Abstract：
BACKGROUND:Studies have found that pairing vagus nerve stimulation (VNS) with motor activity accelerates cortical reorganization. This synchronous pairing may enhance motor recovery. OBJECTIVE:To develop and validate a motor-activated auricular vagus nerve stimulation (MAAVNS) system as a potential neurorehabilitation tool. METHODS:We created MAAVNS and validated its function as part of an ongoing clinical trial investigating whether taVNS-paired rehabilitation enhances oromotor learning. We compared 3 different MAAVNS EMG electrode configurations in 3 neonates. The active lead was placed over the buccinator muscle. Reference lead placements were orbital, temporal or frontal. RESULTS:The frontal reference lead produced the highest sensitivity (0.87 ± 0.07 (n = 8)) and specificity (0.64 ± 0.13 (n = 8)). Oral sucking reliably triggers MAAVNS stimulation with high confidence. CONCLUSION:EMG electrodes placed on target orofacial muscles can effectively trigger taVNS stimuli in infants in a closed loop fashion.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Cook DN,Thompson S,Stomberg-Firestein S,Bikson M,George MS,Jenkins DD,Badran BWdoi
10.1016/j.brs.2020.02.028subject
Has Abstractpub_date
2020-01-01 00:00:00pages
800-803issue
3eissn
1935-861Xissn
1876-4754pii
S1935-861X(20)30050-4journal_volume
13pub_type
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