves an additional unexpected function, namely as a receptor involved in the recognition and phagocytosis of cells undergoing apoptosis. In ...

journal_title：Current opinion in immunology

authors： Gregory CD

更新日期：2000-02-01 00:00:00

abstract：:T cell responses are regulated by integrating positive and negative signals from costimulatory and inhibitory receptors. While the function of specific T cell costimulatory molecules during infections has been appreciated for some time, recent observations have now revealed a crucial role for inhibitory receptors in r...

journal_title：Current opinion in immunology

authors： Crawford A,Wherry EJ

更新日期：2009-04-01 00:00:00

abstract：:Dicer is a multifunctional protein that is essential across species for the generation of microRNAs, a function that is highly conserved across the plant and animal kingdoms. Intriguingly, Dicer exhibits antiviral functions in lower organisms including Drosophila melanogaster and Caenorhabditis elegans. Antiviral acti...

journal_title：Current opinion in immunology

authors： MacKay CR,Wang JP,Kurt-Jones EA

更新日期：2014-02-01 00:00:00

abstract：:NKT cells utilize a restricted alphabeta TCR repertoire that recognizes glycolipids in association with CD1d. The recent development of fluorescent CD1d tetramers loaded with the synthetic glycolipid alpha-galactosyl-ceramide has led to a clearer definition of NKT-cell subsets as well as important insights into their ...

journal_title：Current opinion in immunology

authors： MacDonald HR

更新日期：2002-04-01 00:00:00

abstract：:Recent advances in mass spectrometry technology have facilitated detailed examination of MHC-II immunopeptidomes, for example the repertoires of peptides bound to MHC-II molecules expressed in antigen presenting cells. These studies have deepened our view of MHC-II presentation. Other studies have broadened our view o...

journal_title：Current opinion in immunology

authors： Stern LJ,Santambrogio L

更新日期：2016-06-01 00:00:00

abstract：:The sensing of nucleic acids by pattern recognition receptors is a central feature of innate immunity and is mediated by two types of receptors, Toll-like receptors and cytosolic receptors. Indeed, DNA, be it pathogen-derived or self-derived, can potently trigger the innate immune system; and much attention has been f...

journal_title：Current opinion in immunology

authors： Yanai H,Savitsky D,Tamura T,Taniguchi T

更新日期：2009-02-01 00:00:00

abstract：:The commensal bacteria normally resident in the gastrointestinal tract represent an enormous pool of foreign antigen within the body. Although mechanical barriers limit entry of bacteria into the host, recent data suggest that T cells routinely interact with commensal bacteria using both antigen-specific and non-speci...

journal_title：Current opinion in immunology

authors： Nutsch KM,Hsieh CS

更新日期：2012-08-01 00:00:00

abstract：:The efficient induction of interferons alpha and beta (IFN-alpha/beta) in virus-infected cells is central to the antiviral response of a host and is regulated mainly at the level of gene transcription. Once produced, IFN-alpha/beta transmit signals to the cell interior via a specific receptor complex to induce an anti...

journal_title：Current opinion in immunology

authors： Taniguchi T,Takaoka A

更新日期：2002-02-01 00:00:00

abstract：:The hygiene hypothesis was initially formulated to explain the steep increase in the prevalence of allergies in Western societies observed over the past few decades. It proposes that the microbial environment interfaces with the innate immune system and modulates its ability to impart instructions to adaptive immune r...

journal_title：Current opinion in immunology

authors： Vercelli D

更新日期：2006-12-01 00:00:00

abstract：:Innate immunity, our inborn immediate defence mechanism, was thought for a long time to be non-specific and, consequently, research into innate mechanisms often took second place to research into adaptive immunity. In recent decades, however, the spotlight has shone on groundbreaking advances into mechanisms of innate...

journal_title：Current opinion in immunology

authors： Coutinho A,Poltorack A

更新日期：2003-12-01 00:00:00

abstract：:The breaking of tolerance or unresponsiveness to self-antigens, involving the activation of autoreactive lymphocytes, is a critical event leading to autoimmune diseases. The precise mechanisms by which this can occur are mostly unknown. Viruses have been implicated in this process, among other etiological factors, suc...

journal_title：Current opinion in immunology

authors： von Herrath MG,Oldstone MB

更新日期：1996-12-01 00:00:00

abstract：:Recent evidence indicates that genes required for antigen processing are present in the class II region of the MHC. Two new classes of MHC genes that may encode much of the machinery required in the class I (endogenous) antigen-processing pathway have been discovered. There is evidence that genes required in the class...

journal_title：Current opinion in immunology

authors： Monaco JJ

更新日期：1992-02-01 00:00:00

abstract：:The hypothesis that protein kinase C (PKC)-theta; plays an important role in T-lymphocyte activation, as indicated by numerous studies in cell lines, was recently confirmed in mice deficient in the expression of this enzyme. In response to TCR stimulation, peripheral T cells lacking PKC-theta; failed to activate NF-ka...

journal_title：Current opinion in immunology

authors： Arendt CW,Albrecht B,Soos TJ,Littman DR

更新日期：2002-06-01 00:00:00

abstract：:Viruses that establish persistent infections in their host, such as herpesviruses, adenoviruses or HIV, express proteins designed to pre-empt or evade recognition and elimination by MHC class I restricted CD8+ T lymphocytes. Notable discoveries during the annual period of review have demonstrated that, in principle, e...

journal_title：Current opinion in immunology

authors： Hengel H,Koszinowski UH

更新日期：1997-08-01 00:00:00

abstract：:Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-kappa B (nuclear factor kappa B) activation is accomplished by recruitin...

journal_title：Current opinion in immunology

authors： Dobbelaere DA,Küenzi P

更新日期：2004-08-01 00:00:00