Abstract:
BACKGROUND:Although one of the most frequent diagnosed mental illnesses worldwide, it appears to be challenging to successfully treat major depressive disorder (MDD). Although the phenomenon of treatment-resistant depression (TRD) still remains unclear, the subgenual anterior cingulate cortex (sgACC) has been put forward as a possible neurobiological marker to evaluate clinical effects of a variety of antidepressant treatments, including repetitive transcranial magnetic stimulation (rTMS). Accelerated high-frequency (HF)-rTMS may have the potential to rapidly result in beneficial clinical outcomes in TRD. No studies yet examined the clinical effects of such accelerated stimulation treatment paradigms on sgACC regional glucose metabolism (CMRglc), nor the predictive value of the latter for clinical outcome. OBJECTIVE:First, we investigated the predictive value of baseline sgACC metabolic activity for clinical outcome. Second, we hypothesized that in clinical responders only accelerated HF-rTMS treatment would result in significant metabolic decreases. METHODS:We recruited right-handed antidepressant-free unipolar melancholic TRD patients to participate in a two-week randomized sham-controlled crossover HF-rTMS treatment study. Stimulation was applied to the left dorsolateral prefrontal cortex (DLPFC). Fifteen patients underwent 18FDG PET (CMRglc) at baseline (T0), after the first week (T1) of accelerated HF-rTMS and at the end of the treatment after the second week (T2). RESULTS:Higher baseline sgACC metabolic activity may indicate beneficial clinical outcome to this kind of accelerated HF-rTMS treatment. Moreover, clinical response resulted in a significant decrease in sgACC CMRglc. Non-response did not affect sgACC CMRglc. CONCLUSIONS:Our results add to the sgACC as a specific neurobiological marker for anti-depressive response in accelerated HF-rTMS treatment paradigms. Such protocols may not only have the ability to result in fast clinical responses but they may also have potential to acutely modulate a dysfunctional sgACC.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Baeken C,Marinazzo D,Everaert H,Wu GR,Van Hove C,Audenaert K,Goethals I,De Vos F,Peremans K,De Raedt Rdoi
10.1016/j.brs.2015.01.415subject
Has Abstractpub_date
2015-07-01 00:00:00pages
808-15issue
4eissn
1935-861Xissn
1876-4754pii
S1935-861X(15)00879-7journal_volume
8pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Conventional rTMS protocols for major depression commonly employ stimulation sessions lasting >30 min. However, recent studies have sought to improve costs, capacities, and outcomes by employing briefer protocols such as theta burst stimulation (iTBS). OBJECTIVE:To compare safety, effectiveness, and outcome...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.11.002
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The use of repetitive transcranial magnetic stimulation (rTMS) as both therapeutic and experimental tools has grown enormously over the past decade. However, variability in response to rTMS is one challenge that remains to be solved. Estrogen can impact neural plasticity and may also affect plastic changes f...
journal_title:Brain stimulation
pub_type: 临床试验,杂志文章
doi:10.1016/j.brs.2019.05.007
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Vagus nerve stimulation (VNS) paired with forelimb training drives robust, specific reorganization of movement representations in the motor cortex. The mechanisms that underlie VNS-dependent enhancement of map plasticity are largely unknown. The cholinergic nucleus basalis (NB) is a critical substrate in cor...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.12.007
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Theta burst stimulation (TBS) is a pattern of repetitive transcranial magnetic stimulation that has been demonstrated to facilitate or suppress human corticospinal excitability when applied intermittently (iTBS) or continuously (cTBS), respectively. While the fundamental pattern of TBS, consisting of bursts ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2013.12.007
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Vagus nerve stimulation (VNS) is indicated for treatment-resistant epilepsy and depression. Electrophysiologic recordings in the rat brain have shown that VNS promptly increases the firing rate of NE neurons and subsequently that of 5-HT neurons. Thus far, it appears that the standard stimulation parameters ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2011.04.005
更新日期:2012-07-01 00:00:00
abstract:CONTEXT:The aim of this study was to assess whether the combination of low frequency repetitive transcranial magnetic stimulation (rTMS) and venlafaxine (150-225 mg/day) is effective and safe for treatment-resistant unipolar depression (TRD). METHOD:In a multicenter (18 centers) randomized double blind controlled tria...
journal_title:Brain stimulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.brs.2014.07.040
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Recently, navigated transcranial magnetic stimulation (nTMS) has been suggested to be useful in preoperative functional localization of motor cortex in patients having tumors close to the somatomotor cortex. Resection of tumors in anatomically predicted eloquent areas without adverse effects have emphasized ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.04.012
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Studies have found that pairing vagus nerve stimulation (VNS) with motor activity accelerates cortical reorganization. This synchronous pairing may enhance motor recovery. OBJECTIVE:To develop and validate a motor-activated auricular vagus nerve stimulation (MAAVNS) system as a potential neurorehabilitation...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.02.028
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Directional Deep Brain Stimulation (D-DBS) allows axially asymmetric electrical field shaping, away from structures causing side-effects. However, concerns regarding the impact on device lifespan and complexity of the monopolar survey have contributed to sparing use of these features. OBJECTIVE:To investiga...
journal_title:Brain stimulation
pub_type: 临床试验,杂志文章
doi:10.1016/j.brs.2017.12.015
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Electroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and future antidepressant research. OBJECTIVE:To determine whether clinical response to ECT is related t...
journal_title:Brain stimulation
pub_type: 杂志文章,多中心研究
doi:10.1016/j.brs.2020.02.020
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is considered as an effective treatment for adults with major depressive disorder. However, it remains unknown whether rTMS has comparable or better efficacy in adolescents. OBJECTIVE:The current naturalistic study aimed to investigate the efficacy and cli...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.09.007
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS), a neuromodulatory non-invasive brain stimulation technique, has shown promising results in basic and clinical studies. The known interindividual variability of the effects, however, limits the efficacy of the technique. Recently we reported neurophysiological e...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2021.01.016
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulatory technique that has broad diagnostic and therapeutic potential across a range of neurological and psychiatric diseases. OBJECTIVE:This study utilises a bibliometric approach to systematically and comprehensively evaluate the literature...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.01.002
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Vagus Nerve Stimulation (VNS) has seizure-suppressing effects but the underlying mechanism is not fully understood. To further elucidate the mechanisms underlying VNS-induced seizure suppression at a neurophysiological level, the present study examined effects of VNS on hippocampal excitability using dentate...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.09.009
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Although some studies have reported significant reductions in food cravings following the single-session of repetitive transcranial magnetic stimulation (rTMS), there is little research on the effects of multi-session of rTMS on food consumption and body weight in obese subjects. OBJECTIVE:We conducted 4-we...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2019.07.020
更新日期:2019-01-01 00:00:00
abstract::The intensity of sound emanating from the discharge of magnetic coils used in repetitive transcranial magnetic stimulation (rTMS) can potentially cause acoustic trauma. Per Occupational Safety and Health Administration (OSHA) standards for safety of noise exposure, hearing protection is recommended beyond restricted l...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.01.056
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Neural oscillations reflect rapidly changing brain excitability states. We have demonstrated previously with EEG-triggered transcranial magnetic stimulation (TMS) of human motor cortex that the positive vs. negative peak of the sensorimotor μ-oscillation reflect corticospinal low-vs. high-excitability states...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.09.005
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:No consensus exists in the clinical transcranial magnetic stimulation (TMS) field as to the best method for targeting the left dorsolateral prefrontal cortex (DLPFC) for depression treatment. Two common targeting methods are the Beam F3 method and the 5.5 cm rule. OBJECTIVE:Evaluate the anatomical reliabili...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.01.010
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The left dorsal premotor cortex (PMd) plays an important role in movement selection and is abnormally activated in imaging studies in patients with right-sided focal hand dystonia (FHD). OBJECTIVE:The aims of this study were to assess the role of left PMd in patients with FHD and in the genesis of surround ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2009.03.004
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:In transcranial magnetic stimulation (TMS) a strong, brief current pulse driven through a coil is used for non-invasively stimulating the cortex. Properties of the electric field (E-field) induced by the pulse together with physiological parameters determine the outcome of the stimulation. In research and cl...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.01.004
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has been proposed for stabilizing the antidepressant effect of sleep deprivation (SD) by preventing the relapse after a night of recovery sleep. In this study, we aimed to replicate these data coming from a small pilot study in a larger patient sample. MET...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2011.02.005
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) has emerged as a potential therapeutic strategy in the treatment of neurological disorders including epilepsy. However, the cellular mechanism responsible for the effects of DBS remains largely undefined. Therefore, using electrophysiological approach, we aimed to determine the a...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.11.001
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Non-invasive direct current stimulation (DCS) of the brain induces functional plasticity in vitro and facilitates motor learning across species. The effect of DCS on structural synaptic plasticity is currently unknown. OBJECTIVE:This study addresses the effects and the underlying mechanisms of anodal DCS on...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2019.07.026
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Balance problems contribute to reduced quality of life in Parkinson's disease (PD) and available treatments are often insufficient for treating axial and postural motor symptoms. OBJECTIVE:To investigate the safety of use and possible effects of stochastic vestibular stimulation (SVS) alone and combined wit...
journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2014.11.019
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Theories of executive control propose that communication between medial frontal cortex (MFC) and lateral prefrontal cortex (lPFC) is critical for learning. 6-Hz phase synchronization may be the mechanism by which neural activity between MFC and lPFC is coordinated into a functional network. Recent evidence s...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.02.008
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) has been used to improve exercise performance, though the protocols used, and results found are mixed. OBJECTIVE:We aimed to analyze the effect of tDCS on improving exercise performance. METHODS:A systematic search was performed on the following databases, unt...
journal_title:Brain stimulation
pub_type: 杂志文章,meta分析
doi:10.1016/j.brs.2018.12.227
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. O...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.03.012
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Transcutaneous spinal direct current stimulation (tsDCS) is a new non-invasive technique to modulate spinal cord activity. The pathophysiological concept of primary RLS proposes increased spinal excitability. OBJECTIVE:This pilot study used tsDCS to reduce pathologically enhanced spinal excitability in RLS ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.06.008
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Pairing sensory or motor events with vagus nerve stimulation (VNS) can reorganize sensory or motor cortex. Repeatedly pairing a tone with a brief period of VNS increases the proportion of primary auditory cortex (A1) responding to the frequency of the paired tone. However, the relationship between VNS intens...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.08.018
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:A growing body of evidence suggests that deficits in GABAergic inhibitory and glutamatergic excitatory neurotransmission may be involved in the core pathophysiology of generalized anxiety disorder (GAD), a disease characterized by pathological anxious worrying. The aim of the present study was to measure mot...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2016.12.007
更新日期:2017-01-01 00:00:00