Abstract:
:The hypothesis that protein kinase C (PKC)-theta; plays an important role in T-lymphocyte activation, as indicated by numerous studies in cell lines, was recently confirmed in mice deficient in the expression of this enzyme. In response to TCR stimulation, peripheral T cells lacking PKC-theta; failed to activate NF-kappaB and AP-1, and to express IL-2. This revealed a critical function for this PKC family member in linking membrane-proximal activation cascades to transcriptional responses governing T-cell activation. Although the molecular interactions in which PKC-theta; engages have not been fully delineated, insights from a variety of recent studies have permitted new models to be formulated regarding the mechanisms through which it achieves its unique effector functions.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Arendt CW,Albrecht B,Soos TJ,Littman DRdoi
10.1016/s0952-7915(02)00346-1subject
Has Abstractpub_date
2002-06-01 00:00:00pages
323-30issue
3eissn
0952-7915issn
1879-0372pii
S0952791502003461journal_volume
14pub_type
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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journal_title:Current opinion in immunology
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