Abstract：
:The germinal centre (GC) is a specialized cellular structure that forms in response to antigenic stimulation. It generates long-term humoral immunity through the production of memory B cells and long-lived antibody-secreting plasma cells. Conventional GCs form within secondary lymphoid organs, where networks of specialised stromal cells that form during embryogenesis act as the stage upon which the various GC immune cell players are brought together, nurtured and co-ordinated to generate a productive response. In non-lymphoid organs, ectopic GCs can form in response to persistent antigenic and inflammatory stimuli. Unlike secondary lymphoid tissues, non-lymphoid organs do not have a developmentally programmed stromal cell network capable of supporting the germinal centre reaction; therefore, the local tissue stroma must be remodelled by inflammatory stimuli in order to host a GC reaction. These ectopic GCs produce memory B cells and plasma cells that form a critical component of the humoral immune response.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Silva-Cayetano A,Linterman MAdoi
10.1016/j.coi.2020.03.007subject
Has Abstractpub_date
2020-04-20 00:00:00pages
26-33eissn
0952-7915issn
1879-0372pii
S0952-7915(20)30030-3journal_volume
64pub_type
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