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Modulation of Hippocampal Activity by Vagus Nerve Stimulation in Freely Moving Rats.

Abstract：

BACKGROUND:Vagus Nerve Stimulation (VNS) has seizure-suppressing effects but the underlying mechanism is not fully understood. To further elucidate the mechanisms underlying VNS-induced seizure suppression at a neurophysiological level, the present study examined effects of VNS on hippocampal excitability using dentate gyrus evoked potentials (EPs) and hippocampal electroencephalography (EEG). METHODS:Male Sprague-Dawley rats were implanted with a VNS electrode around the left vagus nerve. A bipolar stimulation electrode was implanted in the left perforant path and a bipolar recording electrode was implanted in the left dentate gyrus for EEG and dentate field EP recording. Following recovery, VNS was applied in freely moving animals, using a duty cycle of 7 s on/18 s off, 30 Hz frequency, 250 µs pulse width, and an intensity of either 0 (SHAM), 25 µA or 1000 µA, while continuously monitoring EEG and dentate field EPs. RESULTS:VNS at 1000 µA modulated dentate field EPs by decreasing the field excitatory post-synaptic potential (fEPSP) slope and increasing the latency and amplitude of the population spike. It additionally influenced hippocampal EEG by slowing theta rhythm from 7 Hz to 5 Hz and reducing theta peak and gamma band power. No effects were observed in the SHAM or 25 µA VNS conditions. CONCLUSION:VNS modulated hippocampal excitability of freely moving rats in a complex way. It decreased synaptic efficacy, reflected by decreased fEPSP slope and EEG power, but it simultaneously facilitated dentate granule cell discharge indicating depolarization of dentate granule cells.

journal_name

Brain Stimul

journal_title

Brain stimulation

authors

Larsen LE,Wadman WJ,van Mierlo P,Delbeke J,Grimonprez A,Van Nieuwenhuyse B,Portelli J,Boon P,Vonck K,Raedt R

doi

10.1016/j.brs.2015.09.009

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

124-32

issue

1

eissn

1935-861X

issn

1876-4754

pii

S1935-861X(15)01130-4

journal_volume

9

pub_type

杂志文章

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