Abstract：
BACKGROUND:Despite recent developments in navigation and modeling techniques, the type and location of the structures that are activated by transcranial magnetic stimulation (TMS) remain unknown. OBJECTIVE:We studied the relationships between electrophysiological measurements and electric fields induced in the brain to locate the TMS activation site. METHODS:The active and resting motor thresholds of the first dorsal interosseous muscle were recorded in 19 subjects (7 female, 12 male, age 22 ± 4 years) using anteromedially oriented monophasic TMS at multiple locations over the left primary motor cortex (M1). Structural MR images were used to construct electric field models of each subject's head and brain. The cortical activation site was estimated by finding where the calculated electric fields best explained the coil-location dependency of the measured MTs. RESULTS:The experiments and modeling showed individual variations both in the measured motor thresholds (MTs) and in the computed electric fields. When the TMS coil was moved on the scalp, the calculated electric fields in the hand knob region were shown to vary consistently with the measured MTs. Group-level analysis indicated that the electric fields were significantly correlated with the measured MTs. The strongest correlations (R2 = 0.69), which indicated the most likely activation site, were found in the ventral and lateral part of the hand knob. The site was independent of voluntary contractions of the target muscle. CONCLUSION:The study showed that TMS combined with personalized electric field modeling can be used for high-resolution mapping of the motor cortex.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Laakso I,Murakami T,Hirata A,Ugawa Ydoi
10.1016/j.brs.2017.09.011subject
Has Abstractpub_date
2018-01-01 00:00:00pages
166-174issue
1eissn
1935-861Xissn
1876-4754pii
S1935-861X(17)30903-8journal_volume
11pub_type
杂志文章abstract：:Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the surgical therapy of choice for medically intractable Parkinson's disease. However, quantitative understanding of the interaction between the electric field generated by DBS and the underlying neural tissue is limited. Recently, computational ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.01.003
更新日期：2010-04-01 00:00:00
abstract：:Deep brain stimulation (DBS) has evolved into a powerful clinical therapy for a range of neurological disorders, but even with impressive clinical growth, DBS technology has been relatively stagnant over its history. However, enhanced collaborations between neural engineers, neuroscientists, physicists, neurologists, ...
journal_title：Brain stimulation
pub_type： 杂志文章,评审
doi：10.1016/j.brs.2014.07.039
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:the use of combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) for the functional evaluation of the cerebral cortex in health and disease is becoming increasingly common. However, there is still some ambiguity regarding the extent to which brain responses to auditory and somatos...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.10.011
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:No consensus exists in the clinical transcranial magnetic stimulation (TMS) field as to the best method for targeting the left dorsolateral prefrontal cortex (DLPFC) for depression treatment. Two common targeting methods are the Beam F3 method and the 5.5 cm rule. OBJECTIVE:Evaluate the anatomical reliabili...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.01.010
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Although a significant subset of patients with major depressive disorder (MDD) fail to respond to medical or behavioural therapy, deep brain stimulation (DBS) applied to the subgenual cingulate cortex (SCC; sg25) has been shown to reduce depressive symptoms in a subset of patients. This area receives project...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2016.11.013
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Noninvasive brain stimulation is a powerful way to modify excitability of the cerebral cortex in humans and is increasingly used to treat psychiatric disorders. The observed clinical effects are in the moderate range and it has been suggested that the efficiency of brain stimulation depends on the underlying...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.07.002
更新日期：2011-04-01 00:00:00
abstract：:Inhibitory control mechanisms are important in a range of behaviours to prevent execution of motor acts which, having been planned, are no longer necessary or appropriate. Examples of this can be seen in a range of sports, such as cricket and baseball, where the choice between execution and inhibition of a bat swing m...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.03.012
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Non-invasive direct current stimulation (DCS) of the brain induces functional plasticity in vitro and facilitates motor learning across species. The effect of DCS on structural synaptic plasticity is currently unknown. OBJECTIVE:This study addresses the effects and the underlying mechanisms of anodal DCS on...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.07.026
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Understanding actions based on either language or observation of gestures is presumed to involve the motor system, and reflect the engagement of an embodied conceptual network. The role of the left inferior frontal gyrus (IFG) in language tasks is well established, but the role of the right hemisphere is unc...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.12.001
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) for the experimental treatment of tinnitus or auditory hallucinations aims at a modulation of cortical activity in areas of auditory perception and processing. Continuous theta burst stimulation (cTBS) is a patterned rTMS paradigm with lower stimulation int...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2012.10.005
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Animal models of Parkinson's Disease (PD) demonstrated increased facilitatory cortico-striatal activity, reflecting overactive glutamatergic neurotransmission and contributing to the pathophysiology of l-dopa induced dyskinesias (LIDs). OBJECTIVE:To assess different facilitatory intracortical circuits in th...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.06.012
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:A prime objective driving the recent development of human neural prosthetics is to stimulate neural circuits in a manner time-locked to ongoing brain activity. The human supplementary motor area (SMA) is a particularly useful target for this objective because it displays characteristic neural activity just p...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.03.003
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Temporal lobe epilepsy (TLE) is often associated with memory deficits. Given the putative role for sleep spindles memory consolidation, spindle generators skewed toward the affected lobe in TLE subjects may be a neurophysiological marker of defective memory. Slow-oscillatory transcranial direct current stimu...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2015.01.410
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Vagus nerve stimulation (VNS) paired with forelimb training drives robust, specific reorganization of movement representations in the motor cortex. The mechanisms that underlie VNS-dependent enhancement of map plasticity are largely unknown. The cholinergic nucleus basalis (NB) is a critical substrate in cor...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.12.007
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:The efficacy of transcranial magnetic stimulation (TMS) in the treatment of major depression has already been shown. Novel TMS coils allowing stimulation of deeper brain regions have recently been developed and studied. OBJECTIVE:Our study is aimed at exploring the possible efficacy of deep TMS in patients ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2009.12.001
更新日期：2010-10-01 00:00:00
abstract：CONTEXT:The aim of this study was to assess whether the combination of low frequency repetitive transcranial magnetic stimulation (rTMS) and venlafaxine (150-225 mg/day) is effective and safe for treatment-resistant unipolar depression (TRD). METHOD:In a multicenter (18 centers) randomized double blind controlled tria...
journal_title：Brain stimulation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.brs.2014.07.040
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Accurate data on the sound emitted by transcranial magnetic stimulation (TMS) coils is lacking. METHODS:We recorded the sound waveforms of seven coils with high bandwidth. We estimated the neural stimulation strength by measuring the induced electric field and applying a strength-duration model to account f...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.03.004
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Task switching, defined as the ability to flexibly switch between tasks in the face of goal shifting, is a central mechanism in cognitive control. Task switching is thought to involve both prefrontal cortex (PFC) and parietal regions. Our previous work has shown that it is possible to modulate set shifting t...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2012.10.006
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Studies have found that pairing vagus nerve stimulation (VNS) with motor activity accelerates cortical reorganization. This synchronous pairing may enhance motor recovery. OBJECTIVE:To develop and validate a motor-activated auricular vagus nerve stimulation (MAAVNS) system as a potential neurorehabilitation...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.02.028
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown promise as a treatment for refractory auditory hallucinations (AH) in Schizophrenia. Most previous studies have examined the effect of low frequency, left-sided stimulation (LFL) (1 Hz) to the temporoparietal cortex (TPC). Priming stimulation (6 H...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2011.12.002
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Transcutaneous vagus nerve stimulation (tVNS) is a new, non-invasive technique being investigated as an intervention for a variety of clinical disorders, including epilepsy and depression. It is thought to exert its therapeutic effect by increasing central norepinephrine (NE) activity, but the evidence suppo...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.12.224
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) has been used to improve exercise performance, though the protocols used, and results found are mixed. OBJECTIVE:We aimed to analyze the effect of tDCS on improving exercise performance. METHODS:A systematic search was performed on the following databases, unt...
journal_title：Brain stimulation
pub_type： 杂志文章,meta分析
doi：10.1016/j.brs.2018.12.227
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) in the subcallosal cingulate gyrus (SCG) is becoming an effective therapeutic option for treatment resistant depression (TRD). OBJECTIVE/HYPOTHESIS:Identifying the neurophysiological mechanisms altered by DBS may lead to more tailored treatment parameters and enhanced efficacy. ...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.06.010
更新日期：2015-11-01 00:00:00
abstract：:Right unilateral ultra-brief electroconvulsive therapy (RUL UB ECT) has been shown to be efficacious with minimal cognitive adverse effects in adult patients with major depression. We present the case of a 14-year-old girl with major depressive disorder with catatonic and psychotic features whose symptoms remitted aft...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2009.07.003
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:A growing body of evidence suggests that deficits in GABAergic inhibitory and glutamatergic excitatory neurotransmission may be involved in the core pathophysiology of generalized anxiety disorder (GAD), a disease characterized by pathological anxious worrying. The aim of the present study was to measure mot...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2016.12.007
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Balance problems contribute to reduced quality of life in Parkinson's disease (PD) and available treatments are often insufficient for treating axial and postural motor symptoms. OBJECTIVE:To investigate the safety of use and possible effects of stochastic vestibular stimulation (SVS) alone and combined wit...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2014.11.019
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:External trigeminal nerve stimulation (ETNS) is an emergent, non-invasive neurostimulation therapy delivered bilaterally with adhesive skin electrodes. In previous studies, ETNS was associated to a decrease in seizure frequency in patients with focal drug-resistant epilepsy (DRE). OBJECTIVE:To determine the...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.06.005
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Movies and television (TV) programs are an important source of public information about ECT. OBJECTIVE:To narratively review the portrayal of ECT in international movies and TV programs from 1948 until present. METHODS:Several Internet movie databases and a database of phrases appearing in movies and TV pr...
journal_title：Brain stimulation
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.brs.2016.07.005
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulatory technique that has broad diagnostic and therapeutic potential across a range of neurological and psychiatric diseases. OBJECTIVE:This study utilises a bibliometric approach to systematically and comprehensively evaluate the literature...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.01.002
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. O...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.03.012
更新日期：2017-01-01 00:00:00
