Abstract:
BACKGROUND:Abdominal bilateral vagal stimulation reduces food intake in animals. However, the classical square wave, mA range current generator is poorly effective to evoke action potentials on A∂ and C neurons that represent the majority of vagal neurons at the abdominal level. OBJECTIVE/HYPOTHESIS:METHODS: The current thresholds for pulsons (S2 & S3) and millisecond pulses (S1) required to trigger action potentials were calculated in 5 anaesthetized pigs using single fibre recording. Similar stimulation protocols were compared chronically to sham stimulation in 24 pigs. After two weeks of chronic stimulation, food intake and brain metabolism were investigated. The electrical characteristics and histology of the vagus nerve were also studied. RESULTS:S3 stimulation required a lower amount of charges to trigger an action potential. Chronically applied S2 & S3 activated the dorsal vagal complex and increased the metabolism of its afferent cortical structures. They also reduced energy intake together with a reduced ingestion of high fat and high sugar diets. All these effects were not observed for the S1 group. The vagal histology for the S1, S2 and S3 groups was not different from that of the sham. CONCLUSIONS:These findings demonstrate that pulsons applied bilaterally on the abdominal vagus reduced food intake as a consequence of the activation of the brainstem and higher-order brain areas.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Malbert CH,Bobillier E,Picq C,Divoux JL,Guiraud D,Henry Cdoi
10.1016/j.brs.2017.04.126subject
Has Abstractpub_date
2017-01-01 00:00:00pages
735-743issue
4eissn
1935-861Xissn
1876-4754pii
S1935-861X(17)30787-8journal_volume
10pub_type
杂志文章abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. O...
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journal_title:Brain stimulation
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Brain stimulation
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
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journal_title:Brain stimulation
pub_type: 杂志文章
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journal_title:Brain stimulation
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.09.009
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pub_type: 杂志文章
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journal_title:Brain stimulation
pub_type: 杂志文章,评审
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journal_title:Brain stimulation
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.01.004
更新日期:2015-05-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.04.011
更新日期:2020-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2016.05.009
更新日期:2016-09-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,评审
doi:10.1016/j.brs.2014.07.039
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Vagus nerve stimulation (VNS) is indicated for treatment-resistant epilepsy and depression. Electrophysiologic recordings in the rat brain have shown that VNS promptly increases the firing rate of NE neurons and subsequently that of 5-HT neurons. Thus far, it appears that the standard stimulation parameters ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2011.04.005
更新日期:2012-07-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
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更新日期:2014-09-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2014.11.019
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that primary motor cortex (M1) excitability is modulated by motor skill learning and that the M1 plays a crucial role in motor memory. However, the following questions remain: (1) At what stage do changes in M1 excitability occur? (2) Are learning-induced changes in leg M1 excitab...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.07.025
更新日期:2015-11-01 00:00:00