Abstract：
BACKGROUND:Brain derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of depression and the antidepressant response. Electroconvulsive therapy (ECT) is reported to increase BDNF levels in blood, though only a small number of studies have been conducted to date. OBJECTIVE:Our objectives were to: 1) compare plasma BDNF levels in medicated patients with depression and controls; 2) assess the effect of ECT on plasma BDNF levels in medicated patients with depression; 3) explore the relationship between plasma BDNF levels and the Val66Met (rs6265) BDNF polymorphism; and 4) examine the relationship between plasma BDNF levels and clinical symptoms and outcomes with ECT. METHODS:Plasma BDNF levels were analyzed in samples from 61 medicated patients with a major depressive episode and 50 healthy controls, and in patient samples following a course of ECT. Fifty-two samples from the depressed patient group were genotyped for the Val66Met BDNF polymorphism. RESULTS:There was no difference in plasma BDNF levels between the control and depressed groups, and there was no difference in plasma BDNF levels in patients following treatment with ECT. In line with previous reports, we show that, in medicated patients with depression, Met-carriers had higher plasma BDNF levels than Val-carriers, though genotype was not related to clinical response. We found no association between plasma BDNF levels and depression severity or the clinical response to ECT. CONCLUSIONS:Our results suggest that plasma BDNF does not represent a suitable candidate biomarker for determining the therapeutic response to ECT.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Ryan KM,Dunne R,McLoughlin DMdoi
10.1016/j.brs.2018.05.011subject
Has Abstractpub_date
2018-01-01 00:00:00pages
1123-1131issue
5eissn
1935-861Xissn
1876-4754pii
S1935-861X(18)30158-Xjournal_volume
11pub_type
杂志文章abstract：BACKGROUND:There has been an explosion of interest in methods of exogenous brain stimulation that induce changes in the excitability of human cerebral cortex. The expectation is that these methods may promote recovery of function following brain injury. To assess their effects on motor output, it is typical to assess t...
journal_title：Brain stimulation
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abstract：BACKGROUND:Transcranial direct current stimulation (tDCS), a neuromodulatory non-invasive brain stimulation technique, has shown promising results in basic and clinical studies. The known interindividual variability of the effects, however, limits the efficacy of the technique. Recently we reported neurophysiological e...
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journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.08.018
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Lesions of the angular gyrus (AnG) region of human parietal cortex do not cause amnesia, but appear to be associated with reduction in the ability to consciously experience the reliving of previous events. OBJECTIVES/HYPOTHESIS:We used continuous theta burst stimulation to test the hypothesis that the cogni...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.02.011
更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/j.brs.2020.02.028
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journal_title：Brain stimulation
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doi：10.1016/j.brs.2017.12.014
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journal_title：Brain stimulation
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更新日期：2019-01-01 00:00:00
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journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.12.001
更新日期：2015-05-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2014.11.019
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) has been used for neuropsychiatric disorders in clinical and research settings for almost 50 years now. Recent evidence demonstrates some efficacy in treating obsessive-compulsive disorder and major depression in patients refractory to other treatment modalities beyond single cas...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2010.03.002
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:No consensus exists in the clinical transcranial magnetic stimulation (TMS) field as to the best method for targeting the left dorsolateral prefrontal cortex (DLPFC) for depression treatment. Two common targeting methods are the Beam F3 method and the 5.5 cm rule. OBJECTIVE:Evaluate the anatomical reliabili...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.01.010
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) for the experimental treatment of tinnitus or auditory hallucinations aims at a modulation of cortical activity in areas of auditory perception and processing. Continuous theta burst stimulation (cTBS) is a patterned rTMS paradigm with lower stimulation int...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2012.10.005
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:A growing body of evidence suggests that deficits in GABAergic inhibitory and glutamatergic excitatory neurotransmission may be involved in the core pathophysiology of generalized anxiety disorder (GAD), a disease characterized by pathological anxious worrying. The aim of the present study was to measure mot...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2016.12.007
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Movies and television (TV) programs are an important source of public information about ECT. OBJECTIVE:To narratively review the portrayal of ECT in international movies and TV programs from 1948 until present. METHODS:Several Internet movie databases and a database of phrases appearing in movies and TV pr...
journal_title：Brain stimulation
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.brs.2016.07.005
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Although pallidal deep brain stimulation (GPi-DBS) is an effective treatment for dystonia, it may cause important stimulation-induced side-effects such as hypokinetic dysarthria or stuttering. However, the reasons behind the occurrence of these side-effects remain unknown. OBJECTIVE:To objectively investiga...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2018.03.007
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:In transcranial magnetic stimulation (TMS) a strong, brief current pulse driven through a coil is used for non-invasively stimulating the cortex. Properties of the electric field (E-field) induced by the pulse together with physiological parameters determine the outcome of the stimulation. In research and cl...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2015.01.004
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Dopamine agonist therapy and deep brain stimulation (DBS) of the subthalamic nucleus (STN) are antiparkinsonian treatments that act on a different part of the basal ganglia-thalamocortical motor circuitry, yet produce similar symptomatic improvements. OBJECTIVE/HYPOTHESIS:The purpose of this study was to id...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2011.09.002
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Neuromodulation therapies are currently being investigated as potential treatments for depression. One of these treatments involves the stimulation of supraorbital branches of the trigeminal nerve. OBJECTIVE:To show that supraorbital stimulation is effective in preclinical models. METHODS:Rats were given s...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2013.11.002
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:The final common pathway in tinnitus generation is considered to be synchronized auditory oscillatory hyperactivity. Intracranial auditory cortex stimulation (iACS) via implanted electrodes has been developed to treat severe cases of intractable tinnitus targeting this final common pathway, in the hope of be...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.04.004
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Dopaminergic activity within the dorsolateral prefrontal cortex (dlPFC) has been implicated in the control of cognitive flexibility. Much of the evidence for a causative relationship between cognitive flexibility and dopamine has come from animal studies, whilst human data have largely been correlational. O...
journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2018.12.001
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (TMS) is a non-invasive, safe, and efficacious treatment for depression. TMS has been shown to normalize abnormal functional connectivity of cortico-cortical circuits in depression and baseline functional connectivity of these circuits predicts treatment response....
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.07.002
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation therapy in epilepsy with conflicting results in terms of efficacy and safety. OBJECTIVE:Review the literature about the efficacy and safety of tDCS in epilepsy in humans and animals. METHODS:We searched studies in Pu...
journal_title：Brain stimulation
pub_type： 杂志文章,评审
doi：10.1016/j.brs.2015.01.001
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Directional Deep Brain Stimulation (D-DBS) allows axially asymmetric electrical field shaping, away from structures causing side-effects. However, concerns regarding the impact on device lifespan and complexity of the monopolar survey have contributed to sparing use of these features. OBJECTIVE:To investiga...
journal_title：Brain stimulation
pub_type： 临床试验,杂志文章
doi：10.1016/j.brs.2017.12.015
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Conventional rTMS protocols for major depression commonly employ stimulation sessions lasting >30 min. However, recent studies have sought to improve costs, capacities, and outcomes by employing briefer protocols such as theta burst stimulation (iTBS). OBJECTIVE:To compare safety, effectiveness, and outcome...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2014.11.002
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:The Perturbational Complexity Index (PCI) was recently introduced to assess the capacity of thalamocortical circuits to engage in complex patterns of causal interactions. While showing high accuracy in detecting consciousness in brain-injured patients, PCI depends on elaborate experimental setups and offline...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2019.05.013
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. O...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.03.012
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Volume increases of the hippocampus after electroconvulsive therapy (ECT) are a robust finding, pointing into the direction of neurogenesis. However, such volumetric increases could also be explained by edema and/or neuroplastic changes (such as angiogenesis). OBJECTIVES:If edema explains the volume increas...
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2020.04.017
更新日期：2020-01-01 00:00:00
