Abstract:
:The Toll-like receptors (TLRs) of the innate immune system detect host invasion by pathogens and initiate immune responses. All of the TLRs use the adaptor MyD88 to transduce a signal; however, two newly identified signaling molecules, TIRAP and TRIF, interact with a subset of the TLRs, suggesting a signaling specificity that may be relevant to the type of infection. Activation of the TRIF pathway, for example, leads to the production of antiviral gene products via the transcription factor, IRF3. In vivo experiments in TLR-deficient mice underscore the importance of TLRs in overcoming infection.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Kopp E,Medzhitov Rdoi
10.1016/s0952-7915(03)00080-3subject
Has Abstractpub_date
2003-08-01 00:00:00pages
396-401issue
4eissn
0952-7915issn
1879-0372pii
S0952791503000803journal_volume
15pub_type
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