Abstract：
:Commensal bacterial communities residing within the intestinal lumen of mammals have evolved to flourish in this microenvironment. To preserve this niche, commensal bacteria act with the host to prevent colonization by invasive pathogens that induce inflammation and disrupt the intestinal niche commensal bacteria occupy. Thus, it is mutually beneficial to the host and commensal bacteria to inhibit a pathogen's ability to establish an infection. Commensal bacteria express factors that support colonization, maximize nutrient uptake, and produce metabolites that confer a survival advantage over pathogens. Further, commensal bacteria stimulate the host's immune defenses and drive tonic expression of anti-microbial factors. In combination, these mechanisms preserve the niche for commensal bacteria and assist the host in preventing infection.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Abt MC,Pamer EGdoi
10.1016/j.coi.2014.03.003subject
Has Abstractpub_date
2014-08-01 00:00:00pages
16-22eissn
0952-7915issn
1879-0372pii
S0952-7915(14)00048-Xjournal_volume
29pub_type
杂志文章,评审abstract：:The recent discovery of PTPN22 as a novel susceptibility gene in human type 1 diabetes and continued progress in defining genes in animal models of the disease mark a fruitful period in the field of type 1 diabetes genetics. In addition, the similarities of the genetic and functional aspects across species have been s...
journal_title：Current opinion in immunology
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abstract：:Follicular helper T cells provide signals that promote B cell development, proliferation, and production of affinity matured and appropriately isotype switched antibodies. In addition to their classical locations within B cell follicles and germinal centers therein, B cell helper T cells are also found in extrafollicu...
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.04.014
更新日期：2007-06-01 00:00:00
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journal_title：Current opinion in immunology
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doi：10.1016/j.coi.2008.05.007
更新日期：2008-10-01 00:00:00
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2009.12.009
更新日期：2010-06-01 00:00:00
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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abstract：:The germinal center (GC) is an important anatomical site for the development of high affinity antibodies during T-cell dependent B cell responses. Although the importance of the GC response to humoral immunity is well known, much remains to be elucidated about GC induction, maintenance and regulation. Recent studies e...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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abstract：:The surface and lining tissues of our body are exposed to the external environment, and as such these epithelial tissues must form structural barriers able to defend against microbes, environmental toxins, and mechanical stress. Their cells are equipped to detect a diverse array of surface perturbations, and then laun...
journal_title：Current opinion in immunology
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abstract：:Defensins are a component of the host response against bacterial infections. Multiple studies suggest a linked upregulation of beta-defensins and pro-inflammatory cytokines expression in various tissues, as well as the possibility of mutual induction. Recent data demonstrate the importance of nucleotide-binding oligom...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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abstract：:The adoptive transfer of T cells isolated or engineered to have specificity for diseased cells represents an ideal approach for the targeted therapy of human viral and malignant diseases. The therapeutic potential of adoptive T cell therapy for infections and cancer was demonstrated in rodent models long ago, but the ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2009-04-01 00:00:00
