Abstract:
BACKGROUND:Electroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and future antidepressant research. OBJECTIVE:To determine whether clinical response to ECT is related to structural volumetric changes in the brain as measured by structural magnetic resonance imaging (MRI) and, if so, which regions are related to this clinical effect. We also determine whether a similar model can be used to identify regions associated with electrode placement (unilateral versus bilateral ECT). METHODS:Longitudinal MRI and clinical data (Hamilton Depression Rating Scale) was collected from 10 sites as part of the Global ECT-MRI research collaboration (GEMRIC). From 192 subjects, relative changes in 80 (sub)cortical areas were used as potential features for classifying treatment response. We used recursive feature elimination to extract relevant features, which were subsequently used to train a linear classifier. As a validation, the same was done for electrode placement. We report accuracy as well as the structural coefficients of regions included in the discriminative spatial patterns obtained. RESULTS:A pattern of structural changes in cortical midline, striatal and lateral prefrontal areas discriminates responders from non-responders (75% accuracy, p < 0.001) while left-sided mediotemporal changes discriminate unilateral from bilateral electrode placement (81% accuracy, p < 0.001). CONCLUSIONS:The identification of a multivariate discriminative pattern shows that structural change is relevant for clinical response to ECT, but this pattern does not include mediotemporal regions that have been the focus of electroconvulsive therapy research so far.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Mulders PCR,Llera A,Beckmann CF,Vandenbulcke M,Stek M,Sienaert P,Redlich R,Petrides G,Oudega ML,Oltedal L,Oedegaard KJ,Narr KL,Magnusson PO,Kessler U,Jorgensen A,Espinoza R,Enneking V,Emsell L,Dols A,Dannlowski U,doi
10.1016/j.brs.2020.02.020subject
Has Abstractpub_date
2020-01-01 00:00:00pages
696-704issue
3eissn
1935-861Xissn
1876-4754pii
S1935-861X(20)30042-5journal_volume
13pub_type
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Brain stimulation
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doi:10.1016/j.brs.2011.04.005
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journal_title:Brain stimulation
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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更新日期:2011-10-01 00:00:00
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journal_title:Brain stimulation
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更新日期:2021-01-28 00:00:00
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journal_title:Brain stimulation
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journal_title:Brain stimulation
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更新日期:2018-01-01 00:00:00
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-04-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.09.009
更新日期:2016-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.04.004
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. O...
journal_title:Brain stimulation
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doi:10.1016/j.brs.2017.03.012
更新日期:2017-01-01 00:00:00