Bullous skin diseases.

abstract：:Follicular helper T cells provide signals that promote B cell development, proliferation, and production of affinity matured and appropriately isotype switched antibodies. In addition to their classical locations within B cell follicles and germinal centers therein, B cell helper T cells are also found in extrafollicu...

journal_title：Current opinion in immunology

authors： Seth A,Craft J

更新日期：2019-12-01 00:00:00

abstract：:The adoptive transfer of T cells isolated or engineered to have specificity for diseased cells represents an ideal approach for the targeted therapy of human viral and malignant diseases. The therapeutic potential of adoptive T cell therapy for infections and cancer was demonstrated in rodent models long ago, but the ...

journal_title：Current opinion in immunology

authors： Berger C,Turtle CJ,Jensen MC,Riddell SR

更新日期：2009-04-01 00:00:00

abstract：:B-cell antigen receptor (BCR) signals are crucial for initiation of humoral immune responses and must be actively modulated and/or terminated in preparation for receipt of subsequent cues for progression. BCR signaling is also actively inhibited in autoreactive cells in which unresponsiveness is maintained by anergy. ...

journal_title：Current opinion in immunology

authors： Gauld SB,Merrell KT,Cambier JC

更新日期：2006-06-01 00:00:00

abstract：:Dendritic cells (DC) are heterogenous, comprising several subpopulations of migratory and lymphoid-organ-resident types. Recent studies addressing the role of each subset in antigen presentation in vivo have revealed a complex division of labor within the DC network. In addition to CD8(+) DC, migratory lung or dermal ...

journal_title：Current opinion in immunology

authors： Segura E,Villadangos JA

更新日期：2009-02-01 00:00:00

abstract：:Thymocytes co-expressing the CD4 and CD8 co-receptors differentiate into mature T cells that express either CD4 or CD8 and have helper or cytotoxic functions, respectively. Recent studies indicate that commitment to the CD4+ or CD8+ lineages occurs stochastically, but retention of the appropriate co-receptor is requir...

journal_title：Current opinion in immunology

authors： Davis CB,Littman DR

更新日期：1994-04-01 00:00:00

abstract：:Herpes zoster is common in older and immune suppressed persons due to diminished VZV-specific cellular immunity. A recombinant herpes zoster vaccine (RZV) consisting of a single VZV glycoprotein and an adjuvant system stimulates robust and persistent VZV-specific antibody and CD4+ T cell responses in these high-risk p...

journal_title：Current opinion in immunology

authors： Heineman TC,Cunningham A,Levin M

更新日期：2019-08-01 00:00:00

abstract：:The identification of human papillomavirus as the etiological factor for cervical cancer provides an opportunity to treat these malignancies by vaccination. Although therapeutic vaccination against viral oncogenes regularly induces a specific T cell response, clinical effectivity remains low. Three factors are particu...

journal_title：Current opinion in immunology

authors： van der Sluis TC,van der Burg SH,Arens R,Melief CJ

更新日期：2015-08-01 00:00:00

abstract：:Defensins are a component of the host response against bacterial infections. Multiple studies suggest a linked upregulation of beta-defensins and pro-inflammatory cytokines expression in various tissues, as well as the possibility of mutual induction. Recent data demonstrate the importance of nucleotide-binding oligom...

journal_title：Current opinion in immunology

authors： Menendez A,Brett Finlay B

更新日期：2007-08-01 00:00:00

abstract：:Infectious diseases are the result of the exposure of susceptible hosts to pathogenic microbes. Genetic factors are important determinants of host susceptibility and efforts are being made to establish the molecular identity of such genetic susceptibility variants by genome-wide association studies. Results obtained t...

journal_title：Current opinion in immunology

authors： Abel L,Alcaïs A,Schurr E

更新日期：2014-10-01 00:00:00

abstract：:Discovered during the past ten years, Janus kinases and signal transducers and activators of transcription have emerged as critical elements in cytokine signaling and immunoregulation. Recently, knockout mice for all the members of these families have been generated, with remarkably specific outcomes. Equally exciting...

journal_title：Current opinion in immunology

authors： Gadina M,Hilton D,Johnston JA,Morinobu A,Lighvani A,Zhou YJ,Visconti R,O'Shea JJ

更新日期：2001-06-01 00:00:00

abstract：:Chronic non-communicable diseases (NCDs) are increasingly recognized as the major cause of morbidity and mortality worldwide. Effective, affordable and broadly accessible medicines for their treatment are much sought after. Therapeutic B-cell vaccines aim at inducing neutralizing auto-reactive antibodies against impor...

journal_title：Current opinion in immunology

authors： Röhn TA,Bachmann MF

更新日期：2010-06-01 00:00:00

abstract：:Dendritic cells (DCs) with their potent antigen presenting ability are long considered as critical factor in antitumor immunity. Despite high potential in promoting antitumor responses, tumor-associated DCs are largely defective in their functional activity and can contribute to immune suppression in cancer. In recent...

journal_title：Current opinion in immunology

authors： Veglia F,Gabrilovich DI

更新日期：2017-04-01 00:00:00

abstract：:Consolidating the information that we have on pharmacogenetics and on cytokine genetics to produce patient-oriented individualized drug regimens is an important challenge in transplantation medicine. Using a multi-variant approach based on genetic profile and other relevant clinical factors a score system may be devel...

journal_title：Current opinion in immunology

authors： Girnita DM,Burckart G,Zeevi A

更新日期：2008-10-01 00:00:00

abstract：:During the past couple of years there has been significant progress in our understanding of the development of different lineages of T cells within the thymus. Pathways, subpopulations and cellular dynamics are all becoming clearer. Signal transduction through primary and accessory receptors is also beginning to be un...

journal_title：Current opinion in immunology

authors： Scollay R

更新日期：1991-04-01 00:00:00

abstract：:The identification and quantitation of peptides selected by class II MHC molecules during natural processing of proteins is of key importance in understanding the repertoire and distribution of T cells. The examination of peptides selected by class II MHC molecules has depended greatly on mass spectrometry, a powerful...

journal_title：Current opinion in immunology

authors： Suri A,Lovitch SB,Unanue ER

更新日期：2006-02-01 00:00:00

abstract：:Various new aspects of antigen processing have been uncovered through the study of tumor antigens. One of these is the production of antigenic peptides by splicing of two distinct peptide fragments. In one of the two cases reported, the proteasome was found to be responsible for splicing. The presentation of another p...

journal_title：Current opinion in immunology

authors： van der Bruggen P,Van den Eynde BJ

更新日期：2006-02-01 00:00:00

abstract：:The sensing of nucleic acids by pattern recognition receptors is a central feature of innate immunity and is mediated by two types of receptors, Toll-like receptors and cytosolic receptors. Indeed, DNA, be it pathogen-derived or self-derived, can potently trigger the innate immune system; and much attention has been f...

journal_title：Current opinion in immunology

authors： Yanai H,Savitsky D,Tamura T,Taniguchi T

更新日期：2009-02-01 00:00:00

abstract：:The recent discovery of PTPN22 as a novel susceptibility gene in human type 1 diabetes and continued progress in defining genes in animal models of the disease mark a fruitful period in the field of type 1 diabetes genetics. In addition, the similarities of the genetic and functional aspects across species have been s...

journal_title：Current opinion in immunology

authors： Maier LM,Wicker LS

更新日期：2005-12-01 00:00:00

abstract：:Commensal bacterial communities residing within the intestinal lumen of mammals have evolved to flourish in this microenvironment. To preserve this niche, commensal bacteria act with the host to prevent colonization by invasive pathogens that induce inflammation and disrupt the intestinal niche commensal bacteria occu...

journal_title：Current opinion in immunology

authors： Abt MC,Pamer EG

更新日期：2014-08-01 00:00:00

abstract：:The diverse αβ T cell receptor (TCR) repertoire exhibits versatility in its ability to generate antigen (Ag) receptors capable of interacting with polymorphic Major Histocompatibility Complex (MHC) molecules and monomorphic MHC-I like molecules, including the CD1 and MR1 families. Collectively, these evolutionarily re...

journal_title：Current opinion in immunology

authors： Eckle SB,Turner SJ,Rossjohn J,McCluskey J

更新日期：2013-10-01 00:00:00

abstract：:The ensemble of antibodies found in serum and secretions represents the key adaptive component of B-cell mediated humoral immunity. The antibody repertoire is shaped by the historical record of exposure to exogenous factors such as pathogens and vaccines, as well as by endogenous host-intrinsic factors such as genetic...

journal_title：Current opinion in immunology

authors： Wine Y,Horton AP,Ippolito GC,Georgiou G

更新日期：2015-08-01 00:00:00

abstract：:The use of colony stimulating factors in clinical bone marrow transplantation is rapidly evolving. Both granulocyte colony stimulating factor and granulocyte macrophage colony stimulating factor have shown efficacy in bone marrow transplant patients in accelerating the rate of myeloid recovery. The use of colony stimu...

journal_title：Current opinion in immunology

authors： Negrin RS,Greenberg PL

更新日期：1992-10-01 00:00:00

abstract：:Until very recently, the function of CD14 was thought to be limited to innate immune responses to bacterial and other microbial structures. It is now known that macrophage CD14 serves an additional unexpected function, namely as a receptor involved in the recognition and phagocytosis of cells undergoing apoptosis. In ...

journal_title：Current opinion in immunology

authors： Gregory CD

更新日期：2000-02-01 00:00:00

abstract：:Gene therapy has become an attractive alternative therapeutic strategy to allogeneic transplant for primary immunodeficiencies (PIDs) owing to known genetic defects. Clinical trials using gammaretroviral vectors have demonstrated the proof of principle of gene therapy for Wiskott-Aldrich syndrome (WAS) and chronic gra...

journal_title：Current opinion in immunology

authors： Aiuti A,Bacchetta R,Seger R,Villa A,Cavazzana-Calvo M

更新日期：2012-10-01 00:00:00

abstract：:Current models suggest that continuous antigenic stimulation of memory B cells is required to maintain long-term antibody production. In view of recent developments concerning plasma cell longevity, a new model is described that incorporates the important role of long-lived plasma cells in sustaining persistent antibo...

journal_title：Current opinion in immunology

authors： Slifka MK,Ahmed R

更新日期：1998-06-01 00:00:00

abstract：:While Interleukin-5 (IL-5) is initially identified by its ability to support the growth and differentiation of activated B cells, overexpression of IL-5 significantly increases eosinophil numbers and antibody levels predominantly from an expanded population of B-1 cells in vivo. Conversely, mice lacking a functional g...

journal_title：Current opinion in immunology

authors： Takatsu K,Nakajima H

更新日期：2008-06-01 00:00:00

abstract：:Conceptually, a universal influenza vaccine should elicit broadly protective antibody responses targeting highly conserved epitope(s) shared by various virus strains. Strategically directing antibody immunity to the conserved hemagglutinin stalk has recently emerged as a promising approach that is substantiated by the...

journal_title：Current opinion in immunology

authors： Zhao C,Xu J

更新日期：2018-08-01 00:00:00

abstract：:Islets of Langerhans of all species harbor a small number of resident macrophages. These macrophages are found since birth, do not exchange with blood monocytes, and are maintained by a low level of replication. Under steady state conditions, the islet macrophages are in an activated state. Islet macrophages have an i...

journal_title：Current opinion in immunology

authors： Carrero JA,Ferris ST,Unanue ER

更新日期：2016-12-01 00:00:00

abstract：:Murine gamma-herpesvirus 68 (gammaHV68) infection is a new model for understanding how immunity and chronic gamma-herpesvirus infection inter-relate. gammaHV68 is closely related to the human Epstein-Barr virus and Kaposi's sarcoma herpesvirus and is associated with tumors, vasculitis of the great elastic arteries and...

journal_title：Current opinion in immunology

authors： Virgin HW,Speck SH

更新日期：1999-08-01 00:00:00

abstract：:Activated T cells undergo metabolic reprogramming which promotes glycolytic flux and lactate production as well as elevated production of lipids, proteins, nucleic acids and other carbohydrates (i.e. induction of biomass) even in the presence of oxygen. Activated T cells show induced expression of, among other things,...

journal_title：Current opinion in immunology

authors： Maciolek JA,Pasternak JA,Wilson HL

更新日期：2014-04-01 00:00:00