Abstract:
:The human motor cortex can be activated by transcranial magnetic stimulation (TMS) evoking a high-frequency repetitive discharge of corticospinal neurones. The exact physiologic mechanisms producing the corticospinal activity still remain unclear because of the complexity of the interactions between the currents induced in the brain and the circuits of cerebral cortex, composed of multiple excitatory and inhibitory neurons and axons of different size, location, orientation and function. The aim of current paper is to evaluate whether the main characteristics of the activity evoked by single- and paired-pulse and repetitive TMS, can be accounted by the interaction of the induced currents in the brain with the key anatomic features of a simple cortical circuit composed of the superficial population of excitatory pyramidal neurons of layers II and III, the large pyramidal neurons in layer V, and the inhibitory GABA cells. This circuit represents the minimum architecture necessary for capturing the most essential cortical input-output operations of neocortex. The interaction between the induced currents in the brain and this simple model of cortical circuitry might explain the characteristics and nature of the repetitive discharge evoked by TMS, including its regular and rhythmic nature and its dose-dependency and pharmacologic modulation. The integrative properties of the circuit also provide a good framework for the interpretation of the changes in the cortical output produced by paired and repetitive TMS.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Di Lazzaro V,Profice P,Ranieri F,Capone F,Dileone M,Oliviero A,Pilato Fdoi
10.1016/j.brs.2011.07.008subject
Has Abstractpub_date
2012-10-01 00:00:00pages
512-25issue
4eissn
1935-861Xissn
1876-4754pii
S1935-861X(11)00115-Xjournal_volume
5pub_type
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journal_title:Brain stimulation
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,meta分析
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journal_title:Brain stimulation
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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更新日期:2016-09-01 00:00:00
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pub_type: 信件,随机对照试验
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pub_type: 临床试验,杂志文章
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更新日期:2018-01-01 00:00:00
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更新日期:2020-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2013.11.002
更新日期:2014-03-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,评审
doi:10.1016/j.brs.2014.07.039
更新日期:2015-01-01 00:00:00
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journal_title:Brain stimulation
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
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更新日期:2016-03-01 00:00:00