Abstract：
:Natural Killer (NK) cells are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells. NK-cell function is regulated by activating and inhibitory surface receptors recognizing their ligands on transformed cells. Modulation of NK numbers and/or function by a variety of agents such as cytokines and monoclonal antibodies may result in enhanced anti-tumor activity. Recombinant cytokines (i.e., IL-15 and IL-2), antibodies blocking inhibitory receptors (i.e., KIR, NKG2A and TIGIT) and agonists delivering signals via CD137, NKG2D and CD16 stand out as the most suitable opportunities. These agents can be used to potentiate NKcell- mediated antibody-dependent cellular cytotoxicity (ADCC) against antibody-coated tumor cells, offering potential for multiple combinatorial immunotherapy strategies against cancer.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Muntasell A,Ochoa MC,Cordeiro L,Berraondo P,López-Díaz de Cerio A,Cabo M,López-Botet M,Melero Idoi
10.1016/j.coi.2017.01.003subject
Has Abstractpub_date
2017-04-01 00:00:00pages
73-81eissn
0952-7915issn
1879-0372pii
S0952-7915(17)30008-0journal_volume
45pub_type
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journal_title：Current opinion in immunology
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