Abstract:
BACKGROUND:Deep brain stimulation of the ventro-intermedius nucleus of the thalamus is an established treatment for tremor of differing etiologies but factors that may predict the short- and especially long-term outcome of surgery are still largely unknown. METHODS:We retrospectively investigated the clinical, pharmacological, electrophysiological and anatomical features that might predict the initial response and preservation of benefit in all patients who underwent deep brain stimulation for tremor. Data were collected at the following time points: baseline (preoperative), one-year post-surgery, and most recent visit. Tremor severity was recorded using the Fahn-Tolosa-Marin Tremor Rating Scale and/or the Unified Parkinson's Disease Rating Scale. RESULTS:A total of 52 patients were included in the final analysis: 31 with essential tremor, 15 with cerebellar tremor of different etiologies, and 6 with Parkinson's disease. Long-term success (mean follow-up duration 34.7 months, range 1.7-121.1 months) was reported in 63.5%. Predictors of long-term benefit were: underlying tremor etiology (best outcome in Parkinson's disease, worst outcome in cerebellar tremor); age at surgery (the older the better); baseline tremor severity (the greater the better); lack of response to benzodiazepines; a more anterior electrode placement and single-unit beta power (the greater the better). CONCLUSIONS:Specific patients' features (including single unit beta activity) and electrode locations may predict the short- and long-term benefit of thalamic stimulation for tremor. Future prospective studies enrolling a much larger sample of patients are needed to substantiate the associations detected by this retrospective study.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Sandoe C,Krishna V,Basha D,Sammartino F,Tatsch J,Picillo M,di Biase L,Poon YY,Hamani C,Reddy D,Munhoz RP,Lozano AM,Hutchison WD,Fasano Adoi
10.1016/j.brs.2017.12.014subject
Has Abstractpub_date
2018-01-01 00:00:00pages
592-599issue
3eissn
1935-861Xissn
1876-4754pii
S1935-861X(17)31030-6journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Dopamine agonist therapy and deep brain stimulation (DBS) of the subthalamic nucleus (STN) are antiparkinsonian treatments that act on a different part of the basal ganglia-thalamocortical motor circuitry, yet produce similar symptomatic improvements. OBJECTIVE/HYPOTHESIS:The purpose of this study was to id...
journal_title:Brain stimulation
pub_type: 杂志文章
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2014.11.019
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to induce changes in cortical neural excitability. This report presents findings from the first participant of a safety and efficacy study that examined a therapeutic rTMS protocol for persons with severe traumatic brain injury (TBI)...
journal_title:Brain stimulation
pub_type: 杂志文章
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abstract:BACKGROUND:Although one of the most frequent diagnosed mental illnesses worldwide, it appears to be challenging to successfully treat major depressive disorder (MDD). Although the phenomenon of treatment-resistant depression (TRD) still remains unclear, the subgenual anterior cingulate cortex (sgACC) has been put forwa...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2015.01.415
更新日期:2015-07-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2011.07.008
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Volume increases of the hippocampus after electroconvulsive therapy (ECT) are a robust finding, pointing into the direction of neurogenesis. However, such volumetric increases could also be explained by edema and/or neuroplastic changes (such as angiogenesis). OBJECTIVES:If edema explains the volume increas...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.04.017
更新日期:2020-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2015.08.011
更新日期:2016-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.03.012
更新日期:2012-04-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.07.025
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Transcranial alternating current stimulation (tACS) has been shown to modulate auditory, visual, cognitive and motor function. However, tACS effects can often be small and difficult to reproduce. Thus, the establishment of robust experimental and analysis procedures is of high importance. We reviewed the ana...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.03.011
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation therapy in epilepsy with conflicting results in terms of efficacy and safety. OBJECTIVE:Review the literature about the efficacy and safety of tDCS in epilepsy in humans and animals. METHODS:We searched studies in Pu...
journal_title:Brain stimulation
pub_type: 杂志文章,评审
doi:10.1016/j.brs.2015.01.001
更新日期:2015-05-01 00:00:00
abstract::Right unilateral ultra-brief electroconvulsive therapy (RUL UB ECT) has been shown to be efficacious with minimal cognitive adverse effects in adult patients with major depression. We present the case of a 14-year-old girl with major depressive disorder with catatonic and psychotic features whose symptoms remitted aft...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2009.07.003
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Although a significant subset of patients with major depressive disorder (MDD) fail to respond to medical or behavioural therapy, deep brain stimulation (DBS) applied to the subgenual cingulate cortex (SCC; sg25) has been shown to reduce depressive symptoms in a subset of patients. This area receives project...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2016.11.013
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Noninvasive brain stimulation is a powerful way to modify excitability of the cerebral cortex in humans and is increasingly used to treat psychiatric disorders. The observed clinical effects are in the moderate range and it has been suggested that the efficiency of brain stimulation depends on the underlying...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2010.07.002
更新日期:2011-04-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.11.002
更新日期:2015-03-01 00:00:00
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journal_title:Brain stimulation
pub_type: 临床试验,杂志文章
doi:10.1016/j.brs.2014.05.003
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS), a neuromodulatory non-invasive brain stimulation technique, has shown promising results in basic and clinical studies. The known interindividual variability of the effects, however, limits the efficacy of the technique. Recently we reported neurophysiological e...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2021.01.016
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:The Perturbational Complexity Index (PCI) was recently introduced to assess the capacity of thalamocortical circuits to engage in complex patterns of causal interactions. While showing high accuracy in detecting consciousness in brain-injured patients, PCI depends on elaborate experimental setups and offline...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.05.013
更新日期:2019-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,多中心研究
doi:10.1016/j.brs.2020.02.020
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Direct stimulation of the vagus nerve in the neck via surgically implanted electrodes is protective in animal models of stroke. We sought to determine the safety and efficacy of a non-invasive cervical VNS (nVNS) method using surface electrodes applied to the skin overlying the vagus nerve in the neck in a m...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.11.008
更新日期:2016-03-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.01.008
更新日期:2019-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,评审
doi:10.1016/j.brs.2014.07.039
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Non-invasive brain stimulation with transcranial alternating currents (tACS) has been shown to entrain slow cortical oscillations and thereby influence various aspects of visual perception. Much less is known about its potential effects on auditory perception. OBJECTIVE:In the present study, we apply a nove...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.04.004
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION:Previous work in the language domain has shown that 10 Hz rTMS of the left or right posterior inferior frontal gyrus (pIFG) in the prefrontal cortex impaired phonological decision-making, arguing for a causal contribution of the bilateral pIFG to phonological processing. However, the neurophysiological cor...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.06.021
更新日期:2019-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,meta分析
doi:10.1016/j.brs.2018.12.002
更新日期:2019-01-01 00:00:00
abstract::Although rTMS is moving steadily into the mainstream as a treatment for medically refractory depression, its efficacy continues to lag behind that of more invasive neuromodulation treatments such as ECT or DBS. Here we review evidence to suggest that a fruitful, but neglected, strategy for improving rTMS efficacy may ...
journal_title:Brain stimulation
pub_type: 杂志文章,评审
doi:10.1016/j.brs.2012.08.006
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:No consensus exists in the clinical transcranial magnetic stimulation (TMS) field as to the best method for targeting the left dorsolateral prefrontal cortex (DLPFC) for depression treatment. Two common targeting methods are the Beam F3 method and the 5.5 cm rule. OBJECTIVE:Evaluate the anatomical reliabili...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.01.010
更新日期:2020-01-01 00:00:00
abstract::After acute stroke several changes in cortical excitability occur involving affected (AH) and unaffected hemisphere (UH) but whether they contribute to motor recovery is still controversial. We performed transcranial magnetic stimulation mapping of several upper limb muscles over the two hemispheres in thirteen patien...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.06.003
更新日期:2013-05-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.01.034
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Cognitive dysfunction is commonly observed in diabetic patients. We have previously reported that anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex can facilitate visuospatial working memory in diabetic patients with concomitant diabetic peripheral neuropathy and m...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.08.007
更新日期:2017-01-01 00:00:00