The development of LTi cells.

abstract：:Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in ...

journal_title：Current opinion in immunology

authors： Choi J,Kim ST,Craft J

更新日期：2012-12-01 00:00:00

abstract：:Current models suggest that continuous antigenic stimulation of memory B cells is required to maintain long-term antibody production. In view of recent developments concerning plasma cell longevity, a new model is described that incorporates the important role of long-lived plasma cells in sustaining persistent antibo...

journal_title：Current opinion in immunology

authors： Slifka MK,Ahmed R

更新日期：1998-06-01 00:00:00

abstract：:The identification of human papillomavirus as the etiological factor for cervical cancer provides an opportunity to treat these malignancies by vaccination. Although therapeutic vaccination against viral oncogenes regularly induces a specific T cell response, clinical effectivity remains low. Three factors are particu...

journal_title：Current opinion in immunology

authors： van der Sluis TC,van der Burg SH,Arens R,Melief CJ

更新日期：2015-08-01 00:00:00

abstract：:The past year has seen the publication of significant new findings on the regulation of CD23 expression, the precise interaction of CD23 with CD21 and its functional consequences. Moreover, new advances have been made in unravelling the biochemical network of events downstream from the triggering of CD23 in human B ce...

journal_title：Current opinion in immunology

authors： Bonnefoy JY,Lecoanet-Henchoz S,Aubry JP,Gauchat JF,Graber P

更新日期：1995-06-01 00:00:00

abstract：:Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein to orchestrate the innate host response to pathogen, ultimately leading to the induction of antiviral and inflammatory responses mediated by t...

journal_title：Current opinion in immunology

authors： Belgnaoui SM,Paz S,Hiscott J

更新日期：2011-10-01 00:00:00

abstract：:Malaria remains one of the greatest impediments to development in many tropical regions of the world. Understanding host immune responses to malaria parasites is crucial for the effective design and implementation of new vaccines and drugs. Recent research has seen the identification of the first pattern recognition r...

journal_title：Current opinion in immunology

authors： Engwerda CR,Good MF

更新日期：2005-08-01 00:00:00

abstract：:The past year has been refinement in our ability to delay the progression of human immunodeficiency virus type 1 infection through the use of nucleoside analogues, singly or in combination. Progress has also been made in our ability to detect drug-resistant isolates of human immunodeficiency virus type 1 and to begin ...

journal_title：Current opinion in immunology

authors： Lane HC

更新日期：1992-08-01 00:00:00

abstract：:The discovery of defined tumor antigens and their application in therapeutic cancer vaccines has not yet resulted in a successful therapy for cancer patients. Recent data suggest that this might be because most current clinical immunotherapeutic strategies rely on a tolerized tumor-reactive T-cell repertoire, resultin...

journal_title：Current opinion in immunology

authors： Overwijk WW

更新日期：2005-04-01 00:00:00

abstract：:A diverse B cell repertoire is essential for an effective immune response. Not only to provide a variety of antibodies to recognise the multiplicity of likely pathogen challenge, but also because B cells are important regulators of the immune response. In addition to their excellent capabilities as antigen presenting ...

journal_title：Current opinion in immunology

authors： Dunn-Walters DK,Ademokun AA

更新日期：2010-08-01 00:00:00

abstract：:The strong genetic association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spondylitis (AS), which is restricted to HLA-B27 positive cases, has profound pathogenetic implications. ERAP1 is involved in trimming peptides to optimal length for binding to HLA class 1 molecules, thereby not only affec...

journal_title：Current opinion in immunology

authors： Keidel S,Chen L,Pointon J,Wordsworth P

更新日期：2013-02-01 00:00:00

abstract：:Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-kappa B (nuclear factor kappa B) activation is accomplished by recruitin...

journal_title：Current opinion in immunology

authors： Dobbelaere DA,Küenzi P

更新日期：2004-08-01 00:00:00

abstract：:Type I and type II interferons (IFNα/β and IFNγ) are cytokines that play indispensable roles in directing myeloid cell activity during inflammatory and immune responses. Each IFN type binds a distinct receptor (IFNAR or IFNGR) to transduce signals that reshape gene expression and function of myeloid and other cell typ...

journal_title：Current opinion in immunology

authors： Crisler WJ,Lenz LL

更新日期：2018-10-01 00:00:00

abstract：:Two years ago, T helper cells, including Th1, Th2 and Th17 cells, were considered to be the most significant sources of cytokine during the orchestration of immune responses in the lung. Following the discovery of innate lymphoid cells, we now know that these previously unappreciated cytokine-secreting cells, includin...

journal_title：Current opinion in immunology

authors： Scanlon ST,McKenzie AN

更新日期：2012-12-01 00:00:00

abstract：:The hypothesis that protein kinase C (PKC)-theta; plays an important role in T-lymphocyte activation, as indicated by numerous studies in cell lines, was recently confirmed in mice deficient in the expression of this enzyme. In response to TCR stimulation, peripheral T cells lacking PKC-theta; failed to activate NF-ka...

journal_title：Current opinion in immunology

authors： Arendt CW,Albrecht B,Soos TJ,Littman DR

更新日期：2002-06-01 00:00:00

abstract：:Since the establishment of methods to isolate genes encoding cytotoxic T lymphocyte defined tumor antigens, several antigens have been identified and characterized for suitability as target antigens for immunotherapy. The development of innovative strategies to generate T cells targeting these antigens and lessons lea...

journal_title：Current opinion in immunology

authors： Yee C,Riddell SR,Greenberg PD

更新日期：1997-10-01 00:00:00

abstract：:Antibody deficiencies are the most prevalent forms of primary immunodeficiencies (PIDs). Several disease-causing mutations have been identified to date, but still, the genetic background of most patients remains elusive. During the last 2 years, next generation sequencing has revealed the genetic basis for a number of...

journal_title：Current opinion in immunology

authors： Liadaki K,Sun J,Hammarström L,Pan-Hammarström Q

更新日期：2013-10-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection is a global health problem. There are >350 million of people chronically infected with this virus worldwide. Hepatitis B vaccines are effective in preventing the infection. Humoral immunity is the key factor in conferring the protection. Hepatitis B surface antibody titers of ≥10mIU/m...

journal_title：Current opinion in immunology

authors： Huang LM,Lu CY,Chen DS

更新日期：2011-04-01 00:00:00

abstract：:Applications of the polymerase chain reaction have revolutionized the field of immunogenetics, particularly in studies of human leukocyte antigen class II polymorphism, and more recently in the analysis of T-cell receptor usage. However, the enormous diversity and variability of the T-cell receptor complex have made t...

journal_title：Current opinion in immunology

authors： Panzara MA,Oksenberg JR,Steinman L

更新日期：1992-04-01 00:00:00

abstract：:Within a few years of the discovery of Toll-like receptors (TLRs) and their role in innate immunity, viral and bacterial proteins were recognized to antagonize TLR signal transduction. Since then, as TLR signaling networks were unraveled, microbial systems have been discovered that target nearly every component within...

journal_title：Current opinion in immunology

authors： Rosadini CV,Kagan JC

更新日期：2015-02-01 00:00:00

abstract：:Cytokines have been presumed to play an important role during T-cell development, but until recently formal proof has been missing. Most cytokine-knockout mice show apparently normal intrathymic T-cell development. The exception to this is IL-7, as both IL-7 and IL-7R alpha knockout mice show abnormally low thymic cel...

journal_title：Current opinion in immunology

authors： Zlotnik A,Moore TA

更新日期：1995-04-01 00:00:00

abstract：:Various new aspects of antigen processing have been uncovered through the study of tumor antigens. One of these is the production of antigenic peptides by splicing of two distinct peptide fragments. In one of the two cases reported, the proteasome was found to be responsible for splicing. The presentation of another p...

journal_title：Current opinion in immunology

authors： van der Bruggen P,Van den Eynde BJ

更新日期：2006-02-01 00:00:00

abstract：:V(D)J recombination can be separated into two basic operations: DNA cleavage and joining of broken ends. Our understanding of both reactions has increased substantially in the past year. Major advances include the development of a cell-free system capable of cleavage and the identification of several proteins involved...

journal_title：Current opinion in immunology

authors： Bogue M,Roth DB

更新日期：1996-04-01 00:00:00

abstract：:The surface and lining tissues of our body are exposed to the external environment, and as such these epithelial tissues must form structural barriers able to defend against microbes, environmental toxins, and mechanical stress. Their cells are equipped to detect a diverse array of surface perturbations, and then laun...

journal_title：Current opinion in immunology

authors： Larsen SB,Cowley CJ,Fuchs E

更新日期：2020-02-01 00:00:00

abstract：:The past year provided a number of challenges to our expectations regarding hematopoietic stem cell (HSC) biology. Evidence has emerged that HSCs arise intraembryonically before they can be detected in the yolk sac. A number of genes that may regulate the formation, self-renewal, or differentiation of HSC have been id...

journal_title：Current opinion in immunology

authors： Morrison SJ,Wright DE,Cheshier SH,Weissman IL

更新日期：1997-04-01 00:00:00

abstract：:Proteasomes are large multicatalytic proteinase complexes which are responsible for the selective degradation of cellular proteins and the production of peptides for antigen presentation. Proteasomes are localized both in the nucleus and in the cytoplasm, where some are associated with the endoplasmic reticulum membra...

journal_title：Current opinion in immunology

authors： Rivett AJ

更新日期：1998-02-01 00:00:00

abstract：:Suppressor T cells down-regulate the activity of other cells in the immune system, and, albeit controversial, are believed to play a role in immunological tolerance and immunoregulation. Significant progress has been made in characterizing suppressor T cells and their receptors, and in elucidating mechanisms of immuno...

journal_title：Current opinion in immunology

authors： Murphy DB

更新日期：1993-06-01 00:00:00

abstract：:A strong skeleton relies on adaptation to varying physical demands and on maintenance of the bone tissue in order to avoid accumulation of micro-damage. In bone, the purinergic P2X7 ion channel receptor is expressed on both cells of the stromal lineage such as the bone forming osteoblasts and the mechano-sensing osteo...

journal_title：Current opinion in immunology

authors： Jørgensen NR

更新日期：2018-06-01 00:00:00

abstract：:Rheumatoid arthritis is often considered to be an autoimmune disease in which the abnormal immunological response is triggered by an infectious agent(s) but progress towards identifying such extrinsic factors has so far been unrevealing. In contrast, the genetic component of host susceptibility is slowly becoming clea...

journal_title：Current opinion in immunology

authors： Wordsworth P

更新日期：1992-12-01 00:00:00

abstract：:Recent advances in the field of cellular therapy have focused on autologous T cells engineered to express a chimeric antigen receptor (CAR) against tumor antigens. Remarkable responses have been observed in patients receiving autologous CD19-redirected T cells for the treatment of B-lymphoid malignancies. However, the...

journal_title：Current opinion in immunology

authors： Daher M,Rezvani K

更新日期：2018-04-01 00:00:00

abstract：:Much has been learned recently about the structure and function of 55 kDa bactericidal/permeability-increasing protein (BPI), a member of a genomically conserved lipid-interactive protein family. Analysis of BPI fragments and the crystal structure of human BPI have established that BPI consists of two functionally dis...

journal_title：Current opinion in immunology

authors： Elsbach P,Weiss J

更新日期：1998-02-01 00:00:00