Abstract：
BACKGROUND:Task switching, defined as the ability to flexibly switch between tasks in the face of goal shifting, is a central mechanism in cognitive control. Task switching is thought to involve both prefrontal cortex (PFC) and parietal regions. Our previous work has shown that it is possible to modulate set shifting tasks using 1 mA tDCS on both the left dorsolateral prefrontal cortex and the left primary motor area. However, it remains unclear whether the effects of PFC tDCS on task switching are hemisphere-dependent. OBJECTIVES:We aimed to test the effects of three types of cross-hemispheric tDCS over the PFC (left anode-right cathode [LA-RC], left cathode-right anode [LC-RA] and sham stimulation) on participants' performance (reaction time) and accuracy (correct responses) in two task-switching paradigms (i.e., letter/digit naming and vowel-consonant/parity tasks). METHODS:Sixteen participants received cross-hemispheric tDCS over the PFC in two task-switching paradigms. RESULTS:The results show that cross-hemispheric tDCS over the PFC modulates task-switching ability in both paradigms. Our results were task and hemisphere-specific, such that in the letter/digit naming task, LA-RC tDCS increased switching performance, whereas LC-RA tDCS improved accuracy. On the other hand, in the vowel-consonant/parity task, LA-RC improved accuracy, and decreased switching performance. CONCLUSIONS:Our findings confirm the notion that involvement of the PFC on task switching depends critically on laterality, implying the existence of different roles for the left hemisphere and the right hemisphere in task switching.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Leite J,Carvalho S,Fregni F,Boggio PS,Gonçalves OFdoi
10.1016/j.brs.2012.10.006subject
Has Abstractpub_date
2013-07-01 00:00:00pages
660-7issue
4eissn
1935-861Xissn
1876-4754pii
S1935-861X(12)00198-2journal_volume
6pub_type
杂志文章abstract：BACKGROUND:No consensus exists in the clinical transcranial magnetic stimulation (TMS) field as to the best method for targeting the left dorsolateral prefrontal cortex (DLPFC) for depression treatment. Two common targeting methods are the Beam F3 method and the 5.5 cm rule. OBJECTIVE:Evaluate the anatomical reliabili...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.01.010
更新日期：2020-01-01 00:00:00
abstract：:The intensity of sound emanating from the discharge of magnetic coils used in repetitive transcranial magnetic stimulation (rTMS) can potentially cause acoustic trauma. Per Occupational Safety and Health Administration (OSHA) standards for safety of noise exposure, hearing protection is recommended beyond restricted l...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.01.056
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Pairing sensory or motor events with vagus nerve stimulation (VNS) can reorganize sensory or motor cortex. Repeatedly pairing a tone with a brief period of VNS increases the proportion of primary auditory cortex (A1) responding to the frequency of the paired tone. However, the relationship between VNS intens...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.08.018
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Chronic severe tinnitus can be greatly detrimental to quality of life. Some authors have reported benefit of repetitive transcranial magnetic stimulation, others of electrical cortical stimulation by stimulating the Heschl's gyrus or secondary auditory areas. OBJECTIVE:To evaluate the efficacy of chronic el...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2014.05.008
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Temporal lobe epilepsy (TLE) is often associated with memory deficits. Given the putative role for sleep spindles memory consolidation, spindle generators skewed toward the affected lobe in TLE subjects may be a neurophysiological marker of defective memory. Slow-oscillatory transcranial direct current stimu...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2015.01.410
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Traditional transcranial magnetic stimulation mapping involves systematically delivering stimuli over a predefined grid. The pseudorandom walk method seeks to improve map acquisition times by abandoning the grid in favour of delivering stimuli randomly over a given area. OBJECTIVES:To i) determine the minim...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.07.043
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Transcutaneous vagus nerve stimulation (tVNS) is a new, non-invasive technique being investigated as an intervention for a variety of clinical disorders, including epilepsy and depression. It is thought to exert its therapeutic effect by increasing central norepinephrine (NE) activity, but the evidence suppo...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.12.224
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Dopaminergic activity within the dorsolateral prefrontal cortex (dlPFC) has been implicated in the control of cognitive flexibility. Much of the evidence for a causative relationship between cognitive flexibility and dopamine has come from animal studies, whilst human data have largely been correlational. O...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2018.12.001
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Animal models of Parkinson's Disease (PD) demonstrated increased facilitatory cortico-striatal activity, reflecting overactive glutamatergic neurotransmission and contributing to the pathophysiology of l-dopa induced dyskinesias (LIDs). OBJECTIVE:To assess different facilitatory intracortical circuits in th...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.06.012
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Although one of the most frequent diagnosed mental illnesses worldwide, it appears to be challenging to successfully treat major depressive disorder (MDD). Although the phenomenon of treatment-resistant depression (TRD) still remains unclear, the subgenual anterior cingulate cortex (sgACC) has been put forwa...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2015.01.415
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) is a surgical neuromodulation procedure with a historically wide range of possible therapeutic indications, including movement disorders, neuropsychiatric conditions, and cognitive disorders. Ongoing research in this field is critical to gain further insights into the mechanisms ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.11.008
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Conventional rTMS protocols for major depression commonly employ stimulation sessions lasting >30 min. However, recent studies have sought to improve costs, capacities, and outcomes by employing briefer protocols such as theta burst stimulation (iTBS). OBJECTIVE:To compare safety, effectiveness, and outcome...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.11.002
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS), a neuromodulatory non-invasive brain stimulation technique, has shown promising results in basic and clinical studies. The known interindividual variability of the effects, however, limits the efficacy of the technique. Recently we reported neurophysiological e...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2021.01.016
更新日期：2021-01-28 00:00:00
abstract：BACKGROUND:Recently, navigated transcranial magnetic stimulation (nTMS) has been suggested to be useful in preoperative functional localization of motor cortex in patients having tumors close to the somatomotor cortex. Resection of tumors in anatomically predicted eloquent areas without adverse effects have emphasized ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.04.012
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) was recently shown to promote recovery of voluntary signs of consciousness in some patients in minimally conscious state (MCS). However, it remains unclear why clinical improvement is only observed in a subgroup of patients. OBJECTIVES:In this retrospective stu...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2015.07.024
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) can provide insights into how differing cognitive contexts produce different brain states, through TMS-based measures of effective connectivity. For instance, in a recent study, the amplitude of the TMS-evoked response (TMS-ER)...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2013.11.004
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Abdominal bilateral vagal stimulation reduces food intake in animals. However, the classical square wave, mA range current generator is poorly effective to evoke action potentials on A∂ and C neurons that represent the majority of vagal neurons at the abdominal level. OBJECTIVE/HYPOTHESIS:METHODS: The curre...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.04.126
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Direct stimulation of the vagus nerve in the neck via surgically implanted electrodes is protective in animal models of stroke. We sought to determine the safety and efficacy of a non-invasive cervical VNS (nVNS) method using surface electrodes applied to the skin overlying the vagus nerve in the neck in a m...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.11.008
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Despite recent developments in navigation and modeling techniques, the type and location of the structures that are activated by transcranial magnetic stimulation (TMS) remain unknown. OBJECTIVE:We studied the relationships between electrophysiological measurements and electric fields induced in the brain t...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.09.011
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Vagus nerve stimulation (VNS) significantly reduces infarct volume in rat models of cerebral ischemia, but the mechanism of this protective effect remains open. HYPOTHESIS:This study tested the hypothesis that non-invasive VNS (nVNS), during transient middle cerebral artery occlusion (MCAO), protects the bl...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.01.034
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation therapy in epilepsy with conflicting results in terms of efficacy and safety. OBJECTIVE:Review the literature about the efficacy and safety of tDCS in epilepsy in humans and animals. METHODS:We searched studies in Pu...
journal_title：Brain stimulation
pub_type： 杂志文章,评审
doi：10.1016/j.brs.2015.01.001
更新日期：2015-05-01 00:00:00
abstract：:The human motor cortex can be activated by transcranial magnetic stimulation (TMS) evoking a high-frequency repetitive discharge of corticospinal neurones. The exact physiologic mechanisms producing the corticospinal activity still remain unclear because of the complexity of the interactions between the currents induc...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2011.07.008
更新日期：2012-10-01 00:00:00
abstract：:Right unilateral ultra-brief electroconvulsive therapy (RUL UB ECT) has been shown to be efficacious with minimal cognitive adverse effects in adult patients with major depression. We present the case of a 14-year-old girl with major depressive disorder with catatonic and psychotic features whose symptoms remitted aft...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2009.07.003
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Accurate data on the sound emitted by transcranial magnetic stimulation (TMS) coils is lacking. METHODS:We recorded the sound waveforms of seven coils with high bandwidth. We estimated the neural stimulation strength by measuring the induced electric field and applying a strength-duration model to account f...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.03.004
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Noninvasive brain stimulation is a powerful way to modify excitability of the cerebral cortex in humans and is increasingly used to treat psychiatric disorders. The observed clinical effects are in the moderate range and it has been suggested that the efficiency of brain stimulation depends on the underlying...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.07.002
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Vagus Nerve Stimulation (VNS) has seizure-suppressing effects but the underlying mechanism is not fully understood. To further elucidate the mechanisms underlying VNS-induced seizure suppression at a neurophysiological level, the present study examined effects of VNS on hippocampal excitability using dentate...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.09.009
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Low-level light therapy (LLLT) with transcranial laser is a non-invasive form of neuroenhancement shown to regulate neuronal metabolism and cognition. Attention bias modification (ABM) is a cognitive intervention designed to improve depression by decreasing negative attentional bias, but to date its efficacy...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2016.05.009
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Although a significant subset of patients with major depressive disorder (MDD) fail to respond to medical or behavioural therapy, deep brain stimulation (DBS) applied to the subgenual cingulate cortex (SCC; sg25) has been shown to reduce depressive symptoms in a subset of patients. This area receives project...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2016.11.013
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Recent evidence suggests that transcranial direct current stimulation (tDCS) may interact with the dopaminergic system to affect cognitive flexibility. Objective/hypotheses: We examined whether putative reduction of dopamine levels through the acute phenylalanine/tyrosine depletion (APTD) procedure and excit...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2019.08.016
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:External trigeminal nerve stimulation (ETNS) is an emergent, non-invasive neurostimulation therapy delivered bilaterally with adhesive skin electrodes. In previous studies, ETNS was associated to a decrease in seizure frequency in patients with focal drug-resistant epilepsy (DRE). OBJECTIVE:To determine the...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.06.005
更新日期：2020-01-01 00:00:00
