Abstract：
BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown promise as a treatment for refractory auditory hallucinations (AH) in Schizophrenia. Most previous studies have examined the effect of low frequency, left-sided stimulation (LFL) (1 Hz) to the temporoparietal cortex (TPC). Priming stimulation (6 Hz) prior to LFL stimulation (hereby simply referred to as priming) has been shown to enhance the neurophysiological effects of LFL rTMS alone and, as such, may lead to greater attenuation of AH. OBJECTIVE:Therefore, this study evaluated the efficacy of priming rTMS and LFL rTMS compared to sham rTMS using MRI targeting of Heschl's gyrus (HG) within the TPC of subjects with SCZ experiencing refractory auditory hallucinations (AH). METHODS:Subjects between the ages of 18 and 65 were recruited from a tertiary care university hospital. Fifty-four subjects with medication resistant AH were randomized to receive LFL, priming, or sham rTMS for 20 treatments. The primary outcome was reduction of hallucinatory symptoms as indexed by response rates on the Psychotic Symptoms Rating Scale (PSYRATS). RESULTS:The response rates did not differ among the three treatment groups using an intention to treat analysis. The response rates did not differ in any of the secondary outcome measures. The treatment was well tolerated with minimal adverse effects including no changes in cognition during the study. CONCLUSION:These findings suggest that neither priming nor LFL rTMS of Heschl's gyrus are effective at ameliorating refractory AH in schizophrenia. ClinicalTrials.gov Identifier: NCT01386918.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Blumberger DM,Christensen BK,Zipursky RB,Moller B,Chen R,Fitzgerald PB,Daskalakis ZJdoi
10.1016/j.brs.2011.12.002subject
Has Abstractpub_date
2012-10-01 00:00:00pages
577-85issue
4eissn
1935-861Xissn
1876-4754pii
S1935-861X(11)00171-9journal_volume
5pub_type
杂志文章,随机对照试验abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has been proposed for stabilizing the antidepressant effect of sleep deprivation (SD) by preventing the relapse after a night of recovery sleep. In this study, we aimed to replicate these data coming from a small pilot study in a larger patient sample. MET...
journal_title：Brain stimulation
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abstract：BACKGROUND:Deep brain stimulation of the ventro-intermedius nucleus of the thalamus is an established treatment for tremor of differing etiologies but factors that may predict the short- and especially long-term outcome of surgery are still largely unknown. METHODS:We retrospectively investigated the clinical, pharmac...
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更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
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pub_type： 杂志文章
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abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) was recently shown to promote recovery of voluntary signs of consciousness in some patients in minimally conscious state (MCS). However, it remains unclear why clinical improvement is only observed in a subgroup of patients. OBJECTIVES:In this retrospective stu...
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brs.2015.07.024
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abstract：CONTEXT:The aim of this study was to assess whether the combination of low frequency repetitive transcranial magnetic stimulation (rTMS) and venlafaxine (150-225 mg/day) is effective and safe for treatment-resistant unipolar depression (TRD). METHOD:In a multicenter (18 centers) randomized double blind controlled tria...
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2014-11-01 00:00:00
abstract：:The intensity of sound emanating from the discharge of magnetic coils used in repetitive transcranial magnetic stimulation (rTMS) can potentially cause acoustic trauma. Per Occupational Safety and Health Administration (OSHA) standards for safety of noise exposure, hearing protection is recommended beyond restricted l...
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abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (TMS) is a non-invasive, safe, and efficacious treatment for depression. TMS has been shown to normalize abnormal functional connectivity of cortico-cortical circuits in depression and baseline functional connectivity of these circuits predicts treatment response....
journal_title：Brain stimulation
pub_type： 杂志文章
doi：10.1016/j.brs.2017.07.002
更新日期：2017-01-01 00:00:00
