Abstract：
:While mutations in human FOXP3 predispose individuals to autoimmune conditions, it is unclear how the mutant protein fails to function as a transcriptional regulator. There is also limited detail of how FOXP3 itself interacts with the transcriptional machinery and which components of the FOXP3 ensembles exert phenotypic changes to render cells able to mediate suppression. Increasing evidence indicates that the level and duration of FOXP3 expression plays a crucial role in the development and function of natural regulatory T cells (Tregs). Our studies focus on the post-translational modification of the FOXP3 protein, and how the FOXP3 complex ensemble, containing histone modification and chromatin-remodeling enzymes, defines its functional role in regulatory T cells. Understanding the molecular mechanisms underlying FOXP3 activity will provide therapeutic implications for transplantation, allergy, autoimmune disease and cancer.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Li B,Saouaf SJ,Samanta A,Shen Y,Hancock WW,Greene MIdoi
10.1016/j.coi.2007.07.006subject
Has Abstractpub_date
2007-10-01 00:00:00pages
583-8issue
5eissn
0952-7915issn
1879-0372pii
S0952-7915(07)00119-7journal_volume
19pub_type
杂志文章,评审abstract：:In normal hematopoiesis, differentiation and maturation of cell populations belonging to various lineages are tightly regulated by the interaction of many transcription factors. The relative numbers of different myeloid cells depends on their proliferative/apoptotic rate, while their identity relates to their recruitm...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.12.006
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abstract：:Lymphoid cell differentiation relies on precisely orchestrated gene activation and repression events. Gene targeting studies have demonstrated crucial roles for the transcription factors Ikaros and Aiolos in regulating multiple stages of B and T cell development. Recent experiments suggest that Ikaros and Aiolos set B...
journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(03)00101-8
更新日期：2003-10-01 00:00:00
abstract：:The field of Type 1 diabetes research has been quick to embrace the era of translational medicine in the recent epoch. Building upon some 30 years of intense immunological research, the past decade has been marked by a series of clinical trials designed to evaluate the potential beneficial effects of a range of immune...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2011.10.001
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abstract：:The adoptive transfer of T cells isolated or engineered to have specificity for diseased cells represents an ideal approach for the targeted therapy of human viral and malignant diseases. The therapeutic potential of adoptive T cell therapy for infections and cancer was demonstrated in rodent models long ago, but the ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2009.02.010
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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abstract：:While remarkable progress has been made using genetically altered mice to understand the importance of different cytokines in protecting against experimental infections or co-infections, an examination of the opportunistic infections that occur during HIV infection of humans does not yet show a clear picture of cytoki...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(00)00170-9
更新日期：2000-12-01 00:00:00
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journal_title：Current opinion in immunology
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更新日期：2012-10-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(05)80007-x
更新日期：1991-12-01 00:00:00
abstract：:Recent advances in the field of cellular therapy have focused on autologous T cells engineered to express a chimeric antigen receptor (CAR) against tumor antigens. Remarkable responses have been observed in patients receiving autologous CD19-redirected T cells for the treatment of B-lymphoid malignancies. However, the...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2018.03.013
更新日期：2018-04-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2016.09.004
更新日期：2016-12-01 00:00:00
abstract：:Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and con...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(98)80118-0
更新日期：1998-08-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(94)90034-5
更新日期：1994-02-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.11.003
更新日期：2008-02-01 00:00:00
abstract：:The discovery of novel immune receptors has led to a recent renaissance of research into the innate immune system, following decades of intense research of the adaptive immune system. Of particular interest has been the discovery of the natural killer (NK) cell receptors which, depending on type, interact with classic...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2007.08.002
更新日期：2007-10-01 00:00:00
abstract：:Phosphoinositide 3-kinase (PI3K) activation is essential for lymphocyte proliferation driven by receptors for antigen, costimulatory ligands and cytokines. The lipid products of PI3K contribute to the assembly of membrane-associated signaling complexes by promoting recruitment of selected proteins from the cytoplasm. ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2004.03.014
更新日期：2004-06-01 00:00:00
abstract：:Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of the HLA locus. Genetic polymorphisms in these genes have recently been associated with effects on HIV-1 pathogenesis. The history and implicati...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2008.05.007
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.12.013
更新日期：2011-04-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：1994-06-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2005.04.006
更新日期：2005-06-01 00:00:00
abstract：:T cell antigen receptor-induced signals are required for normal T cell development and function. Recent studies have investigated the mechanism(s) by which signals of different strengths are converted into distinct cellular fates during thymocyte development. These studies indicate the importance of the strength and d...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2003-04-01 00:00:00
abstract：:Our understanding of the X-linked lymphoproliferative syndrome (XLP) has advanced significantly in the past two years. The gene that is aberrant in the condition - SH2D1A/SAP, which encodes SAP (signaling lymphocytic activation molecule [SLAM]-associated protein) - was cloned, the crystal structure of its product was ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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更新日期：2000-08-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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abstract：:Vaccines have been developed and deployed against several important bacterial pathogens of humans, including Neisseria meningitidis, Bordetella pertussis, Streptococcus pneumoniae and Mycobacterium tuberculosis. These vaccines are generally considered a successful public health measure and are effective at controlling...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2015.04.002
更新日期：2015-10-01 00:00:00
abstract：:Cytokine receptor signaling plays an essential role in the early stages of lymphocyte development. Signals through various cytokine receptors - such as c-kit, flt3/flk2, CXCR4, the IL-7 receptor and the IL-15 receptor - are known to promote the expansion and survival of uncommitted progenitor cells as well as their mi...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(99)80027-2
更新日期：1999-04-01 00:00:00
