Abstract：
BACKGROUND:There has been an explosion of interest in methods of exogenous brain stimulation that induce changes in the excitability of human cerebral cortex. The expectation is that these methods may promote recovery of function following brain injury. To assess their effects on motor output, it is typical to assess the state of corticospinal projections from primary motor cortex to muscles of the hand, via electromyographic responses to transcranial magnetic stimulation. If a range of stimulation intensities is employed, the recruitment curves (RCs) obtained can, at least for intrinsic hand muscles, be fitted by a sigmoid function. OBJECTIVE/HYPOTHESIS:To establish whether sigmoid fits provide a reliable basis upon which to characterize the input-output properties of the corticospinal pathway for muscles proximal to the hand, and to assess as an alternative the area under the (recruitment) curve (AURC). METHODS:A comparison of the reliability of these measures, using RCs obtained for muscles that are frequently the targets of rehabilitation. RESULTS:The AURC is an extremely reliable measure of the state of corticospinal projections to hand and forearm muscles, which has both face and concurrent validity. Construct validity is demonstrated by detection of widely distributed (across muscles) changes in corticospinal excitability induced by paired associative stimulation (PAS). CONCLUSION(S):The parameters derived from sigmoid fits are unlikely to provide an adequate means to assess the effectiveness of therapeutic regimes. The AURC can be employed to characterize corticospinal projections to a range of muscles, and gauge the efficacy of longitudinal interventions in clinical rehabilitation.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Carson RG,Nelson BD,Buick AR,Carroll TJ,Kennedy NC,Cann RMdoi
10.1016/j.brs.2013.01.016subject
Has Abstractpub_date
2013-09-01 00:00:00pages
760-8issue
5eissn
1935-861Xissn
1876-4754pii
S1935-861X(13)00039-9journal_volume
6pub_type
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pub_type： 历史文章,杂志文章,评审
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pub_type： 临床试验,杂志文章
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abstract：BACKGROUND:Transcranial direct current stimulation (tDCS), a neuromodulatory non-invasive brain stimulation technique, has shown promising results in basic and clinical studies. The known interindividual variability of the effects, however, limits the efficacy of the technique. Recently we reported neurophysiological e...
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更新日期：2021-01-28 00:00:00
