Abstract:
:B-cell antigen receptor (BCR) signals are crucial for initiation of humoral immune responses and must be actively modulated and/or terminated in preparation for receipt of subsequent cues for progression. BCR signaling is also actively inhibited in autoreactive cells in which unresponsiveness is maintained by anergy. This serves to prevent cell activation and autoimmunity. Importantly, the feedback mechanisms that modulate and/or terminate signaling during normal antigen-induced B-cell activation appear to also be involved in maintaining B-cell anergy. In fact, it is suggested that anergy reflects nothing more than the normal inability of cells to respond to antigen following preceding stimulation of normal inhibitory feedback mechanisms. Thus, the time-honored two-signal hypothesis is almost certainly correct, with second signals being required to release the cell from inhibitory BCR-specific and trans-active feedback regulation.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Gauld SB,Merrell KT,Cambier JCdoi
10.1016/j.coi.2006.03.015subject
Has Abstractpub_date
2006-06-01 00:00:00pages
292-7issue
3eissn
0952-7915issn
1879-0372pii
S0952-7915(06)00063-Xjournal_volume
18pub_type
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journal_title:Current opinion in immunology
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