Abstract：
BACKGROUND:The left dorsal premotor cortex (PMd) plays an important role in movement selection and is abnormally activated in imaging studies in patients with right-sided focal hand dystonia (FHD). OBJECTIVE:The aims of this study were to assess the role of left PMd in patients with FHD and in the genesis of surround inhibition, which is deficient in FHD. METHODS:Single- and paired-pulse transcranial magnetic stimulation (TMS) was applied during different phases of an index finger movement using the abductor pollicis brevis muscle (APB), a surrounding, nonsynergistic muscle, as target muscle. To look at the effect of PMd on the primary motor cortex (M1), a subthreshold conditioning pulse was applied to PMd 6 milliseconds before stimulation over M1. RESULTS:There was surround inhibition during movement initiation in controls, but not in FHD patients. In contrast, FHD patients, but not controls, showed premotor-motor inhibition (PMI) at rest. During movement, PMI was absent in both groups. CONCLUSIONS:We conclude that PMI does not appear to play a key role in the formation of surround inhibition in normal subjects, because it was not enhanced during movement initiation. However, in FHD, inhibition from PMd on M1 was abnormally increased at rest and declined during movement initiation. The behavior of PMd can therefore partly explain the loss of surround inhibition in the FHD patients. The functional significance of increased PMI at rest is not clear, but might be an attempt of compensation for losses of inhibition from other brain areas.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Beck S,Houdayer E,Richardson SP,Hallett Mdoi
10.1016/j.brs.2009.03.004subject
Has Abstractpub_date
2009-10-01 00:00:00pages
208-14issue
4eissn
1935-861Xissn
1876-4754pii
S1935-861X(09)00034-5journal_volume
2pub_type
杂志文章abstract：BACKGROUND:Dual-site transcranial magnetic stimulation (ds-TMS) is a neurophysiological technique to measure functional connectivity between cortical areas. OBJECTIVE/HYPOTHESIS:To date, no study has used ds-TMS to investigate short intra-hemispheric interactions between the somatosensory areas and primary motor corte...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.04.009
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Transcutaneous spinal direct current stimulation (tsDCS) is a new non-invasive technique to modulate spinal cord activity. The pathophysiological concept of primary RLS proposes increased spinal excitability. OBJECTIVE:This pilot study used tsDCS to reduce pathologically enhanced spinal excitability in RLS ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.06.008
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Accurate data on the sound emitted by transcranial magnetic stimulation (TMS) coils is lacking. METHODS:We recorded the sound waveforms of seven coils with high bandwidth. We estimated the neural stimulation strength by measuring the induced electric field and applying a strength-duration model to account f...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.03.004
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) for the experimental treatment of tinnitus or auditory hallucinations aims at a modulation of cortical activity in areas of auditory perception and processing. Continuous theta burst stimulation (cTBS) is a patterned rTMS paradigm with lower stimulation int...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2012.10.005
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:the use of combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) for the functional evaluation of the cerebral cortex in health and disease is becoming increasingly common. However, there is still some ambiguity regarding the extent to which brain responses to auditory and somatos...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.10.011
更新日期：2021-01-01 00:00:00
abstract：:The human motor cortex can be activated by transcranial magnetic stimulation (TMS) evoking a high-frequency repetitive discharge of corticospinal neurones. The exact physiologic mechanisms producing the corticospinal activity still remain unclear because of the complexity of the interactions between the currents induc...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2011.07.008
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Movies and television (TV) programs are an important source of public information about ECT. OBJECTIVE:To narratively review the portrayal of ECT in international movies and TV programs from 1948 until present. METHODS:Several Internet movie databases and a database of phrases appearing in movies and TV pr...
journal_title：Brain stimulation
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.brs.2016.07.005
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is considered as an effective treatment for adults with major depressive disorder. However, it remains unknown whether rTMS has comparable or better efficacy in adolescents. OBJECTIVE:The current naturalistic study aimed to investigate the efficacy and cli...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.09.007
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) is able to modify cortical excitability and activity in humans. OBJECTIVE:The aim of the present study was to analyze the effects of tDCS of the primary sensory cortex (SI) on thermal and mechanical perception, assessed by quantitative sensory testing (QST). M...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.12.002
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) can provide insights into how differing cognitive contexts produce different brain states, through TMS-based measures of effective connectivity. For instance, in a recent study, the amplitude of the TMS-evoked response (TMS-ER)...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2013.11.004
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Traditional transcranial magnetic stimulation mapping involves systematically delivering stimuli over a predefined grid. The pseudorandom walk method seeks to improve map acquisition times by abandoning the grid in favour of delivering stimuli randomly over a given area. OBJECTIVES:To i) determine the minim...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.07.043
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Many individuals with language learning impairments exhibit temporal processing deficits and degraded neural responses to speech sounds. Auditory training can improve both the neural and behavioral deficits, though significant deficits remain. Recent evidence suggests that vagus nerve stimulation (VNS) paire...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.01.007
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Despite recent developments in navigation and modeling techniques, the type and location of the structures that are activated by transcranial magnetic stimulation (TMS) remain unknown. OBJECTIVE:We studied the relationships between electrophysiological measurements and electric fields induced in the brain t...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.09.011
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Theories of executive control propose that communication between medial frontal cortex (MFC) and lateral prefrontal cortex (lPFC) is critical for learning. 6-Hz phase synchronization may be the mechanism by which neural activity between MFC and lPFC is coordinated into a functional network. Recent evidence s...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.02.008
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) in the subcallosal cingulate gyrus (SCG) is becoming an effective therapeutic option for treatment resistant depression (TRD). OBJECTIVE/HYPOTHESIS:Identifying the neurophysiological mechanisms altered by DBS may lead to more tailored treatment parameters and enhanced efficacy. ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.06.010
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Electroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and future antidepressant research. OBJECTIVE:To determine whether clinical response to ECT is related t...
journal_title：Brain stimulation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.brs.2020.02.020
更新日期：2020-01-01 00:00:00
abstract：:Although rTMS is moving steadily into the mainstream as a treatment for medically refractory depression, its efficacy continues to lag behind that of more invasive neuromodulation treatments such as ECT or DBS. Here we review evidence to suggest that a fruitful, but neglected, strategy for improving rTMS efficacy may ...
journal_title：Brain stimulation
pub_type： 杂志文章,评审
doi：10.1016/j.brs.2012.08.006
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:The Perturbational Complexity Index (PCI) was recently introduced to assess the capacity of thalamocortical circuits to engage in complex patterns of causal interactions. While showing high accuracy in detecting consciousness in brain-injured patients, PCI depends on elaborate experimental setups and offline...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.05.013
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. Thi...
journal_title：Brain stimulation
pub_type： 信件
doi：10.1016/j.brs.2017.05.002
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Direct stimulation of the vagus nerve in the neck via surgically implanted electrodes is protective in animal models of stroke. We sought to determine the safety and efficacy of a non-invasive cervical VNS (nVNS) method using surface electrodes applied to the skin overlying the vagus nerve in the neck in a m...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.11.008
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Balance problems contribute to reduced quality of life in Parkinson's disease (PD) and available treatments are often insufficient for treating axial and postural motor symptoms. OBJECTIVE:To investigate the safety of use and possible effects of stochastic vestibular stimulation (SVS) alone and combined wit...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2014.11.019
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) has been used for neuropsychiatric disorders in clinical and research settings for almost 50 years now. Recent evidence demonstrates some efficacy in treating obsessive-compulsive disorder and major depression in patients refractory to other treatment modalities beyond single cas...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.03.002
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulatory technique that has broad diagnostic and therapeutic potential across a range of neurological and psychiatric diseases. OBJECTIVE:This study utilises a bibliometric approach to systematically and comprehensively evaluate the literature...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.01.002
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is a treatment for severe childhood-onset dystonia. A common challenge for clinicians is determining which contacts of the DBS electrode to stimulate in order to provide maximum future benefit to the patient. OBJECTIVE:To characterize how th...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.06.003
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Although cervical vagus nerve stimulation is effective for reducing infarct volume in rats, it is not feasible for acute human stroke as it requires surgical incision of the neck. We hypothesized that stimulation of the dermatome in the external ear innervated by the vagus nerve (auricular vagus nerve stimul...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.09.009
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Noninvasive brain stimulation is a powerful way to modify excitability of the cerebral cortex in humans and is increasingly used to treat psychiatric disorders. The observed clinical effects are in the moderate range and it has been suggested that the efficiency of brain stimulation depends on the underlying...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.07.002
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Temporal lobe epilepsy (TLE) is often associated with memory deficits. Given the putative role for sleep spindles memory consolidation, spindle generators skewed toward the affected lobe in TLE subjects may be a neurophysiological marker of defective memory. Slow-oscillatory transcranial direct current stimu...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2015.01.410
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:There has been an explosion of interest in methods of exogenous brain stimulation that induce changes in the excitability of human cerebral cortex. The expectation is that these methods may promote recovery of function following brain injury. To assess their effects on motor output, it is typical to assess t...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2013.01.016
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:A prime objective driving the recent development of human neural prosthetics is to stimulate neural circuits in a manner time-locked to ongoing brain activity. The human supplementary motor area (SMA) is a particularly useful target for this objective because it displays characteristic neural activity just p...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.03.003
更新日期：2018-01-01 00:00:00
abstract：CONTEXT:The aim of this study was to assess whether the combination of low frequency repetitive transcranial magnetic stimulation (rTMS) and venlafaxine (150-225 mg/day) is effective and safe for treatment-resistant unipolar depression (TRD). METHOD:In a multicenter (18 centers) randomized double blind controlled tria...
journal_title：Brain stimulation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.brs.2014.07.040
更新日期：2014-11-01 00:00:00
