Abstract：
BACKGROUND:Pairing sensory or motor events with vagus nerve stimulation (VNS) can reorganize sensory or motor cortex. Repeatedly pairing a tone with a brief period of VNS increases the proportion of primary auditory cortex (A1) responding to the frequency of the paired tone. However, the relationship between VNS intensity and cortical map plasticity is not known. OBJECTIVE/HYPOTHESIS:The primary goal of this study was to determine the range of VNS intensities that can be used to direct cortical map plasticity. METHODS:The rats were exposed to a 9 kHz tone paired with VNS at intensities of 0.4, 0.8, 1.2, or 1.6 mA. RESULTS:In rats that received moderate (0.4-0.8 mA) intensity VNS, 75% more cortical neurons were tuned to frequencies near the paired tone frequency. A two-fold effective range is broader than expected based on previous VNS studies. Rats that received high (1.2-1.6 mA) intensity VNS had significantly fewer neurons tuned to the same frequency range compared to the moderate intensity group. CONCLUSION:This result is consistent with previous results documenting that VNS is memory enhancing as a non-monotonic relationship of VNS intensity.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Borland MS,Vrana WA,Moreno NA,Fogarty EA,Buell EP,Sharma P,Engineer CT,Kilgard MPdoi
10.1016/j.brs.2015.08.018subject
Has Abstractpub_date
2016-01-01 00:00:00pages
117-23issue
1eissn
1935-861Xissn
1876-4754pii
S1935-861X(15)01125-0journal_volume
9pub_type
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