Abstract:
:Most viral vaccines provide protection from infection through the generation of neutralizing antibodies (nAbs). The repertoire of B cells responding to immunization is the starting material from which nAbs eventually arise. Immunization strategies are increasingly targeting precise B cell specificities to mimic nAbs generated during natural infection, in an effort to maximize the potency of the vaccine-elicited Ab response. An understanding of the human B cell specificities capable of immunogen recognition can aid in immunogen design and inform decision-making for clinical advancement. Here, we review what is known about antigen-specific and epitope-specific naive B cell repertoires in humans and mice, and we consider the challenges for identifying and analyzing antigen-specific naive B cell repertoires. Finally, we provide a framework for further exploration, interpretation, utilization of the B cell repertoire to facilitate vaccine discovery.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Havenar-Daughton C,Abbott RK,Schief WR,Crotty Sdoi
10.1016/j.coi.2018.08.002subject
Has Abstractpub_date
2018-08-01 00:00:00pages
209-216eissn
0952-7915issn
1879-0372pii
S0952-7915(17)30207-8journal_volume
53pub_type
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