Abstract:
BACKGROUND:The ability to exert self-control over temptation is a fundamental component of smoking behavior change. Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) has been shown to modulate cognitive control circuits. Although prior studies show that stimulation reduces cigarette craving and self-reported smoking, effects on ability to resist smoking have not been investigated directly. OBJECTIVES:We assessed effects of a single 20-minute session of 1.0 mA anodal stimulation over the left DLPFC with cathodal stimulation over the right supra-orbital area (vs. sham stimulation) on ability to resist smoking in a validated smoking lapse paradigm. METHODS:Twenty-five participants completed two tDCS sessions (active and sham stimulation) in a within-subject, double-blind, randomized and counterbalanced order with a 2-week washout period. Following overnight abstinence, participants received tDCS in the presence of smoking related cues; they had the option to smoke at any time or receive $1 for every 5 minutes they abstained. After 50 minutes, they participated in a 1 hour ad libitum smoking session. Primary and secondary outcomes were time to first cigarette and cigarette consumption, respectively. RESULTS:In multiple regression models, active tDCS (compared to sham) significantly increased latency to smoke (p = 0.02) and decreased the total number of cigarettes smoked (p = 0.014) during the session. CONCLUSION:These findings suggest that acute anodal stimulation over the left DLPFC (with cathodal stimulation over the right supra-orbital area) can improve ability to resist smoking, supporting the therapeutic potential of tDCS for smoking cessation treatment.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Falcone M,Bernardo L,Ashare RL,Hamilton R,Faseyitan O,McKee SA,Loughead J,Lerman Cdoi
10.1016/j.brs.2015.10.004subject
Has Abstractpub_date
2016-03-01 00:00:00pages
191-6issue
2eissn
1935-861Xissn
1876-4754pii
S1935-861X(15)01214-0journal_volume
9pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Task switching, defined as the ability to flexibly switch between tasks in the face of goal shifting, is a central mechanism in cognitive control. Task switching is thought to involve both prefrontal cortex (PFC) and parietal regions. Our previous work has shown that it is possible to modulate set shifting t...
journal_title:Brain stimulation
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abstract:BACKGROUND:Deep brain stimulation (DBS) in the subcallosal cingulate gyrus (SCG) is becoming an effective therapeutic option for treatment resistant depression (TRD). OBJECTIVE/HYPOTHESIS:Identifying the neurophysiological mechanisms altered by DBS may lead to more tailored treatment parameters and enhanced efficacy. ...
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abstract:BACKGROUND:Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is a treatment for severe childhood-onset dystonia. A common challenge for clinicians is determining which contacts of the DBS electrode to stimulate in order to provide maximum future benefit to the patient. OBJECTIVE:To characterize how th...
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abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown significant efficiency in the treatment of several psychiatric disorders. In depressive disorders, the dorsolateral prefrontal cortex (DLPFC) is the main target for rTMS, but the effects of this stimulation on cognitive functions and their neural ...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. O...
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abstract:CONTEXT:The aim of this study was to assess whether the combination of low frequency repetitive transcranial magnetic stimulation (rTMS) and venlafaxine (150-225 mg/day) is effective and safe for treatment-resistant unipolar depression (TRD). METHOD:In a multicenter (18 centers) randomized double blind controlled tria...
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Accurate data on the sound emitted by transcranial magnetic stimulation (TMS) coils is lacking. METHODS:We recorded the sound waveforms of seven coils with high bandwidth. We estimated the neural stimulation strength by measuring the induced electric field and applying a strength-duration model to account f...
journal_title:Brain stimulation
pub_type: 杂志文章
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
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更新日期:2019-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:The efficacy of transcranial magnetic stimulation (TMS) in the treatment of major depression has already been shown. Novel TMS coils allowing stimulation of deeper brain regions have recently been developed and studied. OBJECTIVE:Our study is aimed at exploring the possible efficacy of deep TMS in patients ...
journal_title:Brain stimulation
pub_type: 杂志文章
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journal_title:Brain stimulation
pub_type: 杂志文章
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2014.05.008
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Neuromodulation therapies are currently being investigated as potential treatments for depression. One of these treatments involves the stimulation of supraorbital branches of the trigeminal nerve. OBJECTIVE:To show that supraorbital stimulation is effective in preclinical models. METHODS:Rats were given s...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2013.11.002
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:In transcranial magnetic stimulation (TMS) a strong, brief current pulse driven through a coil is used for non-invasively stimulating the cortex. Properties of the electric field (E-field) induced by the pulse together with physiological parameters determine the outcome of the stimulation. In research and cl...
journal_title:Brain stimulation
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更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1016/j.brs.2020.02.020
更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.brs.2018.07.043
更新日期:2018-01-01 00:00:00
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journal_title:Brain stimulation
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doi:10.1016/j.brs.2014.01.056
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Transcutaneous spinal direct current stimulation (tsDCS) is a new non-invasive technique to modulate spinal cord activity. The pathophysiological concept of primary RLS proposes increased spinal excitability. OBJECTIVE:This pilot study used tsDCS to reduce pathologically enhanced spinal excitability in RLS ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.06.008
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Although pallidal deep brain stimulation (GPi-DBS) is an effective treatment for dystonia, it may cause important stimulation-induced side-effects such as hypokinetic dysarthria or stuttering. However, the reasons behind the occurrence of these side-effects remain unknown. OBJECTIVE:To objectively investiga...
journal_title:Brain stimulation
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
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更新日期:2015-05-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
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journal_title:Brain stimulation
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更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to induce changes in cortical neural excitability. This report presents findings from the first participant of a safety and efficacy study that examined a therapeutic rTMS protocol for persons with severe traumatic brain injury (TBI)...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2008.09.004
更新日期:2009-01-01 00:00:00
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journal_title:Brain stimulation
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doi:10.1016/j.brs.2020.04.017
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) has been used for neuropsychiatric disorders in clinical and research settings for almost 50 years now. Recent evidence demonstrates some efficacy in treating obsessive-compulsive disorder and major depression in patients refractory to other treatment modalities beyond single cas...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2010.03.002
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression, but only some individuals respond. Predicting response could reduce patient and clinical burden. Neural activity related to working memory (WM) has been related to mood improvements, so may represent a biomarker for...
journal_title:Brain stimulation
pub_type: 临床试验,杂志文章
doi:10.1016/j.brs.2017.10.015
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that primary motor cortex (M1) excitability is modulated by motor skill learning and that the M1 plays a crucial role in motor memory. However, the following questions remain: (1) At what stage do changes in M1 excitability occur? (2) Are learning-induced changes in leg M1 excitab...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.07.025
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Conventional rTMS protocols for major depression commonly employ stimulation sessions lasting >30 min. However, recent studies have sought to improve costs, capacities, and outcomes by employing briefer protocols such as theta burst stimulation (iTBS). OBJECTIVE:To compare safety, effectiveness, and outcome...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.11.002
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Pairing sensory or motor events with vagus nerve stimulation (VNS) can reorganize sensory or motor cortex. Repeatedly pairing a tone with a brief period of VNS increases the proportion of primary auditory cortex (A1) responding to the frequency of the paired tone. However, the relationship between VNS intens...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.08.018
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:In a seminal paper, Galea et al. (Modulation of cerebellar excitability by polarity-specific noninvasive direct current stimulation. 2009. J Neurosci 29, 9115-9122) showed that cerebellar transcranial direct current stimulation (ctDCS) alters cerebellar-M1 connectivity. This effect has been explained by ctDC...
journal_title:Brain stimulation
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00