Abstract:
BACKGROUND:Recent evidence suggests that transcranial direct current stimulation (tDCS) may interact with the dopaminergic system to affect cognitive flexibility. Objective/hypotheses: We examined whether putative reduction of dopamine levels through the acute phenylalanine/tyrosine depletion (APTD) procedure and excitatory anodal tDCS of the dorsolateral prefrontal cortex (dlPFC) are causally related to cognitive flexibility as measured by task switching and reversal learning. METHOD:A double-blind, sham-controlled, randomised trial was conducted to test the effects of combining anodal tDCS and depletion of catecholaminergic precursor tyrosine on cognitive flexibility. RESULTS:Anodal tDCS and tyrosine depletion had a significant effect on task switching, but not reversal learning. Whilst perseverative errors were significantly improved by anodal tDCS, the APTD impaired reaction times. Importantly, the combination of APTD and anodal tDCS resulted in cognitive performance which did not statistically differ to that of the control condition. CONCLUSIONS:Our results suggest that the effects of tDCS on cognitive flexibility are modulated by dopaminergic tone.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Borwick C,Lal R,Lim LW,Stagg CJ,Aquili Ldoi
10.1016/j.brs.2019.08.016subject
Has Abstractpub_date
2020-01-01 00:00:00pages
105-108issue
1eissn
1935-861Xissn
1876-4754pii
S1935-861X(19)30362-6journal_volume
13pub_type
杂志文章,随机对照试验abstract:BACKGROUND:The final common pathway in tinnitus generation is considered to be synchronized auditory oscillatory hyperactivity. Intracranial auditory cortex stimulation (iACS) via implanted electrodes has been developed to treat severe cases of intractable tinnitus targeting this final common pathway, in the hope of be...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.04.004
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Recently, navigated transcranial magnetic stimulation (nTMS) has been suggested to be useful in preoperative functional localization of motor cortex in patients having tumors close to the somatomotor cortex. Resection of tumors in anatomically predicted eloquent areas without adverse effects have emphasized ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.04.012
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS), a neuromodulatory non-invasive brain stimulation technique, has shown promising results in basic and clinical studies. The known interindividual variability of the effects, however, limits the efficacy of the technique. Recently we reported neurophysiological e...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2021.01.016
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:Theta burst stimulation (TBS) is a pattern of repetitive transcranial magnetic stimulation that has been demonstrated to facilitate or suppress human corticospinal excitability when applied intermittently (iTBS) or continuously (cTBS), respectively. While the fundamental pattern of TBS, consisting of bursts ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2013.12.007
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Studies have found that pairing vagus nerve stimulation (VNS) with motor activity accelerates cortical reorganization. This synchronous pairing may enhance motor recovery. OBJECTIVE:To develop and validate a motor-activated auricular vagus nerve stimulation (MAAVNS) system as a potential neurorehabilitation...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.02.028
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:In a seminal paper, Galea et al. (Modulation of cerebellar excitability by polarity-specific noninvasive direct current stimulation. 2009. J Neurosci 29, 9115-9122) showed that cerebellar transcranial direct current stimulation (ctDCS) alters cerebellar-M1 connectivity. This effect has been explained by ctDC...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.04.002
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Temporal lobe epilepsy (TLE) is often associated with memory deficits. Given the putative role for sleep spindles memory consolidation, spindle generators skewed toward the affected lobe in TLE subjects may be a neurophysiological marker of defective memory. Slow-oscillatory transcranial direct current stimu...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2015.01.410
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:External trigeminal nerve stimulation (ETNS) is an emergent, non-invasive neurostimulation therapy delivered bilaterally with adhesive skin electrodes. In previous studies, ETNS was associated to a decrease in seizure frequency in patients with focal drug-resistant epilepsy (DRE). OBJECTIVE:To determine the...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.06.005
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is a treatment for severe childhood-onset dystonia. A common challenge for clinicians is determining which contacts of the DBS electrode to stimulate in order to provide maximum future benefit to the patient. OBJECTIVE:To characterize how th...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.06.003
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is able to modify cortical excitability and activity in humans. OBJECTIVE:The aim of the present study was to analyze the effects of tDCS of the primary sensory cortex (SI) on thermal and mechanical perception, assessed by quantitative sensory testing (QST). M...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2010.12.002
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) for the experimental treatment of tinnitus or auditory hallucinations aims at a modulation of cortical activity in areas of auditory perception and processing. Continuous theta burst stimulation (cTBS) is a patterned rTMS paradigm with lower stimulation int...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2012.10.005
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Transcranial magnetic stimulation (TMS) is a noninvasive neuromodulation technique with therapeutic applications for the treatment of major depressive disorder (MDD). The standard protocol uses high frequency stimulation over the left dorsolateral prefrontal cortex (DLPFC) identified in a heuristic manner le...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.10.004
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The ability to exert self-control over temptation is a fundamental component of smoking behavior change. Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) has been shown to modulate cognitive control circuits. Although prior studies show that stimulation reduces cig...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2015.10.004
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Although a significant subset of patients with major depressive disorder (MDD) fail to respond to medical or behavioural therapy, deep brain stimulation (DBS) applied to the subgenual cingulate cortex (SCC; sg25) has been shown to reduce depressive symptoms in a subset of patients. This area receives project...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2016.11.013
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:A session of motor skill learning is accompanied by transient increases in corticospinal excitability(CSE), which are thought to reflect acute changes in neuronal connectivity associated with improvements in sensorimotor performance. Factors influencing changes in excitability and motor skill with continued ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.11.005
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) has been used for neuropsychiatric disorders in clinical and research settings for almost 50 years now. Recent evidence demonstrates some efficacy in treating obsessive-compulsive disorder and major depression in patients refractory to other treatment modalities beyond single cas...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2010.03.002
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Transcutaneous vagus nerve stimulation (tVNS) is a new, non-invasive technique being investigated as an intervention for a variety of clinical disorders, including epilepsy and depression. It is thought to exert its therapeutic effect by increasing central norepinephrine (NE) activity, but the evidence suppo...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.12.224
更新日期:2019-01-01 00:00:00
abstract::Right unilateral ultra-brief electroconvulsive therapy (RUL UB ECT) has been shown to be efficacious with minimal cognitive adverse effects in adult patients with major depression. We present the case of a 14-year-old girl with major depressive disorder with catatonic and psychotic features whose symptoms remitted aft...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2009.07.003
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Accurate data on the sound emitted by transcranial magnetic stimulation (TMS) coils is lacking. METHODS:We recorded the sound waveforms of seven coils with high bandwidth. We estimated the neural stimulation strength by measuring the induced electric field and applying a strength-duration model to account f...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.03.004
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Vagus Nerve Stimulation (VNS) has seizure-suppressing effects but the underlying mechanism is not fully understood. To further elucidate the mechanisms underlying VNS-induced seizure suppression at a neurophysiological level, the present study examined effects of VNS on hippocampal excitability using dentate...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.09.009
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:A prime objective driving the recent development of human neural prosthetics is to stimulate neural circuits in a manner time-locked to ongoing brain activity. The human supplementary motor area (SMA) is a particularly useful target for this objective because it displays characteristic neural activity just p...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.03.003
更新日期:2018-01-01 00:00:00
abstract::Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the surgical therapy of choice for medically intractable Parkinson's disease. However, quantitative understanding of the interaction between the electric field generated by DBS and the underlying neural tissue is limited. Recently, computational ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2010.01.003
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Conventional rTMS protocols for major depression commonly employ stimulation sessions lasting >30 min. However, recent studies have sought to improve costs, capacities, and outcomes by employing briefer protocols such as theta burst stimulation (iTBS). OBJECTIVE:To compare safety, effectiveness, and outcome...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.11.002
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:There has been an explosion of interest in methods of exogenous brain stimulation that induce changes in the excitability of human cerebral cortex. The expectation is that these methods may promote recovery of function following brain injury. To assess their effects on motor output, it is typical to assess t...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2013.01.016
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Directional Deep Brain Stimulation (D-DBS) allows axially asymmetric electrical field shaping, away from structures causing side-effects. However, concerns regarding the impact on device lifespan and complexity of the monopolar survey have contributed to sparing use of these features. OBJECTIVE:To investiga...
journal_title:Brain stimulation
pub_type: 临床试验,杂志文章
doi:10.1016/j.brs.2017.12.015
更新日期:2018-01-01 00:00:00
abstract::The intensity of sound emanating from the discharge of magnetic coils used in repetitive transcranial magnetic stimulation (rTMS) can potentially cause acoustic trauma. Per Occupational Safety and Health Administration (OSHA) standards for safety of noise exposure, hearing protection is recommended beyond restricted l...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.01.056
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Cognitive dysfunction is commonly observed in diabetic patients. We have previously reported that anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex can facilitate visuospatial working memory in diabetic patients with concomitant diabetic peripheral neuropathy and m...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.08.007
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Understanding actions based on either language or observation of gestures is presumed to involve the motor system, and reflect the engagement of an embodied conceptual network. The role of the left inferior frontal gyrus (IFG) in language tasks is well established, but the role of the right hemisphere is unc...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.12.001
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Current density is considered an important factor in determining the outcomes of tDCS, and is determined by the current intensity and electrode size. Previous studies examining the effect of these parameters on motor cortical excitability with small sample sizes reported mixed results. OBJECTIVE/HYPOTHESIS:...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.08.003
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Dual-site transcranial magnetic stimulation (ds-TMS) is a neurophysiological technique to measure functional connectivity between cortical areas. OBJECTIVE/HYPOTHESIS:To date, no study has used ds-TMS to investigate short intra-hemispheric interactions between the somatosensory areas and primary motor corte...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.04.009
更新日期:2019-01-01 00:00:00