Abstract：
CONTEXT:The aim of this study was to assess whether the combination of low frequency repetitive transcranial magnetic stimulation (rTMS) and venlafaxine (150-225 mg/day) is effective and safe for treatment-resistant unipolar depression (TRD). METHOD:In a multicenter (18 centers) randomized double blind controlled trial with three arms, 170 patients were allocated to receive active rTMS combined with active venlafaxine (n = 55), active rTMS combined with placebo venlafaxine (n = 60) or sham rTMS combined with active venlafaxine (n = 55). The patients received once daily sessions of active or sham 1 Hz rTMS applied over the right dorsolateral prefrontal cortex (360 pulses/day delivered at 120% of the resting motor threshold) for two to six weeks; rTMS was combined with active or sham venlafaxine (mean dose: 179.0 ± 36.6 mg/day). The primary outcome was the number of patients who achieved remission, which was defined as an HDRS17 score <8. RESULTS:We reported a similar significant antidepressant effect in the 3 groups (P < 10(-6)), with a comparable delay of action and a comparable number of remitters at the endpoint (28% in the combination group, 41% in the rTMS group and 43% in the venlafaxine group; P = 0.59). CONCLUSION:Low frequency rTMS appears to be as effective as venlafaxine and as effective as the combination of both treatments for TRD. Because of its short session duration (the duration of one session was 8.5 min) and its safety, slow rTMS might be a useful alternative treatment for patients with TRD.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Brunelin J,Jalenques I,Trojak B,Attal J,Szekely D,Gay A,Januel D,Haffen E,Schott-Pethelaz AM,Brault C,STEP Group.,Poulet Edoi
10.1016/j.brs.2014.07.040subject
Has Abstractpub_date
2014-11-01 00:00:00pages
855-63issue
6eissn
1935-861Xissn
1876-4754pii
S1935-861X(14)00269-1journal_volume
7pub_type
杂志文章,多中心研究,随机对照试验abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) was recently shown to promote recovery of voluntary signs of consciousness in some patients in minimally conscious state (MCS). However, it remains unclear why clinical improvement is only observed in a subgroup of patients. OBJECTIVES:In this retrospective stu...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2015.07.024
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Transcranial alternating current stimulation (tACS) has been shown to modulate auditory, visual, cognitive and motor function. However, tACS effects can often be small and difficult to reproduce. Thus, the establishment of robust experimental and analysis procedures is of high importance. We reviewed the ana...
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更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:The ability to exert self-control over temptation is a fundamental component of smoking behavior change. Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) has been shown to modulate cognitive control circuits. Although prior studies show that stimulation reduces cig...
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2015.10.004
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. O...
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abstract：BACKGROUND:Direct stimulation of the vagus nerve in the neck via surgically implanted electrodes is protective in animal models of stroke. We sought to determine the safety and efficacy of a non-invasive cervical VNS (nVNS) method using surface electrodes applied to the skin overlying the vagus nerve in the neck in a m...
journal_title：Brain stimulation
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doi：10.1016/j.brs.2015.11.008
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Non-invasive direct current stimulation (DCS) of the brain induces functional plasticity in vitro and facilitates motor learning across species. The effect of DCS on structural synaptic plasticity is currently unknown. OBJECTIVE:This study addresses the effects and the underlying mechanisms of anodal DCS on...
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doi：10.1016/j.brs.2019.07.026
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abstract：BACKGROUND:Although some studies have reported significant reductions in food cravings following the single-session of repetitive transcranial magnetic stimulation (rTMS), there is little research on the effects of multi-session of rTMS on food consumption and body weight in obese subjects. OBJECTIVE:We conducted 4-we...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2019.07.020
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Dual-site transcranial magnetic stimulation (ds-TMS) is a neurophysiological technique to measure functional connectivity between cortical areas. OBJECTIVE/HYPOTHESIS:To date, no study has used ds-TMS to investigate short intra-hemispheric interactions between the somatosensory areas and primary motor corte...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.04.009
更新日期：2019-01-01 00:00:00
abstract：:After acute stroke several changes in cortical excitability occur involving affected (AH) and unaffected hemisphere (UH) but whether they contribute to motor recovery is still controversial. We performed transcranial magnetic stimulation mapping of several upper limb muscles over the two hemispheres in thirteen patien...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.06.003
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) has emerged as a potential therapeutic strategy in the treatment of neurological disorders including epilepsy. However, the cellular mechanism responsible for the effects of DBS remains largely undefined. Therefore, using electrophysiological approach, we aimed to determine the a...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.11.001
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:The left dorsal premotor cortex (PMd) plays an important role in movement selection and is abnormally activated in imaging studies in patients with right-sided focal hand dystonia (FHD). OBJECTIVE:The aims of this study were to assess the role of left PMd in patients with FHD and in the genesis of surround ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2009.03.004
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Dorsomedial prefrontal cortex (DMPFC) repetitive transcranial magnetic stimulation (rTMS) is a novel intervention for treatment-refractory depression (TRD). To date, many open-label case series and one randomized controlled trial of modest sample size have provided preliminary evidence that DMPFC-rTMS is an ...
journal_title：Brain stimulation
pub_type： 信件,随机对照试验
doi：10.1016/j.brs.2019.10.020
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) is able to modify cortical excitability and activity in humans. OBJECTIVE:The aim of the present study was to analyze the effects of tDCS of the primary sensory cortex (SI) on thermal and mechanical perception, assessed by quantitative sensory testing (QST). M...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.12.002
更新日期：2011-10-01 00:00:00
abstract：:Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the surgical therapy of choice for medically intractable Parkinson's disease. However, quantitative understanding of the interaction between the electric field generated by DBS and the underlying neural tissue is limited. Recently, computational ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.01.003
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:The Perturbational Complexity Index (PCI) was recently introduced to assess the capacity of thalamocortical circuits to engage in complex patterns of causal interactions. While showing high accuracy in detecting consciousness in brain-injured patients, PCI depends on elaborate experimental setups and offline...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.05.013
更新日期：2019-01-01 00:00:00
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journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.03.012
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Despite recent developments in navigation and modeling techniques, the type and location of the structures that are activated by transcranial magnetic stimulation (TMS) remain unknown. OBJECTIVE:We studied the relationships between electrophysiological measurements and electric fields induced in the brain t...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.09.011
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Directional Deep Brain Stimulation (D-DBS) allows axially asymmetric electrical field shaping, away from structures causing side-effects. However, concerns regarding the impact on device lifespan and complexity of the monopolar survey have contributed to sparing use of these features. OBJECTIVE:To investiga...
journal_title：Brain stimulation
pub_type： 临床试验,杂志文章
doi：10.1016/j.brs.2017.12.015
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Accurate data on the sound emitted by transcranial magnetic stimulation (TMS) coils is lacking. METHODS:We recorded the sound waveforms of seven coils with high bandwidth. We estimated the neural stimulation strength by measuring the induced electric field and applying a strength-duration model to account f...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.03.004
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abstract：BACKGROUND:Deep brain stimulation (DBS) has been used for neuropsychiatric disorders in clinical and research settings for almost 50 years now. Recent evidence demonstrates some efficacy in treating obsessive-compulsive disorder and major depression in patients refractory to other treatment modalities beyond single cas...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.03.002
更新日期：2011-01-01 00:00:00
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journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.12.001
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Although cervical vagus nerve stimulation is effective for reducing infarct volume in rats, it is not feasible for acute human stroke as it requires surgical incision of the neck. We hypothesized that stimulation of the dermatome in the external ear innervated by the vagus nerve (auricular vagus nerve stimul...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.09.009
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) can provide insights into how differing cognitive contexts produce different brain states, through TMS-based measures of effective connectivity. For instance, in a recent study, the amplitude of the TMS-evoked response (TMS-ER)...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2013.11.004
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Low-level light therapy (LLLT) with transcranial laser is a non-invasive form of neuroenhancement shown to regulate neuronal metabolism and cognition. Attention bias modification (ABM) is a cognitive intervention designed to improve depression by decreasing negative attentional bias, but to date its efficacy...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2016.05.009
更新日期：2016-09-01 00:00:00
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journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.07.043
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Transcutaneous spinal direct current stimulation (tsDCS) is a new non-invasive technique to modulate spinal cord activity. The pathophysiological concept of primary RLS proposes increased spinal excitability. OBJECTIVE:This pilot study used tsDCS to reduce pathologically enhanced spinal excitability in RLS ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.06.008
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Vagus Nerve Stimulation (VNS) has seizure-suppressing effects but the underlying mechanism is not fully understood. To further elucidate the mechanisms underlying VNS-induced seizure suppression at a neurophysiological level, the present study examined effects of VNS on hippocampal excitability using dentate...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.09.009
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is considered as an effective treatment for adults with major depressive disorder. However, it remains unknown whether rTMS has comparable or better efficacy in adolescents. OBJECTIVE:The current naturalistic study aimed to investigate the efficacy and cli...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.09.007
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS), a neuromodulatory non-invasive brain stimulation technique, has shown promising results in basic and clinical studies. The known interindividual variability of the effects, however, limits the efficacy of the technique. Recently we reported neurophysiological e...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2021.01.016
更新日期：2021-01-28 00:00:00
