Abstract：
BACKGROUND:A growing body of evidence suggests that deficits in GABAergic inhibitory and glutamatergic excitatory neurotransmission may be involved in the core pathophysiology of generalized anxiety disorder (GAD), a disease characterized by pathological anxious worrying. The aim of the present study was to measure motor cortical excitability by paired-pulse transcranial magnetic stimulation (ppTMS) in patients with GAD. METHODS:ppTMS measurements of excitation and inhibition from bilateral motor cortices were investigated in 26 right-handed GAD patients who were drug-naïve (half of them with a comorbidity of major depressive disorder) and 35 right-handed age- and sex-matched healthy controls. Short-interval intracortical inhibition (SICI), intracortical facilitation (ICF), and long-interval intracortical inhibition (LICI) were studied; evidence indicated that these are mainly mediated by GABA-A receptors, glutamate receptors, and GABA-B receptors, respectively. RESULTS:After correcting for multiple comparisons, GAD patients had significantly lower left ICF (p < 0.001, Cohen's d = 1.348) and right ICF (p = 0.001, Cohen's d = 0.963), but not SICI and LICI, than did healthy controls. No significant difference of the ICF values was found between GAD with and without depressive disorders. Multivariate linear regression analysis revealed that left ICF (B = -4.990, 95% CI = -8.821 to -1.039, p = 0.007) and group (B = 13.179, 95% CI = 10.208 to 16.149, p = 0.001) predicted anxiety symptoms significantly. CONCLUSION:The present study provided direct evidence to support that generalized anxiety disorder is characterized by impaired intra-cortical facilitation of motor cortex, suggesting glutamate-related excitatory dysfunction may play a key role in pathological anxiety.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Li CT,Lu CF,Lin HC,Huang YZ,Juan CH,Su TP,Bai YM,Chen MH,Lin WCdoi
10.1016/j.brs.2016.12.007subject
Has Abstractpub_date
2017-01-01 00:00:00pages
604-608issue
3eissn
1935-861Xissn
1876-4754pii
S1935-861X(16)30389-8journal_volume
10pub_type
杂志文章abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown significant efficiency in the treatment of several psychiatric disorders. In depressive disorders, the dorsolateral prefrontal cortex (DLPFC) is the main target for rTMS, but the effects of this stimulation on cognitive functions and their neural ...
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2015.08.011
更新日期：2016-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2011.02.005
更新日期：2012-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.brs.2014.09.009
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. O...
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pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Brain stimulation
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
