Abstract：
BACKGROUND:Many individuals with language learning impairments exhibit temporal processing deficits and degraded neural responses to speech sounds. Auditory training can improve both the neural and behavioral deficits, though significant deficits remain. Recent evidence suggests that vagus nerve stimulation (VNS) paired with rehabilitative therapies enhances both cortical plasticity and recovery of normal function. OBJECTIVE/HYPOTHESIS:We predicted that pairing VNS with rapid tone trains would enhance the primary auditory cortex (A1) response to unpaired novel speech sounds. METHODS:VNS was paired with tone trains 300 times per day for 20 days in adult rats. Responses to isolated speech sounds, compressed speech sounds, word sequences, and compressed word sequences were recorded in A1 following the completion of VNS-tone train pairing. RESULTS:Pairing VNS with rapid tone trains resulted in stronger, faster, and more discriminable A1 responses to speech sounds presented at conversational rates. CONCLUSION:This study extends previous findings by documenting that VNS paired with rapid tone trains altered the neural response to novel unpaired speech sounds. Future studies are necessary to determine whether pairing VNS with appropriate auditory stimuli could potentially be used to improve both neural responses to speech sounds and speech perception in individuals with receptive language disorders.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Engineer CT,Shetake JA,Engineer ND,Vrana WA,Wolf JT,Kilgard MPdoi
10.1016/j.brs.2017.01.007subject
Has Abstractpub_date
2017-01-01 00:00:00pages
543-552issue
3eissn
1935-861Xissn
1876-4754pii
S1935-861X(17)30007-4journal_volume
10pub_type
杂志文章abstract：BACKGROUND:Although cervical vagus nerve stimulation is effective for reducing infarct volume in rats, it is not feasible for acute human stroke as it requires surgical incision of the neck. We hypothesized that stimulation of the dermatome in the external ear innervated by the vagus nerve (auricular vagus nerve stimul...
journal_title：Brain stimulation
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：Brain stimulation
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Dual-site transcranial magnetic stimulation (ds-TMS) is a neurophysiological technique to measure functional connectivity between cortical areas. OBJECTIVE/HYPOTHESIS:To date, no study has used ds-TMS to investigate short intra-hemispheric interactions between the somatosensory areas and primary motor corte...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.04.009
更新日期：2019-01-01 00:00:00
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journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.08.018
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) can provide insights into how differing cognitive contexts produce different brain states, through TMS-based measures of effective connectivity. For instance, in a recent study, the amplitude of the TMS-evoked response (TMS-ER)...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2013.11.004
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Although a significant subset of patients with major depressive disorder (MDD) fail to respond to medical or behavioural therapy, deep brain stimulation (DBS) applied to the subgenual cingulate cortex (SCC; sg25) has been shown to reduce depressive symptoms in a subset of patients. This area receives project...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2016.11.013
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Balance problems contribute to reduced quality of life in Parkinson's disease (PD) and available treatments are often insufficient for treating axial and postural motor symptoms. OBJECTIVE:To investigate the safety of use and possible effects of stochastic vestibular stimulation (SVS) alone and combined wit...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
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更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Neuromodulation therapies are currently being investigated as potential treatments for depression. One of these treatments involves the stimulation of supraorbital branches of the trigeminal nerve. OBJECTIVE:To show that supraorbital stimulation is effective in preclinical models. METHODS:Rats were given s...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2013.11.002
更新日期：2014-03-01 00:00:00
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journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2019.08.016
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Previous studies have shown that primary motor cortex (M1) excitability is modulated by motor skill learning and that the M1 plays a crucial role in motor memory. However, the following questions remain: (1) At what stage do changes in M1 excitability occur? (2) Are learning-induced changes in leg M1 excitab...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.07.025
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS), a neuromodulatory non-invasive brain stimulation technique, has shown promising results in basic and clinical studies. The known interindividual variability of the effects, however, limits the efficacy of the technique. Recently we reported neurophysiological e...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2021.01.016
更新日期：2021-01-28 00:00:00
abstract：BACKGROUND:Theories of executive control propose that communication between medial frontal cortex (MFC) and lateral prefrontal cortex (lPFC) is critical for learning. 6-Hz phase synchronization may be the mechanism by which neural activity between MFC and lPFC is coordinated into a functional network. Recent evidence s...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.02.008
更新日期：2018-01-01 00:00:00
abstract：:Inhibitory control mechanisms are important in a range of behaviours to prevent execution of motor acts which, having been planned, are no longer necessary or appropriate. Examples of this can be seen in a range of sports, such as cricket and baseball, where the choice between execution and inhibition of a bat swing m...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.03.012
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To assay peripheral inter-ictal cytokine serum levels and possible relations with non-invasive vagus nerve stimulation (nVNS) responsiveness in migraineurs. METHODS:This double-blinded, sham-controlled study enrolled 48 subjects and measured headache severity, frequency [headache days/month, number of total ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.01.008
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Recently, navigated transcranial magnetic stimulation (nTMS) has been suggested to be useful in preoperative functional localization of motor cortex in patients having tumors close to the somatomotor cortex. Resection of tumors in anatomically predicted eloquent areas without adverse effects have emphasized ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.04.012
更新日期：2013-05-01 00:00:00
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journal_title：Brain stimulation
pub_type： 临床试验,杂志文章
doi：10.1016/j.brs.2019.05.007
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Vagus Nerve Stimulation (VNS) has seizure-suppressing effects but the underlying mechanism is not fully understood. To further elucidate the mechanisms underlying VNS-induced seizure suppression at a neurophysiological level, the present study examined effects of VNS on hippocampal excitability using dentate...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.09.009
更新日期：2016-01-01 00:00:00
abstract：:After acute stroke several changes in cortical excitability occur involving affected (AH) and unaffected hemisphere (UH) but whether they contribute to motor recovery is still controversial. We performed transcranial magnetic stimulation mapping of several upper limb muscles over the two hemispheres in thirteen patien...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.06.003
更新日期：2013-05-01 00:00:00
abstract：:Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the surgical therapy of choice for medically intractable Parkinson's disease. However, quantitative understanding of the interaction between the electric field generated by DBS and the underlying neural tissue is limited. Recently, computational ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.01.003
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression, but only some individuals respond. Predicting response could reduce patient and clinical burden. Neural activity related to working memory (WM) has been related to mood improvements, so may represent a biomarker for...
journal_title：Brain stimulation
pub_type： 临床试验,杂志文章
doi：10.1016/j.brs.2017.10.015
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Although pallidal deep brain stimulation (GPi-DBS) is an effective treatment for dystonia, it may cause important stimulation-induced side-effects such as hypokinetic dysarthria or stuttering. However, the reasons behind the occurrence of these side-effects remain unknown. OBJECTIVE:To objectively investiga...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.03.007
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has been proposed for stabilizing the antidepressant effect of sleep deprivation (SD) by preventing the relapse after a night of recovery sleep. In this study, we aimed to replicate these data coming from a small pilot study in a larger patient sample. MET...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2011.02.005
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown promise as a treatment for refractory auditory hallucinations (AH) in Schizophrenia. Most previous studies have examined the effect of low frequency, left-sided stimulation (LFL) (1 Hz) to the temporoparietal cortex (TPC). Priming stimulation (6 H...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2011.12.002
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:A growing body of evidence suggests that deficits in GABAergic inhibitory and glutamatergic excitatory neurotransmission may be involved in the core pathophysiology of generalized anxiety disorder (GAD), a disease characterized by pathological anxious worrying. The aim of the present study was to measure mot...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2016.12.007
更新日期：2017-01-01 00:00:00
abstract：:The human motor cortex can be activated by transcranial magnetic stimulation (TMS) evoking a high-frequency repetitive discharge of corticospinal neurones. The exact physiologic mechanisms producing the corticospinal activity still remain unclear because of the complexity of the interactions between the currents induc...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2011.07.008
更新日期：2012-10-01 00:00:00
abstract：:Although rTMS is moving steadily into the mainstream as a treatment for medically refractory depression, its efficacy continues to lag behind that of more invasive neuromodulation treatments such as ECT or DBS. Here we review evidence to suggest that a fruitful, but neglected, strategy for improving rTMS efficacy may ...
journal_title：Brain stimulation
pub_type： 杂志文章,评审
doi：10.1016/j.brs.2012.08.006
更新日期：2013-05-01 00:00:00
abstract：CONTEXT:The aim of this study was to assess whether the combination of low frequency repetitive transcranial magnetic stimulation (rTMS) and venlafaxine (150-225 mg/day) is effective and safe for treatment-resistant unipolar depression (TRD). METHOD:In a multicenter (18 centers) randomized double blind controlled tria...
journal_title：Brain stimulation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.brs.2014.07.040
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Noninvasive brain stimulation is a powerful way to modify excitability of the cerebral cortex in humans and is increasingly used to treat psychiatric disorders. The observed clinical effects are in the moderate range and it has been suggested that the efficiency of brain stimulation depends on the underlying...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.07.002
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:There has been an explosion of interest in methods of exogenous brain stimulation that induce changes in the excitability of human cerebral cortex. The expectation is that these methods may promote recovery of function following brain injury. To assess their effects on motor output, it is typical to assess t...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2013.01.016
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) is able to modify cortical excitability and activity in humans. OBJECTIVE:The aim of the present study was to analyze the effects of tDCS of the primary sensory cortex (SI) on thermal and mechanical perception, assessed by quantitative sensory testing (QST). M...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.12.002
更新日期：2011-10-01 00:00:00
