Deciphering flavivirus-host interactions using quantitative proteomics.

abstract：:The treatment of autoimmune diseases using conventional chemical immunosuppressants has short-term effects, imposing the need for chronic treatment with its risks of over-immunosuppression. CD3-specific monoclonal antibodies can restore self-tolerance in a durable fashion after a single short-term treatment, as demons...

journal_title：Current opinion in immunology

authors： Chatenoud L

更新日期：2005-12-01 00:00:00

abstract：:While certain bacteria and respiratory viruses promote local inflammation and disease onset, a more diverse colonization of the different species in the (gut) microbiome may be linked to more regulatory responses and protection against asthma and allergies. These processes are also influenced in part by food intake, b...

journal_title：Current opinion in immunology

authors： Smits HH,van der Vlugt LE,von Mutius E,Hiemstra PS

更新日期：2016-10-01 00:00:00

abstract：:T cell antigen receptor-induced signals are required for normal T cell development and function. Recent studies have investigated the mechanism(s) by which signals of different strengths are converted into distinct cellular fates during thymocyte development. These studies indicate the importance of the strength and d...

journal_title：Current opinion in immunology

authors： Love PE,Chan AC

更新日期：2003-04-01 00:00:00

abstract：:A two chain model, composed of ligand-binding and signal transducing subunits, first identified in the interleukin-6 receptor system, has been revealed in several other cytokine systems. Common signal transducers shared by several receptor systems may explain a functional redundancy characteristic of cytokines. The si...

journal_title：Current opinion in immunology

authors： Akira S,Kishimoto T

更新日期：1992-06-01 00:00:00

abstract：:Diseases due to defect in tolerance induction such as allergy, celiac disease, or Type 1 Diabetes develop mostly in childhood indicating the necessity of early intervention for primary prevention. Epidemiological studies report that breastfeeding could protect from these diseases. However, data are controversial and t...

journal_title：Current opinion in immunology

authors： Verhasselt V

更新日期：2010-10-01 00:00:00

abstract：:Infection with helminths has been associated with lower rates of asthma and other allergic diseases. This has been attributed, in part, to the ability of helminths to induce regulatory T cells that suppress inappropriate immune responses to allergens. Recent compelling evidence suggests that helminths may promote regu...

journal_title：Current opinion in immunology

authors： Logan J,Navarro S,Loukas A,Giacomin P

更新日期：2018-10-01 00:00:00

abstract：:The past few years have seen significant growth in the number of known chemokines. Along with expansion in this field has come an appreciation of a role for chemokines beyond the chemotaxis of leukocytes. In particular, it appears that these molecules may represent major products of activated lymphocytes and that, in ...

journal_title：Current opinion in immunology

authors： Hedrick JA,Zlotnik A

更新日期：1996-06-01 00:00:00

abstract：:Mucosal vaccines may be used both to prevent mucosal infections through the activation of antimicrobial immunity and to treat systemic inflammatory diseases through the induction of antigen-specific mucosal tolerance. New, efficient mucosal adjuvants for human use have been designed based on, amongst others, bacterial...

journal_title：Current opinion in immunology

authors： Eriksson K,Holmgren J

更新日期：2002-10-01 00:00:00

abstract：:There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletio...

journal_title：Current opinion in immunology

authors： Pillai S,Mattoo H,Cariappa A

更新日期：2011-12-01 00:00:00

abstract：:Consolidating the information that we have on pharmacogenetics and on cytokine genetics to produce patient-oriented individualized drug regimens is an important challenge in transplantation medicine. Using a multi-variant approach based on genetic profile and other relevant clinical factors a score system may be devel...

journal_title：Current opinion in immunology

authors： Girnita DM,Burckart G,Zeevi A

更新日期：2008-10-01 00:00:00

abstract：:Immunotherapy of cancer through adoptive transfer of genetically engineered T-cells constitutes a more powerful strategy than attempts to mobilize the endogenous T-cell repertoire. Application of this technology in patients offers great opportunities towards a long-awaited breakthrough in cancer immunotherapy. However...

journal_title：Current opinion in immunology

authors： Offringa R

更新日期：2009-04-01 00:00:00

abstract：:The induction and execution of a successful anti-pathogen immune response requires a consecutive series of cellular interactions that begin in lymphoid environments and later extend into the periphery. Much of our current knowledge of these events has been gained using ex vivo approaches that yield important static in...

journal_title：Current opinion in immunology

authors： Mueller SN,Hickman HD

更新日期：2010-06-01 00:00:00

abstract：:Recent advances in the field of cellular therapy have focused on autologous T cells engineered to express a chimeric antigen receptor (CAR) against tumor antigens. Remarkable responses have been observed in patients receiving autologous CD19-redirected T cells for the treatment of B-lymphoid malignancies. However, the...

journal_title：Current opinion in immunology

authors： Daher M,Rezvani K

更新日期：2018-04-01 00:00:00

abstract：:The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first minutes or hours of exposure to an infectious challenge. The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as ...

journal_title：Current opinion in immunology

authors： Takahashi K,Ip WE,Michelow IC,Ezekowitz RA

更新日期：2006-02-01 00:00:00

abstract：:Initially, direct oncolysis was thought to be the sole mechanism through which oncolytic viruses (OVs) exert their anti-tumor effect, and the immune system was perceived as the major obstacle in oncolytic virotherapy. Over the last decade, there has been a lot of debate on whether the immune system is a friend or foe ...

journal_title：Current opinion in immunology

authors： Chaurasiya S,Chen NG,Fong Y

更新日期：2018-04-01 00:00:00

abstract：:The classification of T helper (T(H)) cells in subsets has progressively expanded and more effector subsets, besides T(H)1 and T(H)2, have been documented. These include follicular helper T cells (T(FH)), and the more recent T(H)17, 'T(H)9', and 'T(H)22'. In addition, T(H) are no longer thought of as terminally commit...

journal_title：Current opinion in immunology

authors： Veldhoen M

更新日期：2009-12-01 00:00:00

abstract：:Antigen presenting cells (APCs) alert the immune system to attack by extracellular organisms; APCs achieve this via internalization, degradation, and display of antigenic fragments on the cell surface by MHC class II molecules. These class II molecules bind to an accessory protein, termed the invariant chain, that ens...

journal_title：Current opinion in immunology

authors： Hiltbold EM,Roche PA

更新日期：2002-02-01 00:00:00

abstract：:The field of Type 1 diabetes research has been quick to embrace the era of translational medicine in the recent epoch. Building upon some 30 years of intense immunological research, the past decade has been marked by a series of clinical trials designed to evaluate the potential beneficial effects of a range of immune...

journal_title：Current opinion in immunology

authors： Roep BO,Peakman M

更新日期：2011-12-01 00:00:00

abstract：:CD8(+) T cells are key effector cells of the adaptive immune system, however their activity must be tightly regulated to allow pathogen clearance whilst preventing immunopathology and autoimmunity. In this review, we summarise the diversity of responses that CD8(+) T cells make to antigenic stimulation with a focus on...

journal_title：Current opinion in immunology

authors： Parish IA,Kaech SM

更新日期：2009-06-01 00:00:00

abstract：:Engagement of the TCR/CD3 complex triggers a cascade of events that result in T lymphocyte activation and promote positive and negative selection of thymocytes, T lymphocyte migration and effector functions, development and activation of regulatory T cells. Gene mutations that abrogate early TCR signaling are associat...

journal_title：Current opinion in immunology

authors： Notarangelo LD

更新日期：2014-12-01 00:00:00

abstract：:Successful vaccination relies on driving the immune response towards high specificity, affinity and longevity. Germinal centers facilitate the evolution of antigen-specific B cells by iterative rounds of diversification, selection, and differentiation to memory and plasma cells. Experimental evidence points to B cell ...

journal_title：Current opinion in immunology

authors： Dufaud CR,McHeyzer-Williams LJ,McHeyzer-Williams MG

更新日期：2017-04-01 00:00:00

abstract：:Recent evidence indicates that genes required for antigen processing are present in the class II region of the MHC. Two new classes of MHC genes that may encode much of the machinery required in the class I (endogenous) antigen-processing pathway have been discovered. There is evidence that genes required in the class...

journal_title：Current opinion in immunology

authors： Monaco JJ

更新日期：1992-02-01 00:00:00

abstract：:Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place sp...

journal_title：Current opinion in immunology

authors： Rubio-Ponce A,Hidalgo A,Ballesteros I

更新日期：2020-10-07 00:00:00

abstract：:While remarkable progress has been made using genetically altered mice to understand the importance of different cytokines in protecting against experimental infections or co-infections, an examination of the opportunistic infections that occur during HIV infection of humans does not yet show a clear picture of cytoki...

journal_title：Current opinion in immunology

authors： Mosier DE

更新日期：1994-08-01 00:00:00

abstract：:Macrophages specifically engulf apoptotic cells but not healthy cells. Phosphatidylserine (PtdSer) is localized at the inner leaflet of plasma membranes as a result of the action of flippases (ATP11A and 11C). When cells undergo apoptosis, caspase 3 cleaves and inactivates the flippases, while simultaneously cleaving ...

journal_title：Current opinion in immunology

authors： Nagata S,Segawa K

更新日期：2020-08-24 00:00:00

abstract：:Antimicrobials represent a broad class of chemicals with the intended purpose of eliminating or controlling the growth of harmful microorganisms. Exposure can occur occupationally or through the use or consumption of consumer products. The use of antimicrobial agents has been associated with an increased incidence of ...

journal_title：Current opinion in immunology

authors： Anderson SE,Weatherly L,Shane HL

更新日期：2019-10-01 00:00:00

abstract：:Tolerance to the foetal 'allograft' has been extensively studied in the past few years, providing interesting new insights. In addition to a potential role for HLA-G, which has been widely discussed, there are hypotheses suggesting roles for several other molecules or cells: leukemia inhibitory factor and its receptor...

journal_title：Current opinion in immunology

authors： Thellin O,Coumans B,Zorzi W,Igout A,Heinen E

更新日期：2000-12-01 00:00:00

abstract：:Thymocytes co-expressing the CD4 and CD8 co-receptors differentiate into mature T cells that express either CD4 or CD8 and have helper or cytotoxic functions, respectively. Recent studies indicate that commitment to the CD4+ or CD8+ lineages occurs stochastically, but retention of the appropriate co-receptor is requir...

journal_title：Current opinion in immunology

authors： Davis CB,Littman DR

更新日期：1994-04-01 00:00:00

abstract：:Cytokine receptor signaling plays an essential role in the early stages of lymphocyte development. Signals through various cytokine receptors - such as c-kit, flt3/flk2, CXCR4, the IL-7 receptor and the IL-15 receptor - are known to promote the expansion and survival of uncommitted progenitor cells as well as their mi...

journal_title：Current opinion in immunology

authors： Baird AM,Gerstein RM,Berg LJ

更新日期：1999-04-01 00:00:00

abstract：:Most viral vaccines provide protection from infection through the generation of neutralizing antibodies (nAbs). The repertoire of B cells responding to immunization is the starting material from which nAbs eventually arise. Immunization strategies are increasingly targeting precise B cell specificities to mimic nAbs g...

journal_title：Current opinion in immunology

authors： Havenar-Daughton C,Abbott RK,Schief WR,Crotty S

更新日期：2018-08-01 00:00:00