Abstract：
:Diseases due to defect in tolerance induction such as allergy, celiac disease, or Type 1 Diabetes develop mostly in childhood indicating the necessity of early intervention for primary prevention. Epidemiological studies report that breastfeeding could protect from these diseases. However, data are controversial and the mechanisms unclear. Experimental data suggest that breastfeeding-induced protection might rely on tolerance induction as long as some criteria are fulfilled. Thus, the tolerogenic potential of breast milk would depend on maternal exposure to common environmental and dietary antigens and the efficiency of antigen transfer across mammary epithelium. Induction of tolerance upon breast milk-mediated antigen transfer will also depend on the presence of immunomodulatory factors in breast milk and of its impact on neonatal gut and immune system maturation. The better understanding of maternal influence on tolerance induction through breastfeeding should allow the development of new strategies to prevent immune-mediated diseases.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Verhasselt Vdoi
10.1016/j.coi.2010.08.008subject
Has Abstractpub_date
2010-10-01 00:00:00pages
623-30issue
5eissn
0952-7915issn
1879-0372pii
S0952-7915(10)00117-2journal_volume
22pub_type
杂志文章,评审abstract：:Vaccines have been developed and deployed against several important bacterial pathogens of humans, including Neisseria meningitidis, Bordetella pertussis, Streptococcus pneumoniae and Mycobacterium tuberculosis. These vaccines are generally considered a successful public health measure and are effective at controlling...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2015.04.002
更新日期：2015-10-01 00:00:00
abstract：:The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least thr...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(99)00060-6
更新日期：2000-02-01 00:00:00
abstract：:Self-antigen-MHC complexes expressed by thymic stromal cells serve as ligands for TCR-mediated positive and negative selection, resulting in a self-MHC-restricted, self-tolerant T cell repertoire. It has recently become apparent that thymic stromal cells differ in their accessibility to antigen as well as their abilit...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(99)00069-2
更新日期：2000-04-01 00:00:00
abstract：:Although autoantigen-induced negative selection plays an important role in shaping the mature B-cell repertoire, studies in recent years have suggested that differentiation into any of the three mature B-cell subsets (marginal zone B cells, follicular B cells and B-1 B cells) is not a passive product of autoreactive B...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2004.01.006
更新日期：2004-04-01 00:00:00
abstract：:The canonical NF-κB pathway instructs the expression of inflammatory genes by the RelA:p50 transcription factor in response to diverse cell-activating stimuli. However, this mainstay RelA:p50 transcriptional output must also be curated so as to provide for stimulus-type-specific and cell-type-specific inflammatory res...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2020.08.005
更新日期：2020-09-05 00:00:00
abstract：:Gene expression variation is critical for the normal development and physiology of immune cells. Using cDNA microarrays, a systematic, genomic-scale view of gene expression in immune cells at many stages of differentiation and activation can be obtained. From the high vantagepoint provided by this technology, the gene...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(99)00078-3
更新日期：2000-04-01 00:00:00
abstract：:Recent studies have increased our understanding of the nature of autoimmune recognition and of the identity of autoantigens, at least in model systems. Knowledge of the autoantigens and the process of recognition is suggesting new therapies for autoimmune disease. ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(91)90071-8
更新日期：1991-02-01 00:00:00
abstract：:The discovery of the CD1 antigen-presenting system reveals that T cells survey the lipid content of target cells via T-cell receptor (TCR) contact with CD1 bound to lipids, glycolipids and small molecules. Recently, CD1 proteins have been found to present mycobacterial lipopeptides that are involved in scavenging iron...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2005.04.006
更新日期：2005-06-01 00:00:00
abstract：:Herpes zoster is common in older and immune suppressed persons due to diminished VZV-specific cellular immunity. A recombinant herpes zoster vaccine (RZV) consisting of a single VZV glycoprotein and an adjuvant system stimulates robust and persistent VZV-specific antibody and CD4+ T cell responses in these high-risk p...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2019.02.009
更新日期：2019-08-01 00:00:00
abstract：:The Notch family of evolutionarily conserved proteins regulates a broad spectrum of cell-fate decisions and differentiation processes during fetal and post-natal development. The best characterized role of Notch signaling during mammalian hematopoiesis and lymphopoiesis is the essential function of the Notch1 receptor...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2004.01.002
更新日期：2004-04-01 00:00:00
abstract：:Current models suggest that continuous antigenic stimulation of memory B cells is required to maintain long-term antibody production. In view of recent developments concerning plasma cell longevity, a new model is described that incorporates the important role of long-lived plasma cells in sustaining persistent antibo...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(98)80162-3
更新日期：1998-06-01 00:00:00
abstract：:B-cell antigen receptor (BCR) signals are crucial for initiation of humoral immune responses and must be actively modulated and/or terminated in preparation for receipt of subsequent cues for progression. BCR signaling is also actively inhibited in autoreactive cells in which unresponsiveness is maintained by anergy. ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2006.03.015
更新日期：2006-06-01 00:00:00
abstract：:The proteasome is the protein destroying machinery conserved in all eukaryotes and plays essential roles in various cellular processes. Apart from the conserved 'standard' proteasome, a special type of proteasome called 'immunoproteasome' exists in vertebrates for better presentation of antigenic peptides on MHC class...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2008.03.002
更新日期：2008-04-01 00:00:00
abstract：:Expression of some tumor-associated carbohydrate antigens may define the stage, rate and phenotype of tumor progression and may have prognostic value. Some of these antigens are now recognized as adhesion molecules that define the site of metastasis. Monoclonal antibodies to tumor-associated carbohydrate antigens, or ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(91)90091-e
更新日期：1991-10-01 00:00:00
abstract：:Physiological cell death, which occurs as a continuous byproduct of cellular turnover, is non-immunogenic or even tolerogenic, thereby avoiding autoimmunity. By contrast, cancer cell death elicited by radiotherapy and some chemotherapeutic agents such as anthracyclines is immunogenic. Recent data suggest that innate a...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2008.05.007
更新日期：2008-10-01 00:00:00
abstract：:The steep rise in the incidence and prevalence of food allergy (FA) in the last few decades have focused attention of environmental mechanisms which act to promote disease, chief among which is the microbiome. Recent studies have now established the presence of pathogenic dysbiosis in FA that could be precipitated by ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2019.06.001
更新日期：2019-10-01 00:00:00
abstract：:T cells are spared from programmed cell death in the thymus after an appropriate interaction between the T-cell receptor and a self peptide/MHC complex; this step is referred to as positive selection. Recent work has focused on precise identification of the positively selecting ligand, and the cell that presents it. F...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(94)90101-5
更新日期：1994-04-01 00:00:00
abstract：:Activated T cells undergo metabolic reprogramming which promotes glycolytic flux and lactate production as well as elevated production of lipids, proteins, nucleic acids and other carbohydrates (i.e. induction of biomass) even in the presence of oxygen. Activated T cells show induced expression of, among other things,...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2014.01.006
更新日期：2014-04-01 00:00:00
abstract：:The past few years have seen significant growth in the number of known chemokines. Along with expansion in this field has come an appreciation of a role for chemokines beyond the chemotaxis of leukocytes. In particular, it appears that these molecules may represent major products of activated lymphocytes and that, in ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(96)80123-3
更新日期：1996-06-01 00:00:00
abstract：:Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is respon...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(97)80166-5
更新日期：1997-02-01 00:00:00
abstract：:Proteasomes are large multicatalytic proteinase complexes which are responsible for the selective degradation of cellular proteins and the production of peptides for antigen presentation. Proteasomes are localized both in the nucleus and in the cytoplasm, where some are associated with the endoplasmic reticulum membra...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(98)80040-x
更新日期：1998-02-01 00:00:00
abstract：:Rational selection of individual adjuvants can often be made on the basis of innate molecular interactions of the foreign molecules with pattern recognition receptors such as Toll-like receptors. For example, monophosphoryl lipid A, a family of endotoxic TLR4 agonist molecules from bacteria, has recently been formulat...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2012.03.008
更新日期：2012-06-01 00:00:00
abstract：:Dendritic cells (DCs) with their potent antigen presenting ability are long considered as critical factor in antitumor immunity. Despite high potential in promoting antitumor responses, tumor-associated DCs are largely defective in their functional activity and can contribute to immune suppression in cancer. In recent...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2017.01.002
更新日期：2017-04-01 00:00:00
abstract：:One of the areas of greatest recent progress in immunology has been the elucidation of inhibitory receptors and their mode of signal transduction. A common feature of members of this growing family is expression of a conserved cytoplasmic sequence motif, the immunoreceptor tyrosine-based inhibitory motif, which functi...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(00)00092-3
更新日期：2000-06-01 00:00:00
abstract：:The adoptive transfer of T cells engineered to express artificial chimeric antigen receptors CARs) that target a tumor cell surface molecule has emerged as an exciting new approach for cancer immunotherapy. Clinical trials in patients with advanced B cell malignancies treated with CD19-specific CAR-modified T cells (C...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2015.01.002
更新日期：2015-04-01 00:00:00
abstract：:A major problem in the analysis of vaccine candidates is the lack of any agreed upon surrogates of efficacy, which means that for diseases that depend on a strong T cell response (HIV, TB especially) the only option is to perform an efficacy trial, involving thousands of subjects, enormous costs, and years before the ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2020.05.002
更新日期：2020-08-01 00:00:00
abstract：:Epstein-Barr virus induces a potent cytotoxic T lymphocyte response in man that is preferentially directed towards a particular subset of the virus latent cycle antigens; the immunodominance of these proteins, apparent in both primary and memory responses, may reflect some differential access to the HLA class I proces...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(96)80036-7
更新日期：1996-08-01 00:00:00
abstract：:Recent evidence indicates that genes required for antigen processing are present in the class II region of the MHC. Two new classes of MHC genes that may encode much of the machinery required in the class I (endogenous) antigen-processing pathway have been discovered. There is evidence that genes required in the class...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(92)90128-2
更新日期：1992-02-01 00:00:00
abstract：:MHC class I molecules present degradation products derived from intracellular proteins, whereas MHC class II molecules generally present peptides derived from extracellular or surface proteins. Recent insights into the cell biology of MHC class I and II molecules explain this difference. ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(93)90077-6
更新日期：1993-02-01 00:00:00
abstract：:Germinal centers (GCs) are well known for their important role in shaping the secondary B cell repertoire to generate antibodies capable of binding with high-affinity and specificity to foreign antigens. Somatic hypermutation of the Ig variable region genes in GC B cells represents a highly efficient mechanism for gen...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2019.11.001
更新日期：2020-04-01 00:00:00
