Abstract:
:T cell activation leads to a segregation of plasma membrane domains to form TCR signalling clusters and eventually immunological synapses. At these T cell activation sites signalling protein networks reside in plasma membrane regions which adopt a highly ordered physical state. Studies of reconstituted model membranes suggest that aggregation of lipid raft-favouring membrane components may trigger this lipid ordering and condensation of membrane domains in T cells. Activation-induced protein-protein interactions such as anchorage to the cytoskeleton drive this condensation of the plasma membrane. Elucidating the functional role and specific molecular mechanisms of lipid ordering at these domains in the T cell activation cascade will be an essential element in understanding the transmission of outside signals into intracellular responses.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Harder T,Rentero C,Zech T,Gaus Kdoi
10.1016/j.coi.2007.05.002subject
Has Abstractpub_date
2007-08-01 00:00:00pages
470-5issue
4eissn
0952-7915issn
1879-0372pii
S0952-7915(07)00097-0journal_volume
19pub_type
杂志文章,评审abstract::A major problem in the analysis of vaccine candidates is the lack of any agreed upon surrogates of efficacy, which means that for diseases that depend on a strong T cell response (HIV, TB especially) the only option is to perform an efficacy trial, involving thousands of subjects, enormous costs, and years before the ...
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journal_title:Current opinion in immunology
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