Abstract：
BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. OBJECTIVE:The present study aims to (i) determine the most effective stimulation parameters to optimize antidepressant-like effect of tDCS in the forced-swim test in mice and (ii) identify brain regions recruited by tDCS and possibly involved in its behavioral effect using Fos immunohistochemistry. RESULTS:We reported that tDCS induced long-lasting antidepressant-like effect, which varied as a function of stimulation settings including number, duration, intensity and polarity of stimulation. Interestingly, the present study also demonstrated that tDCS reduced depressive-like behaviors induced by chronic corticosterone exposure. Furthermore, behavioral outcomes induced by a single stimulation were associated with neuronal activation in the prefrontal cortex, dorsal hippocampus, ventral tegmental area and nucleus accumbens, whereas no overexpression of c-fos was associated with 10 stimulations. CONCLUSION:The strongest behavioral response was observed with an anodal stimulation of 200 μA during 20min. The repetition of this stimulation was necessary to induce long-lasting behavioral effects that are probably associated with plastic changes in the neuronal response.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Peanlikhit T,Van Waes V,Pedron S,Risold PY,Haffen E,Etiévant A,Monnin Jdoi
10.1016/j.brs.2017.03.012subject
Has Abstractpub_date
2017-01-01 00:00:00pages
748-756issue
4eissn
1935-861Xissn
1876-4754pii
S1935-861X(17)30657-5journal_volume
10pub_type
杂志文章abstract：OBJECTIVES:Vagus nerve stimulation represents an established treatment strategy for epilepsy and affective disorders. Recently, positive effects were also shown in animals and humans with tinnitus. Here we report the results of an open pilot study exploring feasibility, safety and efficacy of tVNS in the treatment of c...
journal_title：Brain stimulation
pub_type： 临床试验,杂志文章
doi：10.1016/j.brs.2014.05.003
更新日期：2014-09-01 00:00:00
abstract：:The intensity of sound emanating from the discharge of magnetic coils used in repetitive transcranial magnetic stimulation (rTMS) can potentially cause acoustic trauma. Per Occupational Safety and Health Administration (OSHA) standards for safety of noise exposure, hearing protection is recommended beyond restricted l...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.01.056
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:The final common pathway in tinnitus generation is considered to be synchronized auditory oscillatory hyperactivity. Intracranial auditory cortex stimulation (iACS) via implanted electrodes has been developed to treat severe cases of intractable tinnitus targeting this final common pathway, in the hope of be...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.04.004
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:In a seminal paper, Galea et al. (Modulation of cerebellar excitability by polarity-specific noninvasive direct current stimulation. 2009. J Neurosci 29, 9115-9122) showed that cerebellar transcranial direct current stimulation (ctDCS) alters cerebellar-M1 connectivity. This effect has been explained by ctDC...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.04.002
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Conventional rTMS protocols for major depression commonly employ stimulation sessions lasting >30 min. However, recent studies have sought to improve costs, capacities, and outcomes by employing briefer protocols such as theta burst stimulation (iTBS). OBJECTIVE:To compare safety, effectiveness, and outcome...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.11.002
更新日期：2015-03-01 00:00:00
abstract：:The human motor cortex can be activated by transcranial magnetic stimulation (TMS) evoking a high-frequency repetitive discharge of corticospinal neurones. The exact physiologic mechanisms producing the corticospinal activity still remain unclear because of the complexity of the interactions between the currents induc...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2011.07.008
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Although cervical vagus nerve stimulation is effective for reducing infarct volume in rats, it is not feasible for acute human stroke as it requires surgical incision of the neck. We hypothesized that stimulation of the dermatome in the external ear innervated by the vagus nerve (auricular vagus nerve stimul...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.09.009
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:No consensus exists in the clinical transcranial magnetic stimulation (TMS) field as to the best method for targeting the left dorsolateral prefrontal cortex (DLPFC) for depression treatment. Two common targeting methods are the Beam F3 method and the 5.5 cm rule. OBJECTIVE:Evaluate the anatomical reliabili...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.01.010
更新日期：2020-01-01 00:00:00
abstract：:Right unilateral ultra-brief electroconvulsive therapy (RUL UB ECT) has been shown to be efficacious with minimal cognitive adverse effects in adult patients with major depression. We present the case of a 14-year-old girl with major depressive disorder with catatonic and psychotic features whose symptoms remitted aft...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2009.07.003
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Although a significant subset of patients with major depressive disorder (MDD) fail to respond to medical or behavioural therapy, deep brain stimulation (DBS) applied to the subgenual cingulate cortex (SCC; sg25) has been shown to reduce depressive symptoms in a subset of patients. This area receives project...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2016.11.013
更新日期：2017-01-01 00:00:00
abstract：:After acute stroke several changes in cortical excitability occur involving affected (AH) and unaffected hemisphere (UH) but whether they contribute to motor recovery is still controversial. We performed transcranial magnetic stimulation mapping of several upper limb muscles over the two hemispheres in thirteen patien...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.06.003
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Although one of the most frequent diagnosed mental illnesses worldwide, it appears to be challenging to successfully treat major depressive disorder (MDD). Although the phenomenon of treatment-resistant depression (TRD) still remains unclear, the subgenual anterior cingulate cortex (sgACC) has been put forwa...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2015.01.415
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Abdominal bilateral vagal stimulation reduces food intake in animals. However, the classical square wave, mA range current generator is poorly effective to evoke action potentials on A∂ and C neurons that represent the majority of vagal neurons at the abdominal level. OBJECTIVE/HYPOTHESIS:METHODS: The curre...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.04.126
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Theta burst stimulation (TBS) is a pattern of repetitive transcranial magnetic stimulation that has been demonstrated to facilitate or suppress human corticospinal excitability when applied intermittently (iTBS) or continuously (cTBS), respectively. While the fundamental pattern of TBS, consisting of bursts ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2013.12.007
更新日期：2014-03-01 00:00:00
abstract：:Deep brain stimulation (DBS) has evolved into a powerful clinical therapy for a range of neurological disorders, but even with impressive clinical growth, DBS technology has been relatively stagnant over its history. However, enhanced collaborations between neural engineers, neuroscientists, physicists, neurologists, ...
journal_title：Brain stimulation
pub_type： 杂志文章,评审
doi：10.1016/j.brs.2014.07.039
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Dual-site transcranial magnetic stimulation (ds-TMS) is a neurophysiological technique to measure functional connectivity between cortical areas. OBJECTIVE/HYPOTHESIS:To date, no study has used ds-TMS to investigate short intra-hemispheric interactions between the somatosensory areas and primary motor corte...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.04.009
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Directional Deep Brain Stimulation (D-DBS) allows axially asymmetric electrical field shaping, away from structures causing side-effects. However, concerns regarding the impact on device lifespan and complexity of the monopolar survey have contributed to sparing use of these features. OBJECTIVE:To investiga...
journal_title：Brain stimulation
pub_type： 临床试验,杂志文章
doi：10.1016/j.brs.2017.12.015
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Non-invasive brain stimulation with transcranial alternating currents (tACS) has been shown to entrain slow cortical oscillations and thereby influence various aspects of visual perception. Much less is known about its potential effects on auditory perception. OBJECTIVE:In the present study, we apply a nove...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.04.004
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Accurate data on the sound emitted by transcranial magnetic stimulation (TMS) coils is lacking. METHODS:We recorded the sound waveforms of seven coils with high bandwidth. We estimated the neural stimulation strength by measuring the induced electric field and applying a strength-duration model to account f...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.03.004
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Transcutaneous spinal direct current stimulation (tsDCS) is a new non-invasive technique to modulate spinal cord activity. The pathophysiological concept of primary RLS proposes increased spinal excitability. OBJECTIVE:This pilot study used tsDCS to reduce pathologically enhanced spinal excitability in RLS ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.06.008
更新日期：2014-09-01 00:00:00
abstract：INTRODUCTION:Previous work in the language domain has shown that 10 Hz rTMS of the left or right posterior inferior frontal gyrus (pIFG) in the prefrontal cortex impaired phonological decision-making, arguing for a causal contribution of the bilateral pIFG to phonological processing. However, the neurophysiological cor...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.06.021
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:The use of repetitive transcranial magnetic stimulation (rTMS) as both therapeutic and experimental tools has grown enormously over the past decade. However, variability in response to rTMS is one challenge that remains to be solved. Estrogen can impact neural plasticity and may also affect plastic changes f...
journal_title：Brain stimulation
pub_type： 临床试验,杂志文章
doi：10.1016/j.brs.2019.05.007
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Pairing sensory or motor events with vagus nerve stimulation (VNS) can reorganize sensory or motor cortex. Repeatedly pairing a tone with a brief period of VNS increases the proportion of primary auditory cortex (A1) responding to the frequency of the paired tone. However, the relationship between VNS intens...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.08.018
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has been proposed for stabilizing the antidepressant effect of sleep deprivation (SD) by preventing the relapse after a night of recovery sleep. In this study, we aimed to replicate these data coming from a small pilot study in a larger patient sample. MET...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2011.02.005
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Transcranial magnetic stimulation (TMS) is a noninvasive neuromodulation technique with therapeutic applications for the treatment of major depressive disorder (MDD). The standard protocol uses high frequency stimulation over the left dorsolateral prefrontal cortex (DLPFC) identified in a heuristic manner le...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.10.004
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Noninvasive brain stimulation is a powerful way to modify excitability of the cerebral cortex in humans and is increasingly used to treat psychiatric disorders. The observed clinical effects are in the moderate range and it has been suggested that the efficiency of brain stimulation depends on the underlying...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.07.002
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Dorsomedial prefrontal cortex (DMPFC) repetitive transcranial magnetic stimulation (rTMS) is a novel intervention for treatment-refractory depression (TRD). To date, many open-label case series and one randomized controlled trial of modest sample size have provided preliminary evidence that DMPFC-rTMS is an ...
journal_title：Brain stimulation
pub_type： 信件,随机对照试验
doi：10.1016/j.brs.2019.10.020
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:the use of combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) for the functional evaluation of the cerebral cortex in health and disease is becoming increasingly common. However, there is still some ambiguity regarding the extent to which brain responses to auditory and somatos...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.10.011
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:The Perturbational Complexity Index (PCI) was recently introduced to assess the capacity of thalamocortical circuits to engage in complex patterns of causal interactions. While showing high accuracy in detecting consciousness in brain-injured patients, PCI depends on elaborate experimental setups and offline...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.05.013
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:External trigeminal nerve stimulation (ETNS) is an emergent, non-invasive neurostimulation therapy delivered bilaterally with adhesive skin electrodes. In previous studies, ETNS was associated to a decrease in seizure frequency in patients with focal drug-resistant epilepsy (DRE). OBJECTIVE:To determine the...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.06.005
更新日期：2020-01-01 00:00:00
