Abstract:
BACKGROUND:Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation therapy in epilepsy with conflicting results in terms of efficacy and safety. OBJECTIVE:Review the literature about the efficacy and safety of tDCS in epilepsy in humans and animals. METHODS:We searched studies in PubMed, MedLine, Scopus, Web of Science and Google Scholar (January 1969 to October 2013) using the keywords 'transcranial direct current stimulation' or 'tDCS' or 'brain polarization' or 'galvanic stimulation' and 'epilepsy' in animals and humans. Original articles that reported tDCS safety and efficacy in epileptic animals or humans were included. Four review authors independently selected the studies, extracted data and assessed the methodological quality of the studies using the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions, PRISMA guidelines and Jadad Scale. A meta-analysis was not possible due to methodological, clinical and statistical heterogeneity of included studies. RESULTS:We analyzed 9 articles with different methodologies (3 animals/6 humans) with a total of 174 stimulated individuals; 109 animals and 65 humans. In vivo and in vitro animal studies showed that direct current stimulation can successfully induce suppression of epileptiform activity without neurological injury and 4/6 (67%) clinical studies showed an effective decrease in epileptic seizures and 5/6 (83%) reduction of inter-ictal epileptiform activity. All patients tolerated tDCS well. CONCLUSIONS:tDCS trials have demonstrated preliminary safety and efficacy in animals and patients with epilepsy. Further larger studies are needed to define the best stimulation protocols and long-term follow-up.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
San-Juan D,Morales-Quezada L,Orozco Garduño AJ,Alonso-Vanegas M,González-Aragón MF,Espinoza López DA,Vázquez Gregorio R,Anschel DJ,Fregni Fdoi
10.1016/j.brs.2015.01.001subject
Has Abstractpub_date
2015-05-01 00:00:00pages
455-64issue
3eissn
1935-861Xissn
1876-4754pii
S1935-861X(15)00424-6journal_volume
8pub_type
杂志文章,评审abstract:BACKGROUND:Transcutaneous spinal direct current stimulation (tsDCS) is a new non-invasive technique to modulate spinal cord activity. The pathophysiological concept of primary RLS proposes increased spinal excitability. OBJECTIVE:This pilot study used tsDCS to reduce pathologically enhanced spinal excitability in RLS ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.06.008
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) can provide insights into how differing cognitive contexts produce different brain states, through TMS-based measures of effective connectivity. For instance, in a recent study, the amplitude of the TMS-evoked response (TMS-ER)...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2013.11.004
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Vagus nerve stimulation (VNS) is indicated for treatment-resistant epilepsy and depression. Electrophysiologic recordings in the rat brain have shown that VNS promptly increases the firing rate of NE neurons and subsequently that of 5-HT neurons. Thus far, it appears that the standard stimulation parameters ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2011.04.005
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is a treatment for severe childhood-onset dystonia. A common challenge for clinicians is determining which contacts of the DBS electrode to stimulate in order to provide maximum future benefit to the patient. OBJECTIVE:To characterize how th...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.06.003
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Neuroimaging studies suggest that facial expression recognition is processed in the bilateral posterior superior temporal sulcus (pSTS). Our recent repetitive transcranial magnetic stimulation (rTMS) study demonstrates that the bilateral pSTS is causally involved in expression recognition, although involveme...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.04.011
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Low-level light therapy (LLLT) with transcranial laser is a non-invasive form of neuroenhancement shown to regulate neuronal metabolism and cognition. Attention bias modification (ABM) is a cognitive intervention designed to improve depression by decreasing negative attentional bias, but to date its efficacy...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2016.05.009
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that primary motor cortex (M1) excitability is modulated by motor skill learning and that the M1 plays a crucial role in motor memory. However, the following questions remain: (1) At what stage do changes in M1 excitability occur? (2) Are learning-induced changes in leg M1 excitab...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.07.025
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To assay peripheral inter-ictal cytokine serum levels and possible relations with non-invasive vagus nerve stimulation (nVNS) responsiveness in migraineurs. METHODS:This double-blinded, sham-controlled study enrolled 48 subjects and measured headache severity, frequency [headache days/month, number of total ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.01.008
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:A growing body of evidence suggests that deficits in GABAergic inhibitory and glutamatergic excitatory neurotransmission may be involved in the core pathophysiology of generalized anxiety disorder (GAD), a disease characterized by pathological anxious worrying. The aim of the present study was to measure mot...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2016.12.007
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) was recently shown to promote recovery of voluntary signs of consciousness in some patients in minimally conscious state (MCS). However, it remains unclear why clinical improvement is only observed in a subgroup of patients. OBJECTIVES:In this retrospective stu...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2015.07.024
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression, but only some individuals respond. Predicting response could reduce patient and clinical burden. Neural activity related to working memory (WM) has been related to mood improvements, so may represent a biomarker for...
journal_title:Brain stimulation
pub_type: 临床试验,杂志文章
doi:10.1016/j.brs.2017.10.015
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Transcranial electrical stimulation (tES) shows promise to treat neurological disorders. Knowledge of how the orthogonal components of the electric field (E-field) alter neuronal activity is required for strategic placement of transcranial electrodes. Yet, essentially no information exists on this relationsh...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.08.017
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:External trigeminal nerve stimulation (ETNS) is an emergent, non-invasive neurostimulation therapy delivered bilaterally with adhesive skin electrodes. In previous studies, ETNS was associated to a decrease in seizure frequency in patients with focal drug-resistant epilepsy (DRE). OBJECTIVE:To determine the...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.06.005
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (TMS) is a non-invasive, safe, and efficacious treatment for depression. TMS has been shown to normalize abnormal functional connectivity of cortico-cortical circuits in depression and baseline functional connectivity of these circuits predicts treatment response....
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.07.002
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Although pallidal deep brain stimulation (GPi-DBS) is an effective treatment for dystonia, it may cause important stimulation-induced side-effects such as hypokinetic dysarthria or stuttering. However, the reasons behind the occurrence of these side-effects remain unknown. OBJECTIVE:To objectively investiga...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.03.007
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Neural oscillations reflect rapidly changing brain excitability states. We have demonstrated previously with EEG-triggered transcranial magnetic stimulation (TMS) of human motor cortex that the positive vs. negative peak of the sensorimotor μ-oscillation reflect corticospinal low-vs. high-excitability states...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.09.005
更新日期:2020-01-01 00:00:00
abstract::Although rTMS is moving steadily into the mainstream as a treatment for medically refractory depression, its efficacy continues to lag behind that of more invasive neuromodulation treatments such as ECT or DBS. Here we review evidence to suggest that a fruitful, but neglected, strategy for improving rTMS efficacy may ...
journal_title:Brain stimulation
pub_type: 杂志文章,评审
doi:10.1016/j.brs.2012.08.006
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Non-invasive brain stimulation with transcranial alternating currents (tACS) has been shown to entrain slow cortical oscillations and thereby influence various aspects of visual perception. Much less is known about its potential effects on auditory perception. OBJECTIVE:In the present study, we apply a nove...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.04.004
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Recent evidence suggests that transcranial direct current stimulation (tDCS) may interact with the dopaminergic system to affect cognitive flexibility. Objective/hypotheses: We examined whether putative reduction of dopamine levels through the acute phenylalanine/tyrosine depletion (APTD) procedure and excit...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2019.08.016
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. O...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.03.012
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Non-invasive direct current stimulation (DCS) of the brain induces functional plasticity in vitro and facilitates motor learning across species. The effect of DCS on structural synaptic plasticity is currently unknown. OBJECTIVE:This study addresses the effects and the underlying mechanisms of anodal DCS on...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.07.026
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown promise as a treatment for refractory auditory hallucinations (AH) in Schizophrenia. Most previous studies have examined the effect of low frequency, left-sided stimulation (LFL) (1 Hz) to the temporoparietal cortex (TPC). Priming stimulation (6 H...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2011.12.002
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:The Perturbational Complexity Index (PCI) was recently introduced to assess the capacity of thalamocortical circuits to engage in complex patterns of causal interactions. While showing high accuracy in detecting consciousness in brain-injured patients, PCI depends on elaborate experimental setups and offline...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.05.013
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Vagus nerve stimulation (VNS) significantly reduces infarct volume in rat models of cerebral ischemia, but the mechanism of this protective effect remains open. HYPOTHESIS:This study tested the hypothesis that non-invasive VNS (nVNS), during transient middle cerebral artery occlusion (MCAO), protects the bl...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.01.034
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:In transcranial magnetic stimulation (TMS) a strong, brief current pulse driven through a coil is used for non-invasively stimulating the cortex. Properties of the electric field (E-field) induced by the pulse together with physiological parameters determine the outcome of the stimulation. In research and cl...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.01.004
更新日期:2015-05-01 00:00:00
abstract::The human motor cortex can be activated by transcranial magnetic stimulation (TMS) evoking a high-frequency repetitive discharge of corticospinal neurones. The exact physiologic mechanisms producing the corticospinal activity still remain unclear because of the complexity of the interactions between the currents induc...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2011.07.008
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Traditional transcranial magnetic stimulation mapping involves systematically delivering stimuli over a predefined grid. The pseudorandom walk method seeks to improve map acquisition times by abandoning the grid in favour of delivering stimuli randomly over a given area. OBJECTIVES:To i) determine the minim...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.07.043
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:There has been an explosion of interest in methods of exogenous brain stimulation that induce changes in the excitability of human cerebral cortex. The expectation is that these methods may promote recovery of function following brain injury. To assess their effects on motor output, it is typical to assess t...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2013.01.016
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is considered as an effective treatment for adults with major depressive disorder. However, it remains unknown whether rTMS has comparable or better efficacy in adolescents. OBJECTIVE:The current naturalistic study aimed to investigate the efficacy and cli...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.09.007
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to induce changes in cortical neural excitability. This report presents findings from the first participant of a safety and efficacy study that examined a therapeutic rTMS protocol for persons with severe traumatic brain injury (TBI)...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2008.09.004
更新日期:2009-01-01 00:00:00