Abstract：
BACKGROUND:White matter hyperintensities (WMH) are estimated to occur in greater than 63% of older adults over the age of 60 years. WMH identified in the T2-weighted FLAIR images can be combined with T1-weighted images to enhance individualized current flow models of older adults by accounting for the presence of WMH and its effects on delivered tES current in the aging brain. METHODS:Individualized head models were derived from T1-weighted images of 130 healthy older adults (mean = 71 years). Lesions segmented from FLAIR acquisition were added to individualized models. Current densities were computed in the brain and compared between models with and without lesions. MAIN RESULTS:Integrating WMH into the models resulted in an overall decrease (up to 7%) in median current densities in the brain outside lesion regions. Changes in current density and total lesion volume was positively correlated (R2 = 0.31, p < 0.0001). CONCLUSIONS:Incorporating WMH into individualized models may increase the accuracy of predicted tES current flow in the aging brain.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Indahlastari A,Albizu A,Boutzoukas EM,O'Shea A,Woods AJdoi
10.1016/j.brs.2020.11.009subject
Has Abstractpub_date
2021-01-01 00:00:00pages
69-73issue
1eissn
1935-861Xissn
1876-4754pii
S1935-861X(20)30296-5journal_volume
14pub_type
杂志文章abstract：BACKGROUND:The final common pathway in tinnitus generation is considered to be synchronized auditory oscillatory hyperactivity. Intracranial auditory cortex stimulation (iACS) via implanted electrodes has been developed to treat severe cases of intractable tinnitus targeting this final common pathway, in the hope of be...
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更新日期：2015-05-01 00:00:00
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更新日期：2015-11-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2019-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.brs.2010.03.002
更新日期：2011-01-01 00:00:00
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更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
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更新日期：2019-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-09-01 00:00:00
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更新日期：2020-01-01 00:00:00
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更新日期：2015-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.brs.2017.01.007
更新日期：2017-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2018-01-01 00:00:00
