Abstract:
BACKGROUND:Vagus nerve stimulation (VNS) significantly reduces infarct volume in rat models of cerebral ischemia, but the mechanism of this protective effect remains open. HYPOTHESIS:This study tested the hypothesis that non-invasive VNS (nVNS), during transient middle cerebral artery occlusion (MCAO), protects the blood-brain barrier (BBB), leading to reduced infarct size in ischemic brain. METHODS:Spontaneous hypertensive rats (SHRs) were subjected to a 90 min MCAO. nVNS treated rats received 5 stimulations (duration: 2 min; every 10 min) on the skin overlying the cervical vagus nerve in the neck beginning 30 min after MCAO onset. Control rats received the same stimulations on the quadriceps femoris muscle. Twenty-four hours after MCAO onset, MRI and immunohistochemistry (IHC) were performed for analyses of infarct size and BBB leakage. RESULTS:Compared with the control group, anatomic MRI T2-weighted images showed significantly smaller infarct sizes in the nVNS group. Dynamic contrast-enhanced (DCE)-MRI showed a significantly decreased BBB transfer rate (Ki map) in the lesion area in the nVNS group, which was spatially correlated with the attenuation of the infarct size. Furthermore, significantly lower serum IgG leakage, visualized by IHC, was seen in the ischemic hemisphere in nVNS treated rats. nVNS also protected vascular tight junction proteins from disruption in microvessels, and reduced expression of matrix metalloproteinases-2/9 in reactive astrocytes surrounding the compromised vessels in the ischemic hemispheres. CONCLUSION:Our data suggest that the neuroprotective role of a series of nVNS administrations during MCA occlusion, spatially correlates with protection of BBB integrity from damage and reduction of infarct extent induced by ischemic stroke.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Yang Y,Yang LY,Orban L,Cuylear D,Thompson J,Simon B,Yang Ydoi
10.1016/j.brs.2018.01.034subject
Has Abstractpub_date
2018-01-01 00:00:00pages
689-698issue
4eissn
1935-861Xissn
1876-4754pii
S1935-861X(18)30064-0journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Although some studies have reported significant reductions in food cravings following the single-session of repetitive transcranial magnetic stimulation (rTMS), there is little research on the effects of multi-session of rTMS on food consumption and body weight in obese subjects. OBJECTIVE:We conducted 4-we...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2019.07.020
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Balance problems contribute to reduced quality of life in Parkinson's disease (PD) and available treatments are often insufficient for treating axial and postural motor symptoms. OBJECTIVE:To investigate the safety of use and possible effects of stochastic vestibular stimulation (SVS) alone and combined wit...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2014.11.019
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Recently, navigated transcranial magnetic stimulation (nTMS) has been suggested to be useful in preoperative functional localization of motor cortex in patients having tumors close to the somatomotor cortex. Resection of tumors in anatomically predicted eloquent areas without adverse effects have emphasized ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.04.012
更新日期:2013-05-01 00:00:00
abstract::Right unilateral ultra-brief electroconvulsive therapy (RUL UB ECT) has been shown to be efficacious with minimal cognitive adverse effects in adult patients with major depression. We present the case of a 14-year-old girl with major depressive disorder with catatonic and psychotic features whose symptoms remitted aft...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2009.07.003
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Neuroimaging studies suggest that facial expression recognition is processed in the bilateral posterior superior temporal sulcus (pSTS). Our recent repetitive transcranial magnetic stimulation (rTMS) study demonstrates that the bilateral pSTS is causally involved in expression recognition, although involveme...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.04.011
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) was recently shown to promote recovery of voluntary signs of consciousness in some patients in minimally conscious state (MCS). However, it remains unclear why clinical improvement is only observed in a subgroup of patients. OBJECTIVES:In this retrospective stu...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2015.07.024
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Noninvasive brain stimulation is a powerful way to modify excitability of the cerebral cortex in humans and is increasingly used to treat psychiatric disorders. The observed clinical effects are in the moderate range and it has been suggested that the efficiency of brain stimulation depends on the underlying...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2010.07.002
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) has been used to improve exercise performance, though the protocols used, and results found are mixed. OBJECTIVE:We aimed to analyze the effect of tDCS on improving exercise performance. METHODS:A systematic search was performed on the following databases, unt...
journal_title:Brain stimulation
pub_type: 杂志文章,meta分析
doi:10.1016/j.brs.2018.12.227
更新日期:2019-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.03.012
更新日期:2012-04-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.06.005
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Current density is considered an important factor in determining the outcomes of tDCS, and is determined by the current intensity and electrode size. Previous studies examining the effect of these parameters on motor cortical excitability with small sample sizes reported mixed results. OBJECTIVE/HYPOTHESIS:...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.08.003
更新日期:2016-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.01.002
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:A session of motor skill learning is accompanied by transient increases in corticospinal excitability(CSE), which are thought to reflect acute changes in neuronal connectivity associated with improvements in sensorimotor performance. Factors influencing changes in excitability and motor skill with continued ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.11.005
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation therapy in epilepsy with conflicting results in terms of efficacy and safety. OBJECTIVE:Review the literature about the efficacy and safety of tDCS in epilepsy in humans and animals. METHODS:We searched studies in Pu...
journal_title:Brain stimulation
pub_type: 杂志文章,评审
doi:10.1016/j.brs.2015.01.001
更新日期:2015-05-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,多中心研究
doi:10.1016/j.brs.2020.02.020
更新日期:2020-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.02.008
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to induce changes in cortical neural excitability. This report presents findings from the first participant of a safety and efficacy study that examined a therapeutic rTMS protocol for persons with severe traumatic brain injury (TBI)...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2008.09.004
更新日期:2009-01-01 00:00:00
abstract::The human motor cortex can be activated by transcranial magnetic stimulation (TMS) evoking a high-frequency repetitive discharge of corticospinal neurones. The exact physiologic mechanisms producing the corticospinal activity still remain unclear because of the complexity of the interactions between the currents induc...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2011.07.008
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Non-invasive direct current stimulation (DCS) of the brain induces functional plasticity in vitro and facilitates motor learning across species. The effect of DCS on structural synaptic plasticity is currently unknown. OBJECTIVE:This study addresses the effects and the underlying mechanisms of anodal DCS on...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.07.026
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown promise as a treatment for refractory auditory hallucinations (AH) in Schizophrenia. Most previous studies have examined the effect of low frequency, left-sided stimulation (LFL) (1 Hz) to the temporoparietal cortex (TPC). Priming stimulation (6 H...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
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更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Transcranial magnetic stimulation (TMS) is a noninvasive neuromodulation technique with therapeutic applications for the treatment of major depressive disorder (MDD). The standard protocol uses high frequency stimulation over the left dorsolateral prefrontal cortex (DLPFC) identified in a heuristic manner le...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.10.004
更新日期:2019-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.01.056
更新日期:2014-05-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2015.01.415
更新日期:2015-07-01 00:00:00
abstract::Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the surgical therapy of choice for medically intractable Parkinson's disease. However, quantitative understanding of the interaction between the electric field generated by DBS and the underlying neural tissue is limited. Recently, computational ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2010.01.003
更新日期:2010-04-01 00:00:00
abstract::Deep brain stimulation (DBS) has evolved into a powerful clinical therapy for a range of neurological disorders, but even with impressive clinical growth, DBS technology has been relatively stagnant over its history. However, enhanced collaborations between neural engineers, neuroscientists, physicists, neurologists, ...
journal_title:Brain stimulation
pub_type: 杂志文章,评审
doi:10.1016/j.brs.2014.07.039
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is considered as an effective treatment for adults with major depressive disorder. However, it remains unknown whether rTMS has comparable or better efficacy in adolescents. OBJECTIVE:The current naturalistic study aimed to investigate the efficacy and cli...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.09.007
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that primary motor cortex (M1) excitability is modulated by motor skill learning and that the M1 plays a crucial role in motor memory. However, the following questions remain: (1) At what stage do changes in M1 excitability occur? (2) Are learning-induced changes in leg M1 excitab...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.07.025
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Task switching, defined as the ability to flexibly switch between tasks in the face of goal shifting, is a central mechanism in cognitive control. Task switching is thought to involve both prefrontal cortex (PFC) and parietal regions. Our previous work has shown that it is possible to modulate set shifting t...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.10.006
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:A prime objective driving the recent development of human neural prosthetics is to stimulate neural circuits in a manner time-locked to ongoing brain activity. The human supplementary motor area (SMA) is a particularly useful target for this objective because it displays characteristic neural activity just p...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.03.003
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Dopamine agonist therapy and deep brain stimulation (DBS) of the subthalamic nucleus (STN) are antiparkinsonian treatments that act on a different part of the basal ganglia-thalamocortical motor circuitry, yet produce similar symptomatic improvements. OBJECTIVE/HYPOTHESIS:The purpose of this study was to id...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2011.09.002
更新日期:2012-10-01 00:00:00