Abstract:
BACKGROUND:Temporal lobe epilepsy (TLE) is often associated with memory deficits. Given the putative role for sleep spindles memory consolidation, spindle generators skewed toward the affected lobe in TLE subjects may be a neurophysiological marker of defective memory. Slow-oscillatory transcranial direct current stimulation (sotDCS) during slow waves sleep (SWS) has previously been shown to enhance sleep-dependent memory consolidation by increasing slow-wave sleep and modulating sleep spindles. OBJECTIVE/HYPOTHESIS:To test if anodal sotDCS over the affected TL prior to a nap affects sleep spindles and whether this improves memory consolidation. METHODS:Randomized controlled cross-over study. 12 people with TLE underwent sotDCS (0.75 Hz; 0-250 μV, 30 min) or sham before daytime nap. Declarative verbal and visuospatial learning were tested. Fast and slow spindle signals were recorded by 256-channel EEG during sleep. In both study arms, electrical source imaging (ESI) localized cortical generators. Neuropsychological data were analyzed with general linear model statistics or the Kruskal-Wallis test (P or Z < 0.05), and neurophysiological data tested with the Mann-Whitney t test and binomial distribution test (P or Z < 0.05). RESULTS:An improvement in declarative (P = 0.05) and visuospatial memory performance (P = 0.048) emerged after sotDCS. SotDCS increased slow spindle generators current density (Z = 0.001), with a shift to the anterior cortical areas. CONCLUSIONS:Anodal sotDCS over the affected temporal lobe improves declarative and visuospatial memory performance by modulating slow sleep spindles cortical source generators. SotDCS appears a promising tool for memory rehabilitation in people with TLE.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Del Felice A,Magalini A,Masiero Sdoi
10.1016/j.brs.2015.01.410subject
Has Abstractpub_date
2015-05-01 00:00:00pages
567-73issue
3eissn
1935-861Xissn
1876-4754pii
S1935-861X(15)00874-8journal_volume
8pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Theories of executive control propose that communication between medial frontal cortex (MFC) and lateral prefrontal cortex (lPFC) is critical for learning. 6-Hz phase synchronization may be the mechanism by which neural activity between MFC and lPFC is coordinated into a functional network. Recent evidence s...
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pub_type: 信件
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
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更新日期:2013-07-01 00:00:00
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journal_title:Brain stimulation
pub_type: 信件
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更新日期:2019-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
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更新日期:2014-09-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2013.11.002
更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.brs.2012.11.001
更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-07-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2011.09.002
更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.brs.2019.06.021
更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.brs.2017.04.126
更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.brs.2020.04.017
更新日期:2020-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.11.002
更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.05.013
更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,评审
doi:10.1016/j.brs.2015.01.001
更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.12.224
更新日期:2019-01-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1016/j.brs.2014.05.003
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.brs.2017.11.005
更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.08.018
更新日期:2016-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2019.07.020
更新日期:2019-01-01 00:00:00