Abstract:
BACKGROUND:Dopaminergic activity within the dorsolateral prefrontal cortex (dlPFC) has been implicated in the control of cognitive flexibility. Much of the evidence for a causative relationship between cognitive flexibility and dopamine has come from animal studies, whilst human data have largely been correlational. OBJECTIVE/HYPOTHESIS:The current study examines whether changes in dopamine levels through tyrosine administration and suppression of dlPFC activity via cathodal tDCS could be causally related to cognitive flexibility as measured by task switching and reversal learning. METHODS:Using a crossover, double-blind, sham controlled, counterbalanced, randomized trial, we tested the effects of combining cathodal tDCS with tyrosine, a catecholaminergic precursor, with appropriate drug and tDCS placebo controls, on two measures of cognitive flexibility: probabilistic reversal learning, and task switching. RESULTS:While none of the manipulations had an effect on task switching, there was a significant main effect of cathodal tDCS and tyrosine on reversal learning. Reversal learning performance was significantly worsened by cathodal tDCS compared with sham tDCS, whilst tyrosine significantly improved performance compared with placebo. However, there was no significant tDCS × drugs interaction. Interestingly, and as predicted by our model, the combined administration of tyrosine with cathodal tDCS resulted in performance that was equivalent to the control condition (i.e. tDCS sham + placebo). CONCLUSIONS:Our results suggest a causative role for dopamine signalling and dorsolateral prefrontal cortex activity in regulating indices of cognitive flexibility in humans.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Dennison O,Gao J,Lim LW,Stagg CJ,Aquili Ldoi
10.1016/j.brs.2018.12.001subject
Has Abstractpub_date
2019-01-01 00:00:00pages
290-295issue
2eissn
1935-861Xissn
1876-4754pii
S1935-861X(18)30419-4journal_volume
12pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Lesions of the angular gyrus (AnG) region of human parietal cortex do not cause amnesia, but appear to be associated with reduction in the ability to consciously experience the reliving of previous events. OBJECTIVES/HYPOTHESIS:We used continuous theta burst stimulation to test the hypothesis that the cogni...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.02.011
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Accurate identification of cranial midline structures is essential for many targeting techniques that use repetitive transcranial magnetic stimulation (rTMS), including the Beam F3 method used for depression treatment. OBJECTIVE:Evaluate whether a novel, laser-sighted device will assist with more accurate i...
journal_title:Brain stimulation
pub_type: 信件
doi:10.1016/j.brs.2019.07.028
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) has been used to improve exercise performance, though the protocols used, and results found are mixed. OBJECTIVE:We aimed to analyze the effect of tDCS on improving exercise performance. METHODS:A systematic search was performed on the following databases, unt...
journal_title:Brain stimulation
pub_type: 杂志文章,meta分析
doi:10.1016/j.brs.2018.12.227
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Temporal lobe epilepsy (TLE) is often associated with memory deficits. Given the putative role for sleep spindles memory consolidation, spindle generators skewed toward the affected lobe in TLE subjects may be a neurophysiological marker of defective memory. Slow-oscillatory transcranial direct current stimu...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2015.01.410
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Neuromodulation therapies are currently being investigated as potential treatments for depression. One of these treatments involves the stimulation of supraorbital branches of the trigeminal nerve. OBJECTIVE:To show that supraorbital stimulation is effective in preclinical models. METHODS:Rats were given s...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2013.11.002
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Transcranial electrical stimulation (tES) shows promise to treat neurological disorders. Knowledge of how the orthogonal components of the electric field (E-field) alter neuronal activity is required for strategic placement of transcranial electrodes. Yet, essentially no information exists on this relationsh...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.08.017
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. Thi...
journal_title:Brain stimulation
pub_type: 信件
doi:10.1016/j.brs.2017.05.002
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) in the subcallosal cingulate gyrus (SCG) is becoming an effective therapeutic option for treatment resistant depression (TRD). OBJECTIVE/HYPOTHESIS:Identifying the neurophysiological mechanisms altered by DBS may lead to more tailored treatment parameters and enhanced efficacy. ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.06.010
更新日期:2015-11-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,meta分析
doi:10.1016/j.brs.2018.12.002
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) is a surgical neuromodulation procedure with a historically wide range of possible therapeutic indications, including movement disorders, neuropsychiatric conditions, and cognitive disorders. Ongoing research in this field is critical to gain further insights into the mechanisms ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.11.008
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression, but only some individuals respond. Predicting response could reduce patient and clinical burden. Neural activity related to working memory (WM) has been related to mood improvements, so may represent a biomarker for...
journal_title:Brain stimulation
pub_type: 临床试验,杂志文章
doi:10.1016/j.brs.2017.10.015
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (TMS) is a non-invasive, safe, and efficacious treatment for depression. TMS has been shown to normalize abnormal functional connectivity of cortico-cortical circuits in depression and baseline functional connectivity of these circuits predicts treatment response....
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.07.002
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:A prime objective driving the recent development of human neural prosthetics is to stimulate neural circuits in a manner time-locked to ongoing brain activity. The human supplementary motor area (SMA) is a particularly useful target for this objective because it displays characteristic neural activity just p...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.03.003
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:A session of motor skill learning is accompanied by transient increases in corticospinal excitability(CSE), which are thought to reflect acute changes in neuronal connectivity associated with improvements in sensorimotor performance. Factors influencing changes in excitability and motor skill with continued ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.11.005
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Traditional transcranial magnetic stimulation mapping involves systematically delivering stimuli over a predefined grid. The pseudorandom walk method seeks to improve map acquisition times by abandoning the grid in favour of delivering stimuli randomly over a given area. OBJECTIVES:To i) determine the minim...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.07.043
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Temporal resolution of cortical, auditory processing mechanisms is suggested to be linked to peak frequency of neuronal gamma oscillations in auditory cortex areas (individual gamma frequency, IGF): Individuals with higher IGF tend to have better temporal resolution. HYPOTHESIS:Modulating ongoing gamma acti...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.10.008
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Although a significant subset of patients with major depressive disorder (MDD) fail to respond to medical or behavioural therapy, deep brain stimulation (DBS) applied to the subgenual cingulate cortex (SCC; sg25) has been shown to reduce depressive symptoms in a subset of patients. This area receives project...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2016.11.013
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation of the ventro-intermedius nucleus of the thalamus is an established treatment for tremor of differing etiologies but factors that may predict the short- and especially long-term outcome of surgery are still largely unknown. METHODS:We retrospectively investigated the clinical, pharmac...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.12.014
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:There is much interest in whether daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) over several weeks may become a clinically useful antidepressant treatment. Although rTMS appears largely safe, many patients report that this procedure is somewhat painful, which may restrict its ulti...
journal_title:Brain stimulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.brs.2008.09.001
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:No consensus exists in the clinical transcranial magnetic stimulation (TMS) field as to the best method for targeting the left dorsolateral prefrontal cortex (DLPFC) for depression treatment. Two common targeting methods are the Beam F3 method and the 5.5 cm rule. OBJECTIVE:Evaluate the anatomical reliabili...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.01.010
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is able to modify cortical excitability and activity in humans. OBJECTIVE:The aim of the present study was to analyze the effects of tDCS of the primary sensory cortex (SI) on thermal and mechanical perception, assessed by quantitative sensory testing (QST). M...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2010.12.002
更新日期:2011-10-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.01.056
更新日期:2014-05-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.06.008
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown significant efficiency in the treatment of several psychiatric disorders. In depressive disorders, the dorsolateral prefrontal cortex (DLPFC) is the main target for rTMS, but the effects of this stimulation on cognitive functions and their neural ...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2012.10.009
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Directional Deep Brain Stimulation (D-DBS) allows axially asymmetric electrical field shaping, away from structures causing side-effects. However, concerns regarding the impact on device lifespan and complexity of the monopolar survey have contributed to sparing use of these features. OBJECTIVE:To investiga...
journal_title:Brain stimulation
pub_type: 临床试验,杂志文章
doi:10.1016/j.brs.2017.12.015
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) has been used for neuropsychiatric disorders in clinical and research settings for almost 50 years now. Recent evidence demonstrates some efficacy in treating obsessive-compulsive disorder and major depression in patients refractory to other treatment modalities beyond single cas...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2010.03.002
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Balance problems contribute to reduced quality of life in Parkinson's disease (PD) and available treatments are often insufficient for treating axial and postural motor symptoms. OBJECTIVE:To investigate the safety of use and possible effects of stochastic vestibular stimulation (SVS) alone and combined wit...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2014.11.019
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Non-invasive direct current stimulation (DCS) of the brain induces functional plasticity in vitro and facilitates motor learning across species. The effect of DCS on structural synaptic plasticity is currently unknown. OBJECTIVE:This study addresses the effects and the underlying mechanisms of anodal DCS on...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.07.026
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Vagus Nerve Stimulation (VNS) has seizure-suppressing effects but the underlying mechanism is not fully understood. To further elucidate the mechanisms underlying VNS-induced seizure suppression at a neurophysiological level, the present study examined effects of VNS on hippocampal excitability using dentate...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.09.009
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) for the experimental treatment of tinnitus or auditory hallucinations aims at a modulation of cortical activity in areas of auditory perception and processing. Continuous theta burst stimulation (cTBS) is a patterned rTMS paradigm with lower stimulation int...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2012.10.005
更新日期:2013-07-01 00:00:00