Abstract：
:Deep brain stimulation (DBS) has evolved into a powerful clinical therapy for a range of neurological disorders, but even with impressive clinical growth, DBS technology has been relatively stagnant over its history. However, enhanced collaborations between neural engineers, neuroscientists, physicists, neurologists, and neurosurgeons are beginning to address some of the limitations of current DBS technology. These interactions have helped to develop novel ideas for the next generation of clinical DBS systems. This review attempts collate some of that progress with two goals in mind. First, provide a general description of current clinical DBS practices, geared toward educating biomedical engineers and computer scientists on a field that needs their expertise and attention. Second, describe some of the technological developments that are currently underway in surgical targeting, stimulation parameter selection, stimulation protocols, and stimulation hardware that are being directly evaluated for near term clinical application.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
McIntyre CC,Chaturvedi A,Shamir RR,Lempka SFdoi
10.1016/j.brs.2014.07.039subject
Has Abstractpub_date
2015-01-01 00:00:00pages
21-6issue
1eissn
1935-861Xissn
1876-4754pii
S1935-861X(14)00268-Xjournal_volume
8pub_type
杂志文章,评审abstract：BACKGROUND:Deep brain stimulation of the ventro-intermedius nucleus of the thalamus is an established treatment for tremor of differing etiologies but factors that may predict the short- and especially long-term outcome of surgery are still largely unknown. METHODS:We retrospectively investigated the clinical, pharmac...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.12.014
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) has been used for neuropsychiatric disorders in clinical and research settings for almost 50 years now. Recent evidence demonstrates some efficacy in treating obsessive-compulsive disorder and major depression in patients refractory to other treatment modalities beyond single cas...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.03.002
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Recent evidence suggests that transcranial direct current stimulation (tDCS) may interact with the dopaminergic system to affect cognitive flexibility. Objective/hypotheses: We examined whether putative reduction of dopamine levels through the acute phenylalanine/tyrosine depletion (APTD) procedure and excit...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2019.08.016
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:the use of combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) for the functional evaluation of the cerebral cortex in health and disease is becoming increasingly common. However, there is still some ambiguity regarding the extent to which brain responses to auditory and somatos...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.10.011
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Pairing sensory or motor events with vagus nerve stimulation (VNS) can reorganize sensory or motor cortex. Repeatedly pairing a tone with a brief period of VNS increases the proportion of primary auditory cortex (A1) responding to the frequency of the paired tone. However, the relationship between VNS intens...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.08.018
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Abdominal bilateral vagal stimulation reduces food intake in animals. However, the classical square wave, mA range current generator is poorly effective to evoke action potentials on A∂ and C neurons that represent the majority of vagal neurons at the abdominal level. OBJECTIVE/HYPOTHESIS:METHODS: The curre...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.04.126
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Transcranial alternating current stimulation (tACS) has been shown to modulate auditory, visual, cognitive and motor function. However, tACS effects can often be small and difficult to reproduce. Thus, the establishment of robust experimental and analysis procedures is of high importance. We reviewed the ana...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.03.011
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) has emerged as a potential therapeutic strategy in the treatment of neurological disorders including epilepsy. However, the cellular mechanism responsible for the effects of DBS remains largely undefined. Therefore, using electrophysiological approach, we aimed to determine the a...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.11.001
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Although some studies have reported significant reductions in food cravings following the single-session of repetitive transcranial magnetic stimulation (rTMS), there is little research on the effects of multi-session of rTMS on food consumption and body weight in obese subjects. OBJECTIVE:We conducted 4-we...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2019.07.020
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Low-level light therapy (LLLT) with transcranial laser is a non-invasive form of neuroenhancement shown to regulate neuronal metabolism and cognition. Attention bias modification (ABM) is a cognitive intervention designed to improve depression by decreasing negative attentional bias, but to date its efficacy...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2016.05.009
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Although a significant subset of patients with major depressive disorder (MDD) fail to respond to medical or behavioural therapy, deep brain stimulation (DBS) applied to the subgenual cingulate cortex (SCC; sg25) has been shown to reduce depressive symptoms in a subset of patients. This area receives project...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2016.11.013
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Dopaminergic activity within the dorsolateral prefrontal cortex (dlPFC) has been implicated in the control of cognitive flexibility. Much of the evidence for a causative relationship between cognitive flexibility and dopamine has come from animal studies, whilst human data have largely been correlational. O...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2018.12.001
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Dopamine agonist therapy and deep brain stimulation (DBS) of the subthalamic nucleus (STN) are antiparkinsonian treatments that act on a different part of the basal ganglia-thalamocortical motor circuitry, yet produce similar symptomatic improvements. OBJECTIVE/HYPOTHESIS:The purpose of this study was to id...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2011.09.002
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) has been used to improve exercise performance, though the protocols used, and results found are mixed. OBJECTIVE:We aimed to analyze the effect of tDCS on improving exercise performance. METHODS:A systematic search was performed on the following databases, unt...
journal_title：Brain stimulation
pub_type： 杂志文章,meta分析
doi：10.1016/j.brs.2018.12.227
更新日期：2019-01-01 00:00:00
abstract：:Inhibitory control mechanisms are important in a range of behaviours to prevent execution of motor acts which, having been planned, are no longer necessary or appropriate. Examples of this can be seen in a range of sports, such as cricket and baseball, where the choice between execution and inhibition of a bat swing m...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.03.012
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:White matter hyperintensities (WMH) are estimated to occur in greater than 63% of older adults over the age of 60 years. WMH identified in the T2-weighted FLAIR images can be combined with T1-weighted images to enhance individualized current flow models of older adults by accounting for the presence of WMH a...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.11.009
更新日期：2021-01-01 00:00:00
abstract：:Right unilateral ultra-brief electroconvulsive therapy (RUL UB ECT) has been shown to be efficacious with minimal cognitive adverse effects in adult patients with major depression. We present the case of a 14-year-old girl with major depressive disorder with catatonic and psychotic features whose symptoms remitted aft...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2009.07.003
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Although cervical vagus nerve stimulation is effective for reducing infarct volume in rats, it is not feasible for acute human stroke as it requires surgical incision of the neck. We hypothesized that stimulation of the dermatome in the external ear innervated by the vagus nerve (auricular vagus nerve stimul...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.09.009
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Non-invasive direct current stimulation (DCS) of the brain induces functional plasticity in vitro and facilitates motor learning across species. The effect of DCS on structural synaptic plasticity is currently unknown. OBJECTIVE:This study addresses the effects and the underlying mechanisms of anodal DCS on...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.07.026
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Temporal lobe epilepsy (TLE) is often associated with memory deficits. Given the putative role for sleep spindles memory consolidation, spindle generators skewed toward the affected lobe in TLE subjects may be a neurophysiological marker of defective memory. Slow-oscillatory transcranial direct current stimu...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2015.01.410
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Vagus nerve stimulation (VNS) significantly reduces infarct volume in rat models of cerebral ischemia, but the mechanism of this protective effect remains open. HYPOTHESIS:This study tested the hypothesis that non-invasive VNS (nVNS), during transient middle cerebral artery occlusion (MCAO), protects the bl...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.01.034
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:There is much interest in whether daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) over several weeks may become a clinically useful antidepressant treatment. Although rTMS appears largely safe, many patients report that this procedure is somewhat painful, which may restrict its ulti...
journal_title：Brain stimulation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.brs.2008.09.001
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:There has been an explosion of interest in methods of exogenous brain stimulation that induce changes in the excitability of human cerebral cortex. The expectation is that these methods may promote recovery of function following brain injury. To assess their effects on motor output, it is typical to assess t...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2013.01.016
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Although pallidal deep brain stimulation (GPi-DBS) is an effective treatment for dystonia, it may cause important stimulation-induced side-effects such as hypokinetic dysarthria or stuttering. However, the reasons behind the occurrence of these side-effects remain unknown. OBJECTIVE:To objectively investiga...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.03.007
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Directional Deep Brain Stimulation (D-DBS) allows axially asymmetric electrical field shaping, away from structures causing side-effects. However, concerns regarding the impact on device lifespan and complexity of the monopolar survey have contributed to sparing use of these features. OBJECTIVE:To investiga...
journal_title：Brain stimulation
pub_type： 临床试验,杂志文章
doi：10.1016/j.brs.2017.12.015
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Dual-site transcranial magnetic stimulation (ds-TMS) is a neurophysiological technique to measure functional connectivity between cortical areas. OBJECTIVE/HYPOTHESIS:To date, no study has used ds-TMS to investigate short intra-hemispheric interactions between the somatosensory areas and primary motor corte...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.04.009
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Task switching, defined as the ability to flexibly switch between tasks in the face of goal shifting, is a central mechanism in cognitive control. Task switching is thought to involve both prefrontal cortex (PFC) and parietal regions. Our previous work has shown that it is possible to modulate set shifting t...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.10.006
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. Thi...
journal_title：Brain stimulation
pub_type： 信件
doi：10.1016/j.brs.2017.05.002
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown promise as a treatment for refractory auditory hallucinations (AH) in Schizophrenia. Most previous studies have examined the effect of low frequency, left-sided stimulation (LFL) (1 Hz) to the temporoparietal cortex (TPC). Priming stimulation (6 H...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2011.12.002
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Direct stimulation of the vagus nerve in the neck via surgically implanted electrodes is protective in animal models of stroke. We sought to determine the safety and efficacy of a non-invasive cervical VNS (nVNS) method using surface electrodes applied to the skin overlying the vagus nerve in the neck in a m...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.11.008
更新日期：2016-03-01 00:00:00
