The role of T helper subsets in autoimmunity and allergy.

abstract：:Murine gamma-herpesvirus 68 (gammaHV68) infection is a new model for understanding how immunity and chronic gamma-herpesvirus infection inter-relate. gammaHV68 is closely related to the human Epstein-Barr virus and Kaposi's sarcoma herpesvirus and is associated with tumors, vasculitis of the great elastic arteries and...

journal_title：Current opinion in immunology

authors： Virgin HW,Speck SH

更新日期：1999-08-01 00:00:00

abstract：:The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that these cells play a role...

journal_title：Current opinion in immunology

authors： Benabid A,Peduto L

更新日期：2020-05-06 00:00:00

abstract：:A little more than a decade after the explosion of research into recombinant live-attenuated or replication-deficient viruses as vaccine platforms, many viral vector-based vaccines have been licensed for animals. Progress has been slower for humans but 2011 will see the licensure of the first viral-vectored vaccine fo...

journal_title：Current opinion in immunology

authors： Rollier CS,Reyes-Sandoval A,Cottingham MG,Ewer K,Hill AV

更新日期：2011-06-01 00:00:00

abstract：:Multiple sclerosis (MS) and other autoimmune diseases result from the dysregulation of genetic and proteomic programs. In MS, the loss of immune homeostasis leads to aberrant targeting and destruction of the myelin sheath, which manifests as the clinical syndrome of MS. The advent of technologies to perform large-scal...

journal_title：Current opinion in immunology

authors： Robinson WH,Utz PJ,Steinman L

更新日期：2003-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in ...

journal_title：Current opinion in immunology

authors： Choi J,Kim ST,Craft J

更新日期：2012-12-01 00:00:00

abstract：:Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of the HLA locus. Genetic polymorphisms in these genes have recently been associated with effects on HIV-1 pathogenesis. The history and implicati...

journal_title：Current opinion in immunology

authors： Michael NL

更新日期：1999-08-01 00:00:00

abstract：:Type I and type II interferons (IFNα/β and IFNγ) are cytokines that play indispensable roles in directing myeloid cell activity during inflammatory and immune responses. Each IFN type binds a distinct receptor (IFNAR or IFNGR) to transduce signals that reshape gene expression and function of myeloid and other cell typ...

journal_title：Current opinion in immunology

authors： Crisler WJ,Lenz LL

更新日期：2018-10-01 00:00:00

abstract：:The development of novel vaccine candidates against infections with Mycobacterium tuberculosis has highlighted our limited understanding of immune mechanisms required to kill M. tuberculosis. The induction of a Th1 immunity is vital, but new studies are required to identify other mechanisms that may be necessary. Nove...

journal_title：Current opinion in immunology

authors： Izzo AA

更新日期：2017-08-01 00:00:00

abstract：:Self-antigen-MHC complexes expressed by thymic stromal cells serve as ligands for TCR-mediated positive and negative selection, resulting in a self-MHC-restricted, self-tolerant T cell repertoire. It has recently become apparent that thymic stromal cells differ in their accessibility to antigen as well as their abilit...

journal_title：Current opinion in immunology

authors： Klein L,Kyewski B

更新日期：2000-04-01 00:00:00

abstract：:Much has been learned recently about the structure and function of 55 kDa bactericidal/permeability-increasing protein (BPI), a member of a genomically conserved lipid-interactive protein family. Analysis of BPI fragments and the crystal structure of human BPI have established that BPI consists of two functionally dis...

journal_title：Current opinion in immunology

authors： Elsbach P,Weiss J

更新日期：1998-02-01 00:00:00

abstract：:Vaccines prophylactic against infection with human papillomavirus (HPV) are based on alum adjuvanted virus-like particles. Two such vaccines have recently been shown to prevent persistent HPV infection and associated cervical cancer precursor lesions. The genotype-specific neutralising antibody directed at conformatio...

journal_title：Current opinion in immunology

authors： Leggatt GR,Frazer IH

更新日期：2007-04-01 00:00:00

abstract：:Pig-to-primate organ survival has been extended from a few minutes to weeks and occasionally months, following the development of transgenic pigs that express human complement-regulatory proteins, efficient antibody removal technologies and immunosuppressive strategies. The current limitation to the clinical applicati...

journal_title：Current opinion in immunology

authors： Logan JS

更新日期：2000-10-01 00:00:00

abstract：:Induction of antiviral immunity in vertebrates and invertebrates relies on members of the RIG-I-like receptor and Dicer families, respectively. Although these proteins have different size and domain composition, members of both families share a conserved DECH-box helicase domain. This helicase, also known as a duplex ...

journal_title：Current opinion in immunology

authors： Paro S,Imler JL,Meignin C

更新日期：2015-02-01 00:00:00

abstract：:Human papillomaviruses (HPVs) have been associated with benign and malignant epithelial proliferations in either skin or mucosa. Two HPV oncogenic proteins, E6 and E7, are important in the induction and maintenance of cellular transformation and are co-expressed in the majority of HPV-containing carcinomas. Therefore,...

journal_title：Current opinion in immunology

authors： Wu TC

更新日期：1994-10-01 00:00:00

abstract：:In normal hematopoiesis, differentiation and maturation of cell populations belonging to various lineages are tightly regulated by the interaction of many transcription factors. The relative numbers of different myeloid cells depends on their proliferative/apoptotic rate, while their identity relates to their recruitm...

journal_title：Current opinion in immunology

authors： Sonda N,Chioda M,Zilio S,Simonato F,Bronte V

更新日期：2011-04-01 00:00:00

abstract：:MHC class I molecules present degradation products derived from intracellular proteins, whereas MHC class II molecules generally present peptides derived from extracellular or surface proteins. Recent insights into the cell biology of MHC class I and II molecules explain this difference. ...

journal_title：Current opinion in immunology

authors： Neefjes JJ,Momburg F

更新日期：1993-02-01 00:00:00

abstract：:Three known lineages of antigen-presenting molecules restrict T-cell responses to microbial antigens: MHC class I and MHC encoded class I like molecules present peptides derived from the proteolysis of intracellular pathogens, MHC class ii molecules present peptides derived from the proteolysis of extracellular pathog...

journal_title：Current opinion in immunology

authors： Melián A,Beckman EM,Porcelli SA,Brenner MB

更新日期：1996-02-01 00:00:00

abstract：:T cell antigen receptor-induced signals are required for normal T cell development and function. Recent studies have investigated the mechanism(s) by which signals of different strengths are converted into distinct cellular fates during thymocyte development. These studies indicate the importance of the strength and d...

journal_title：Current opinion in immunology

authors： Love PE,Chan AC

更新日期：2003-04-01 00:00:00

abstract：:Intimate interactions between multipotential hemopoietic stem cells and their microenvironment work towards redefining the identity and the differentiative fate of these primitive cells. Molecular cues delivered by the microenvironment frequently act in an instructive fashion by initiating intracellular signaling path...

journal_title：Current opinion in immunology

authors： Georgopoulos K

更新日期：1997-04-01 00:00:00

abstract：:Killer Ig-like receptors (KIRs) are surface inhibitory receptors specific for allelic forms of human leukocyte antigen (HLA) class I molecules, which are expressed by natural killer (NK) cells and a subset of T lymphocytes. Upon engagement with HLA class I molecules, KIRs block NK cell activation and function. Cells l...

journal_title：Current opinion in immunology

authors： Moretta L,Moretta A

更新日期：2004-10-01 00:00:00

abstract：:Rapid progress in the discovery of members of the tumor necrosis factor receptor/ligand superfamilies has been made, mainly with the help of massive DNA sequencing and bioinformatic studies. Biological studies of the new members have not only indicated overlapping roles with other members but also provided insights in...

journal_title：Current opinion in immunology

authors： Kwon B,Youn BS,Kwon BS

更新日期：1999-06-01 00:00:00

abstract：:Simply detecting the presence or absence of Foxp3, a transcription factor characteristic of naturally occurring CD4+ CD25+ regulatory T cells (Tregs), now appears of minimal value in predicting the outcome of immunologic responses, since dividing human CD4+ effector T cells can induce Foxp3 without attaining repressiv...

journal_title：Current opinion in immunology

authors： Tao R,de Zoeten EF,Ozkaynak E,Wang L,Li B,Greene MI,Wells AD,Hancock WW

更新日期：2007-10-01 00:00:00

abstract：:While mutations in human FOXP3 predispose individuals to autoimmune conditions, it is unclear how the mutant protein fails to function as a transcriptional regulator. There is also limited detail of how FOXP3 itself interacts with the transcriptional machinery and which components of the FOXP3 ensembles exert phenotyp...

journal_title：Current opinion in immunology

authors： Li B,Saouaf SJ,Samanta A,Shen Y,Hancock WW,Greene MI

更新日期：2007-10-01 00:00:00

abstract：:Our understanding of the X-linked lymphoproliferative syndrome (XLP) has advanced significantly in the past two years. The gene that is aberrant in the condition - SH2D1A/SAP, which encodes SAP (signaling lymphocytic activation molecule [SLAM]-associated protein) - was cloned, the crystal structure of its product was ...

journal_title：Current opinion in immunology

authors： Howie D,Sayos J,Terhorst C,Morra M

更新日期：2000-08-01 00:00:00

abstract：:Recent research has made great strides in uncovering the mechanisms by which the T helper 1 (Th1) cell gene expression program is established. In particular, studies examining the transcription factors T-bet, STAT1, and STAT4 have elucidated their roles in regulating Th1 signature genes, including Ifng, and have start...

journal_title：Current opinion in immunology

authors： Oestreich KJ,Weinmann AS

更新日期：2012-04-01 00:00:00

abstract：:Recent developments in the field of immune memory research and the accumulating literature on age-related alterations in homeostasis, primary and memory T cell responses make it pertinent to address whether and how memory responses are affected by aging with regard to their generation, maintenance, and protective func...

journal_title：Current opinion in immunology

authors： Nikolich-Zugich J,Rudd BD

更新日期：2010-08-01 00:00:00

abstract：:The rise in IgE-mediated food allergy in recent times is the likely result of gene-environment interactions mediated via epigenetic pathways. As epigenetic modifications, including DNA methylation, are at the interface between the environment and the genome, they may be ideal biomarkers of modifiable disease pathways....

journal_title：Current opinion in immunology

authors： Martino DJ,Saffery R,Allen KJ,Prescott SL

更新日期：2016-10-01 00:00:00

abstract：:Antigen presenting cells (APCs) alert the immune system to attack by extracellular organisms; APCs achieve this via internalization, degradation, and display of antigenic fragments on the cell surface by MHC class II molecules. These class II molecules bind to an accessory protein, termed the invariant chain, that ens...

journal_title：Current opinion in immunology

authors： Hiltbold EM,Roche PA

更新日期：2002-02-01 00:00:00

abstract：:The invariant chain (Ii) has been shown to play a critical role in the assembly, intracellular transport and function of MHC class II molecules. Recent studies suggest that these distinct activities can in many cases be attributed to distinct isoforms of Ii or to specific regions within it. Thus, regulation of Ii synt...

journal_title：Current opinion in immunology

authors： Sant AJ,Miller J

更新日期：1994-02-01 00:00:00

abstract：:Defensins are a component of the host response against bacterial infections. Multiple studies suggest a linked upregulation of beta-defensins and pro-inflammatory cytokines expression in various tissues, as well as the possibility of mutual induction. Recent data demonstrate the importance of nucleotide-binding oligom...

journal_title：Current opinion in immunology

authors： Menendez A,Brett Finlay B

更新日期：2007-08-01 00:00:00