Abstract:
BACKGROUND:Transcutaneous spinal direct current stimulation (tsDCS) is a new non-invasive technique to modulate spinal cord activity. The pathophysiological concept of primary RLS proposes increased spinal excitability. OBJECTIVE:This pilot study used tsDCS to reduce pathologically enhanced spinal excitability in RLS patients and to thereby ameliorate clinical symptoms. METHODS:20 patients with idiopathic RLS and 14 healthy subjects participated in this double-blinded, placebo-controlled study. All participants received one session of cathodal, anodal and sham stimulation of the thoracic spinal cord for 15 min (2.5 mA) each, in randomized order during their symptomatic phase in the evening. The soleus Hoffmann-reflex with Hmax/Mmax-ratio and seven different H2/H1-ratios (of two H-reflex responses to double stimuli) were measured. The RLS symptoms were assessed by a visual analogue scale (VAS). All parameters were measured before and twice after tsDCS. RESULTS:RLS patients showed increased H2/H1-ratios during their symptomatic phase in the evening. Application of anodal stimulation led to a decreased H2/H1-ratio for 0.2 and 0.3 s interstimulus intervals in patients. Furthermore, application of anodal and cathodal stimulation led to a reduction in restless legs symptoms on the VAS, whereas application of sham stimulation had no effects on either the VAS or on the H2/H1-ratio in patients. VAS changes did not correlate with changes of H2/H1-ratios. CONCLUSIONS:This is the first tsDCS study in idiopathic RLS, which resulted in short-lasting clinical improvement. Furthermore, our results support the pathophysiological concept of spinal cord hyperexcitability in primary RLS and provide the basis for a new non-pharmacological treatment tool.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Heide AC,Winkler T,Helms HJ,Nitsche MA,Trenkwalder C,Paulus W,Bachmann CGdoi
10.1016/j.brs.2014.06.008subject
Has Abstractpub_date
2014-09-01 00:00:00pages
636-42issue
5eissn
1935-861Xissn
1876-4754pii
S1935-861X(14)00188-0journal_volume
7pub_type
杂志文章abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) was recently shown to promote recovery of voluntary signs of consciousness in some patients in minimally conscious state (MCS). However, it remains unclear why clinical improvement is only observed in a subgroup of patients. OBJECTIVES:In this retrospective stu...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2015.07.024
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown promise as a treatment for refractory auditory hallucinations (AH) in Schizophrenia. Most previous studies have examined the effect of low frequency, left-sided stimulation (LFL) (1 Hz) to the temporoparietal cortex (TPC). Priming stimulation (6 H...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2011.12.002
更新日期:2012-10-01 00:00:00
abstract::The human motor cortex can be activated by transcranial magnetic stimulation (TMS) evoking a high-frequency repetitive discharge of corticospinal neurones. The exact physiologic mechanisms producing the corticospinal activity still remain unclear because of the complexity of the interactions between the currents induc...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2011.07.008
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Neuroimaging studies suggest that facial expression recognition is processed in the bilateral posterior superior temporal sulcus (pSTS). Our recent repetitive transcranial magnetic stimulation (rTMS) study demonstrates that the bilateral pSTS is causally involved in expression recognition, although involveme...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.04.011
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that primary motor cortex (M1) excitability is modulated by motor skill learning and that the M1 plays a crucial role in motor memory. However, the following questions remain: (1) At what stage do changes in M1 excitability occur? (2) Are learning-induced changes in leg M1 excitab...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.07.025
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is a treatment for severe childhood-onset dystonia. A common challenge for clinicians is determining which contacts of the DBS electrode to stimulate in order to provide maximum future benefit to the patient. OBJECTIVE:To characterize how th...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.06.003
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:A growing body of evidence suggests that deficits in GABAergic inhibitory and glutamatergic excitatory neurotransmission may be involved in the core pathophysiology of generalized anxiety disorder (GAD), a disease characterized by pathological anxious worrying. The aim of the present study was to measure mot...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2016.12.007
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Although a significant subset of patients with major depressive disorder (MDD) fail to respond to medical or behavioural therapy, deep brain stimulation (DBS) applied to the subgenual cingulate cortex (SCC; sg25) has been shown to reduce depressive symptoms in a subset of patients. This area receives project...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2016.11.013
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Many individuals with language learning impairments exhibit temporal processing deficits and degraded neural responses to speech sounds. Auditory training can improve both the neural and behavioral deficits, though significant deficits remain. Recent evidence suggests that vagus nerve stimulation (VNS) paire...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.01.007
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) in the subcallosal cingulate gyrus (SCG) is becoming an effective therapeutic option for treatment resistant depression (TRD). OBJECTIVE/HYPOTHESIS:Identifying the neurophysiological mechanisms altered by DBS may lead to more tailored treatment parameters and enhanced efficacy. ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.06.010
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:In a seminal paper, Galea et al. (Modulation of cerebellar excitability by polarity-specific noninvasive direct current stimulation. 2009. J Neurosci 29, 9115-9122) showed that cerebellar transcranial direct current stimulation (ctDCS) alters cerebellar-M1 connectivity. This effect has been explained by ctDC...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.04.002
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Task switching, defined as the ability to flexibly switch between tasks in the face of goal shifting, is a central mechanism in cognitive control. Task switching is thought to involve both prefrontal cortex (PFC) and parietal regions. Our previous work has shown that it is possible to modulate set shifting t...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.10.006
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:White matter hyperintensities (WMH) are estimated to occur in greater than 63% of older adults over the age of 60 years. WMH identified in the T2-weighted FLAIR images can be combined with T1-weighted images to enhance individualized current flow models of older adults by accounting for the presence of WMH a...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.11.009
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Despite recent developments in navigation and modeling techniques, the type and location of the structures that are activated by transcranial magnetic stimulation (TMS) remain unknown. OBJECTIVE:We studied the relationships between electrophysiological measurements and electric fields induced in the brain t...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.09.011
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Lesions of the angular gyrus (AnG) region of human parietal cortex do not cause amnesia, but appear to be associated with reduction in the ability to consciously experience the reliving of previous events. OBJECTIVES/HYPOTHESIS:We used continuous theta burst stimulation to test the hypothesis that the cogni...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.02.011
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:In transcranial magnetic stimulation (TMS) a strong, brief current pulse driven through a coil is used for non-invasively stimulating the cortex. Properties of the electric field (E-field) induced by the pulse together with physiological parameters determine the outcome of the stimulation. In research and cl...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.01.004
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Transcranial electrical stimulation (tES) shows promise to treat neurological disorders. Knowledge of how the orthogonal components of the electric field (E-field) alter neuronal activity is required for strategic placement of transcranial electrodes. Yet, essentially no information exists on this relationsh...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.08.017
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:There is much interest in whether daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) over several weeks may become a clinically useful antidepressant treatment. Although rTMS appears largely safe, many patients report that this procedure is somewhat painful, which may restrict its ulti...
journal_title:Brain stimulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.brs.2008.09.001
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. O...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.03.012
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Temporal lobe epilepsy (TLE) is often associated with memory deficits. Given the putative role for sleep spindles memory consolidation, spindle generators skewed toward the affected lobe in TLE subjects may be a neurophysiological marker of defective memory. Slow-oscillatory transcranial direct current stimu...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2015.01.410
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Movies and television (TV) programs are an important source of public information about ECT. OBJECTIVE:To narratively review the portrayal of ECT in international movies and TV programs from 1948 until present. METHODS:Several Internet movie databases and a database of phrases appearing in movies and TV pr...
journal_title:Brain stimulation
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.brs.2016.07.005
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Previous work in the language domain has shown that 10 Hz rTMS of the left or right posterior inferior frontal gyrus (pIFG) in the prefrontal cortex impaired phonological decision-making, arguing for a causal contribution of the bilateral pIFG to phonological processing. However, the neurophysiological cor...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.06.021
更新日期:2019-01-01 00:00:00
abstract::Inhibitory control mechanisms are important in a range of behaviours to prevent execution of motor acts which, having been planned, are no longer necessary or appropriate. Examples of this can be seen in a range of sports, such as cricket and baseball, where the choice between execution and inhibition of a bat swing m...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.03.012
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) is a surgical neuromodulation procedure with a historically wide range of possible therapeutic indications, including movement disorders, neuropsychiatric conditions, and cognitive disorders. Ongoing research in this field is critical to gain further insights into the mechanisms ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.11.008
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation therapy in epilepsy with conflicting results in terms of efficacy and safety. OBJECTIVE:Review the literature about the efficacy and safety of tDCS in epilepsy in humans and animals. METHODS:We searched studies in Pu...
journal_title:Brain stimulation
pub_type: 杂志文章,评审
doi:10.1016/j.brs.2015.01.001
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Chronic severe tinnitus can be greatly detrimental to quality of life. Some authors have reported benefit of repetitive transcranial magnetic stimulation, others of electrical cortical stimulation by stimulating the Heschl's gyrus or secondary auditory areas. OBJECTIVE:To evaluate the efficacy of chronic el...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2014.05.008
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulatory technique that has broad diagnostic and therapeutic potential across a range of neurological and psychiatric diseases. OBJECTIVE:This study utilises a bibliometric approach to systematically and comprehensively evaluate the literature...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.01.002
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. Thi...
journal_title:Brain stimulation
pub_type: 信件
doi:10.1016/j.brs.2017.05.002
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Animal models of Parkinson's Disease (PD) demonstrated increased facilitatory cortico-striatal activity, reflecting overactive glutamatergic neurotransmission and contributing to the pathophysiology of l-dopa induced dyskinesias (LIDs). OBJECTIVE:To assess different facilitatory intracortical circuits in th...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.06.012
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Burning mouth syndrome (BMS) is a burning oral sensation without any corresponding abnormal findings. In some cases, BMS is refractory to pharmacologic treatments. Repetitive transcranial magnetic stimulation (rTMS) over left prefrontal cortex induces analgesic effect in both acute and chronic pain. However,...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2015.10.005
更新日期:2016-03-01 00:00:00